[Morbidity from hemoblastosis in the Rovenskii district of Ukraine before and after the accident at the Chernobyl Nuclear Power Station]. / Zabolevaemost' gemoblastozami v Rovenskoi oblasti Ukrainy do i posle avarii na Chernobyl'skoi AES.

Hemoblastosis morbidity in children and adult populations and its structure were studied during the period of 1981-1992 at Rovensky district of Ukraine, 6 northern districts of which were affected by radionuclides after Chernobyl AES accident. Primary documentation, actual and archival records were the object of study: registration diaries, records and ambulatory cards. Expeditional method of investigation. During the last 11 years a rise of hemoblastosise morbidity was stated in Rovensky district, especially after the accident, and it was confirmed by a profound statistical analysis of data on leukemia morbidity before and after the accident. Among different nosological forms after the accident the rate of leukemia morbidity as well as myeloma disease and malignant lymphoma morbidity, rose markedly. No significant difference was marked in hemoblastoses (excluding acute leukemia) in non-contaminated and contaminated with radionuclides regions of the district, and in contaminated zones depending on effective equivalent doze. Acute leukemia morbidity in contaminated regions after the accident was statistically reliably higher.

[Circulating immune complexes and the immune system in hemorrhagic vasculitis]. / Tsirkuliruiushchie immunnye kompleksy i immunnaia sistema pri gemorragicheskom vaskulite.

The paper is concerned with the results of studying the concentration of circulating immune complexes and immune system (the number of lymphocyte populations and subpopulations in the peripheral blood, the level of serum immunoglobulins) in 45 patients aged 10 to 72 years with hemorrhagic vasculitis depending on the disease pattern and course before and after the treatment. The patients suffering from hemorrhagic vasculitis manifested appreciable changes in humoral immunity and negligible derangement of cellular immunity associated with dramatic enhancement of complex formation. The intensity of the alterations was discovered to be dependent on the pattern and course of the disease.

[Immune disorders in hemophiliac patients]. / Immunnye narusheniia u bol'nykh gemofiliei.

Hemophiliac patients develop disorders of the immune status as a result of transfusion therapy: a decrease in the number of T-lymphocytes and the ratio T-helpers/T-suppressors resulting from a decrease in the number of T-helpers, enhancement of immunoglobulinogenesis, and an increase in the level of circulating immune complexes. A degree of the above changes depends on a dose and period of the use of antihemophilic drugs. Hemophiliac patients require immunological monitoring, clinical substantiation of doses and a prolonged period of administration of blood preparations.

[Indices of cellular and humoral immunity in chronic myeloproliferative diseases]. / Pokazateli kletochnogo i gumoral'nogo immuniteta pri khronicheskikh mieloproliferativnykh zabolevaniiakh.

The populations of lymphocytes and serum immunoglobulins were explored in 20 patients with erythremia, 26 patients with sub-leukemic myelosis, 38 patients with pronounced chronic myeloid leukemia, and 33 patients with the blastic phase of the illness. The patients with chronic myeloproliferative diseases manifested cellular immunodeficiency that was aggravated as the disease progressed. In the pronounced stage, the patients showed relative preservation of humoral immunity whereas in the terminal stage they developed humoral deficiency. Study of the time-course of changes in the immunological characteristics has demonstrated that deterioration of the characteristics starts during blast transformation of myeloproliferative diseases. This may serve as a criterion for predicting exacerbations and early diagnosis of the blastic phase.

[Immune complexes in neoplastic diseases and autoimmune processes]. / Immunnye kompleksy pri opukholevykh zabolevaniiakh i autoimmunnykh protsessakh.

The level and possible pathologic relevance of circulating immune complexes (ICs) were investigated by polyethylene glycol precipitation method in sera of 109 untreated cancer patients (melanoblastoma, lung and breast cancer) and 118 patients with various immune complex diseases (collagenosis, nephropathia, vasculitis and immune hemocytopenia). The highest level of ICs was established in all patients with melanoblastoma. The raised concentration of ICs was registered in patients with malignancies of lung and breast (42 and 44%, respectively). A relationship between increased level of ICs and the rate of its growth in breast cancer patients, on the one hand, and clinical stage of the disease, on the other, was shown. The pathogenic effects of ICs in malignancies and immune complex diseases are compared.