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Ukr Biokhim Zh (1978) ; 64(2): 94-8, 1992.
Artigo em Russo | MEDLINE | ID: mdl-1413125

RESUMO

Three reactions (nucleophile substitution, thiolysis and N-deoxygenation) catalyzed by rat liver glutathione transferase have been studied using several N-heterylazimine inhibitors. The inhibitors are sharply different in their effectiveness in the transferase reactions. Their efficiency depends on their structure. The mechanism which underlies the found regularities is suggested.


Assuntos
Glutationa Transferase/antagonistas & inibidores , Fígado/enzimologia , Animais , Catálise , Estrutura Molecular , Oxigênio/metabolismo , Ratos , Ratos Wistar , Compostos de Sulfidrila/metabolismo
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