Recurrent venous thrombosis related to overweight and obesity: results from the MEGA follow-up study.

Essentials Whether excess body weight influences recurrent venous thrombosis (VT) risk is uncertain. We included 3889 VT patients, classified into body mass index (BMI) strata to estimate recurrent VT risk. No evidence of an increased risk for excess body weight was found. Measuring BMI is not a good tool to identify patients at high risk of VT recurrence. SUMMARY: Background Studies on the risk of recurrent venous thrombosis in patients with excess body weight have yielded conflicting results. Objective To estimate whether excess body weight increases the risk of recurrent venous thrombosis. Patients/Methods We included 3889 patients, followed after a first venous thrombosis for a median of 5.6 years. Body mass index (BMI) was calculated as weight in kilograms/height in meters squared, and classified according to three a priori-defined categories (normal weight, overweight, and obesity), as well as by percentiles. Crude incidence rates with 95% confidence intervals (CIs) of recurrent venous thrombosis were estimated as the number of events over the accumulated follow-up time in each BMI category. Cox regression models were used to compare groups, adjusted for age and sex. Results The incidence rate of recurrent venous thrombosis was 3.3 per 100 patient-years. Adjusted hazard ratios of recurrent venous thrombosis in overweight or obese patients in comparison with patients with normal weight were 1.05 (95% CI 0.88-1.27) and 0.94 (95% CI 0.74-1.19), respectively. Stratification by BMI percentile categories yielded similar results. The association between BMI and recurrent venous thrombosis was also absent after stratification by sex, (although a small effect for overweight, but not for obese women, was found), or into those with a first provoked or unprovoked event, or deep vein thrombosis and pulmonary embolism. Conclusions We found no evidence of an association between excess body weight and recurrent venous thrombosis. Measuring BMI is not a useful tool to identify patients at high risk of recurrence.

Field experience on indoor radon, thoron and their progenies with solid-state detectors in a survey of Kosovo and Metohija (Balkan region).

Since 1996/97, indoor radon has been measured in scattered locations around Kosovo. In the most recent campaign, apart from radon, thoron and Rn and Tn progenies have also been measured. The current survey involves 48 houses, in which different detectors have been deployed side-by-side in one room, in order to measure indoor radon and thoron gas with RADUET devices based on CR-39 detectors (analysed by Japanese collaborators) and with direct thoron and radon progeny sensor (DTPS and DRPS) devices based on LR-115 detectors (analysed by collaborators from India). Estimated arithmetic mean values of concentrations in 48 houses are 122 Bq m(-3) for radon and 136 Bq m(-3) for thoron. Those for equilibrium equivalent radon concentration and equilibrium equivalent thoron concentration based on measurements in 48 houses are 40 and 2.1 Bq m(-3), respectively. The arithmetic mean value of the equilibrium factor is estimated to be 0.50 ± 0.23 for radon and 0.037 ± 0.041 for thoron. The preliminary results of these measurements are reported, particularly regarding DTPS and DRPS being set up in real field conditions for the first time in the Balkan region. The results are to be understood under the caveat of open questions related to measurement protocols which yield reproducible and representative results, and to quality assurance of Tn and Rn/Tn progeny measurements in general, some of which are discussed.

[Prevention of early postoperative hematoma with the use of elastic bandages. Its ultrasonic diagnosis and control]. / Prevencija ranih poslijeoperacijskih hematoma primjenom elasticnog zavoja. Njihova ultrazvucna dijagnostika i kontrola.

The authors stress out the importance of an application of elastic bandage for a prevention of the early postoperative hemathomas in traumatized patients, whose effect can be controlled by ultrasound. 58 patients were elaborated, of whom in 30 cases an elastic bandage was placed at the end of surgery, and 28 patients (control group) without dressing. In 8 patients of the control group, an existence of postoperative hemathomas was proved by ultrasound, while only in two cases with postoperative bandage a presence of such hemathoma could be discovered. Lesser number of postoperative hemathomas in patients with elastic bandage is statistically important (p less than 0.001). Obtained results indisputably point out the value of elastic bandage application in the course of first three postoperative days in traumatized patients.

[Factors influencing physiologic pressure variations of the lower esophageal sphincter in healthy probands]. / Untersuchung von Faktoren mit Einfluss auf physiologische Druckschwankungen des unteren Osophagussphinkters in gesunden Probanden.

Manometric characteristics of lower esophageal sphincter (LES) in 59 healthy persons have been investigated. The aim of the investigation was to find out possible physiological changes of LES pressures considering posture, part of the day, maximal inspiration and expiration, empty or partially full stomach and abdominal compression. It has been proved that the minimal value of lower esophageal sphincter pressure in all the investigated patients was 1.77 kPA (13.3 mm Hg) while the maximal one was 4.53 kPa (34.0 mm Hg). The absolute difference between the lowest and the highest measured lower esophageal sphincter pressure was 1.43 kPa (10.77 mm Hg). The mean value of all pressures was 2.99 kPa (22.4 mm Hg). It seems that the posture during pressure measuring is irrelevant. The pressure does not vary more significantly considering neither the time of the day nor any exertion of the examinee.