[Tumor necrosis factor in medicinal interferon preparations]. / Faktor nekroza opukholi v meditsinskikh preparatakh interferona.

In response to virus induction a culture of donor leukocytes alongside with interferon (IF-alpha) produced a factor of tumor necrosis (TNF). The kinetics of TNF and IF-alpha biosynthesis did not depend on the kind of IF used for priming, was rapid, with maximum production within 7-8 hours. Antibodies to IF-alpha and IF-alpha had no effect on TNF production, while antibody to TNF did not reduce IF-alpha yields. TNF in detectable titres was present in medical preparations of native IF-alpha but was absent in preparations of recombinant IF-alpha and IF-alpha as well as in an injection preparation of IF purified by chemical methods.

[Kaposi's sarcoma in a female patient taking corticosteroids for a long time]. / Sarkoma Kaposhi u dlitel'no prinimavshei kortikosteroidy bol'noi.

A 65-year-old female patient has been orally taking corticosteroids (8 pills of prednisolone) for a severe form of bronchial asthma. In 1979 Kaposi's sarcoma was diagnosed for the first time; the diagnosis has been histologically confirmed. Several times the patient has been effectively treated with prospidin. The disease course got worse from 1984 on: the eruptions disseminated and the condition recurred every 2-3 months. This case is remarkable because Kaposi's sarcoma has developed in a patient treated with corticosteroids for asthma for a long time.

[Terminology, clinical picture and treatment of atopic dermatitis and neurodermatitis]. / K voprosu o terminologii, klinike i lechenii atopicheskogo dermatita i neirodermita.

Analysis of 66 cases with neurodermatitis has made it possible to distinguish five conditions: atopic dermatitis, diffuse, disseminated, or local neurodermatitis, prurigo. Each of these nosologic entities in characterized by a specific course. The authors consider that the term 'atopic dermatitis' is inadequate and should be changed.