[Prophylaxis of purulent complications in operations on large joints by endolymphatic infusion of drugs]. / Profilaktika gnoinykh osloznenii pri operatsiiakh na krupnykh sustavakh s pomoshch'iu éndolimfaticheskogo vvedeniia lekarstvennykh veshchestv.

2 groups of patients operated on knee joints for traumatic injuries were examined. In the study group endolymphatic drug therapy was carried out in postoperative period, in control group of patients conventional way of intramuscular administration of preparations was used. During the treatment, plasmatic cells, macrophages and tissue basophiles in synovial liquor were studied as well as synthesis of nucleic acids (DNA and RNA) in plasmatic cells. It was shown that immune homeostasis of synovial liquor in postoperative period normalized faster in endolymphatic administration. The studies of tissue basophiles have shown that inflammatory process in the knee joint is completed faster when endolymphatic route of drug administration was used. Clinical results evidence of higher effectiveness of endolymphatic therapy in comparison with conventional method of treatment in postoperative period. In the former case the inflammatory process was completed by the 5th day, in the latter--by the 7th-9th day. The endolymphatic therapy in all the patients resulted in healing of operation wounds by primary intention. In the group of patients treated by standard methods, suppuration of the wound was detected in 6 from 27 patients and postoperative synovitis in 7-9 days was observed in 6 patients.

[The cardiac microcirculatory bed based on data from the scanning electron microscopy of corrosion preparations]. / Mikrotsirkuliatornoe ruslo serdtsa po dannym skaniruiushchei élektronnoi mikroskopii korrozionnykh preparatov.

The method of scanning electron microscopy of cast preparations was used to study the volumetric interrelations of hemo- and lymph microcirculation bed links as well as specific features of the relief of the wall of the heart vessels in question. The lymphangions were confirmed to be rightfully considered as a morphological unit of the lymph microcirculation bed. The valve-shaped impressions and folds of the relief of a cast of lymph capillaries and postcapillaries were found which shows the ability of the lymph postcapillaries to maintain a one-direction flow of lymph and to change the lumen width for different amounts of the flowing lymph.

[The lymphatic system of the lower extremities in patients with obliterating diseases of the terminal portion of the aorta and its branches]. / Limfaticheskaia sistema nizhnikh konechnostei u bol'nykh s obliteriruiushchimi zabolevaniiami terminal'nogo otdela aorty i ee vetvei.

The paper deals with the results of X-ray lymphographic and morphological studies of the peripheral lymphatic system in 82 patients with various stages of chronic lower extremity arterial insufficiency. Destructive and sclerotic changes in lymphatic vessels, inguinal lymph nodes, and impairments in lymph flow whose severity was in proportion to the stage of chronic ischemia were detected. The associated immune, barrier-filtration and transport dysfunctions called for their adequate correction. In patients with Stages II and III ischemia, direct controlled endolymphatic therapy promotes the improvement of tissue lymphatic drainage and hemocirculation in the diseased extremity and recovery of immune homeostasis in the region.

[Primary controlled endolymphatic antibiotic therapy in traumatology and orthopedics]. / Priamaia upravlennaia éndolimfaticheskaia antibiotikoterapiia v travmatologii i ortopedii.

The work analyses 55 cases of traumatic osteomyelitis of the leg bones, open fractures of the leg bones, and medial fractures of the femoral neck. Patients with medial fractures of the neck of the femur were treated by endoprosthesis after Mur-Kaplan. Endolymphatic antibiotic therapy was included in the complex of therapeutic measures in each group of patients. This method allowed suppuration of the postoperative wounds to be avoided and promoted in this manner rehabilitation of the patients.

[Main trends in the development of modern lymphology]. / Osnovnye napravleniia razvitiia sovremennoi limfologii.

At a historical approach in studying the lymphatic system the role of the method for investigation of this important drainage system of the organism is noted. Certain modern morphological methods of investigation are presented. Their high degree of informativeness+ and perspectives of their application for widening the notion of lymphology as a science are shown. Problems necessary to be solved in connection with a successful adoption into clinical practice of operative methods of lymphocorrection are determined. Concrete tasks for investigating morphology, function and pathology of lymph nodes and lymph transport are proposed.

[The lymphatic bed of the liver in man and animal and its transformation in disordered bile outflow]. / Limfaticheskoe ruslo pecheni cheloveka i zhivotnykh i ego preobrazovaniia pri narushenii ottoka zhelchi.

