[Changes in the biochemical indices of parturients with uterine inertia against the background of therapy]. / Izmeneniia biokhimicheskikh pokazatelei u rozhenits so slabost'iu rodovoi deiatel'nosti na fone terapii.

A comparison was made of some biochemical parameters for energy metabolism, acid-base balance, blood gases and uterine contractility in parturients with uterine inertia who were on therapy with or without hyperbaric oxygenation. The presence of hypoxemia and metabolic acidosis in the parturients was found to intensify the processes of lipid peroxidation, to affect the functional status of myometrial biomembranes, to result in hyperenzymemia and disturbed tissue metabolism and lower myometrial contractility. The use of hyperbaric oxygenation in the multimodality therapy for uterine inertia was ascertained to eliminate oxygen deficiency, to increase tissue respiration, contributing to normal labor.

[Analysis of the correlation of indicators of utero-placental blood flow and various blood enzymes in pregnant women at high-risk of perinatal pathology]. / Analiz korreliatsionnykh sviazei mezhdu pokazateliami matochno-platsentarnogo krovotoka i nekotorymi fermentami krovi u beremennykh s vysokim riskom perinatal'noi patologii.

A study of the correlations between uteroplacental flow (UPF) and some blood enzymes in 117 pregnant patients at high risk for perinatal disorders and with suspected placental insufficiency has demonstrated a stepwise activation of enzyme systems, which are elements of the adaptive-compensatory placental mechanisms, in the presence of placental insufficiency. UPF disorders in the intervillous space are of decisive importance for intrauterine fetal distress, as evidenced by the emerging correlations between UPF, and hydroxibutyrate dehydrogenase and lactate dehydrogenase. For this reason, it is proposed to expand indications for metabolic therapy and hyperbaric oxygenation in order to prevent intrauterine chronic fetal hypoxia.

[Relations between indicators of the activity of several blood enzymes and the state of the utero-placental blood flow in pregnant women at high risk of perinatal pathology]. / Vzaimosviaz' mezhdu pokazateliami aktivnosti nekotorykh fermentov krovi i sostoianiem matochno-platsentarnogo krovotoka u beremennykh s vysokim riskom perinatal'noi patologii.

Studies of the uteroplacental blood flow and of some peripheral blood enzymes activities in 117 pregnant women have revealed that deterioration of the uteroplacental blood flow is associated with an increase of the activities of hydroxybutyrate and lactate dehydrogenases, creatine phosphokinase, and alkaline phosphatase. Exhaustion of the compensatory adaptive mechanisms, that manifests itself by a marked reduction of the blood flow in the intervillous space and by an intrauterine fetal distress is paralleled by a reduction of these enzymes activities.