The lymphatic bed has been studied in 141 hepatic preparations of the man, dog and white rat. Development of obturation in the common bile duct in the man and at modelling a similar process in the animals results in essential morphological adaptive-compensatory and destructive changes in the hepatic lymphatic bed. The adaptive-compensatory reconstruction is especially well seen at initial stages of the disease. It is manifested as a total dilatation of the bed, certain reserve elements get into work, the bed capacity increases. Then certain new structural units of the bed, collateral pathways develop. When the obturational process lasts long, certain destructive changes of the hepatic lymphatic bed elements take place. The change in the relief of endotheliocytes is their most characteristic sign. With increasing age of the patients the degree of the destructive rearrangements of the hepatic lymphatic bed increases. In the experiment carried out on the animals the lymphatic outflow from the thoracic duct is determined, being an indirect index of the hepatic lymph-forming function. An essential increase of the lymph volume, several times greater than in the control, gets from the duct into the venous bed. A connection is revealed between the morphological transformations of the bed components and its drainage function. The lymphatic bed of the liver performs also an active work concerning resorption and transport of bilirubin, its content in the organ rather increases, when the common bile duct is obturated.

[Microcirculatory bed of the heart during peripheral arteriovenous shunting]. / Mikrotsirkuliatornoe ruslo serdtsa pri perifericheskom arteriovenoznom sbrose krovi.

In the experiment performed on 108 test and 28 control dogs, by means of injection and histological methods, the effect of arteriovenous fistula on the cardiac microcirculatory bed has been studied. The arteriovenous blood shunting results in plethora and stasis in the cardiac microcirculatory bed, in dilatation of all its links, in aggregation and adhesion of the blood formed elements, in increased permeability of microvessels, in diapedesis of erythrocytes and in myocardial edema, in winding microvessels, in development of the venoarterial reaction, in hypertrophy of myocytes, recalibration and sclerosis of the microvascular walls.

[Scanning electron microscope study of the liver microcirculation]. / Mikrotsirkuliatornoe ruslo pecheni po dannym rastrovoi élektronnoi mikroskopii.

During the experimental investigation performed in dogs and rats, by means of scanning electron microscopy of corrosive anatomical preparations, the spatial organization of all parts of the hepatic vascular bed (arterial, venous and lymphatic) has been studied, specific features of their components construction have been described. Within the limits of one hepatic lobule the number of vessels included in the portal vein system exceeds that of the arterial ones, originating from the proper hepatic artery system. In every part of the vascular bed the gradient of the form, orientation and pronouncement of the nuclei-containing zones in endotheliocytes and myocytes has been established. Various appliances participating in the blood and lymph stream regulation in different parts of the vascular bed have been revealed. As initial elements of the lymph bed, closed digital or loop-like capillaries should be regarded, they localize in the organ's connective tissue framework. Around the portal and hepatic veins and their branches, as well as around the biliary ducts, well developed plexuses of the lymphatic and blood capillaries and vessels localize, they are the main draining pathways of the organ. The degree of development and pronouncement of these plexuses depends on the lumen size in the formation they accompany.

[Clinico-laboratory basis for the endolymphatic use of beta-lactam antibiotics in pulmonology]. / Kliniko-laboratornoe obosnovanie éndolimfaticheskogo primeneniia beta-laktamnykh antibiotikov v pul'monologii.

Clinical efficacy and effect of cefuroxime, claforan and pentrexyl used endolymphatically were studied in 85 patients with acute abscess forming and persisting pneumonia. Previous routine antibiotic therapy in these patients was little effective. Administration of the antibiotics into the peripheral lymph nodes provided blocking of the lymphagenic pathway for the infection due to high levels in the lymphatic system. Endolymphatic use of cefuroxime and claforan resulted in a significant improvement of the functions of the T- and B-immunity systems and the indices of natural resistance. The levels of the autoimmune reactions and sensitization to the bacterial antigens decreased. Endolymphatic use of cefuroxime and claforan once every 3 days provided recovery of 9 2.8 per cent of the patients, the treatment periods being decreased 2.5--3 times. Intravenous administration of the drugs according to the routine schemes, endolymphatic use of pentrexyl (5 g once every 3 days) and endolymphatic administration of cefuroxime in a single dose followed by intravenous therapy was less effective. The efficacy of pentrexyl increased, when it was used endolymphatically in combination with lysozyme. Endolymphatic use of claforan in doses of 2--3 g once every 3 days (3--4 infusions during the treatment course) was most effective.

[Endolymphatic antibiotic administration in the combined treatment of peritonitis]. / Endolimfaticheskoe vvedenie antibiotikov v kompleksnom lechenii peritonita.

The endolymphatic method of infusion of antibiotics was used in 165 patients with acute inflammatory diseases of organs of the abdominal cavity, 84,8% of them recovered. A single endolymphatic infusion of a usual dose of the antibiotic makes a very high concentration of the drug in the lymphatic system and maintains a therapeutic concentration of the antibiotic in the lymph during a day. In the lymphatic nodes it retains for more than 2 weeks. The methods reduces acute inflammatory processes, makes the temperature and blood leukocytes normal and improves the general state of the patients resulting in their quicker recovery. The endolymphatic therapy with antibiotics is in good agreement with surgical and other conservative methods of treatment.