Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films.

The prospects of using biopolymer nano-containing films for wound healing were substantiated. The main components of biopolymer composites are gelatin, polyvinyl alcohol, glycerin, lactic acid, distilled water, and zinc oxide (ZnO) nanoparticles (NPs). Biopolymer composites were produced according to various technological parameters using a mould with a chrome coating. The therapeutic properties of biopolymer films were evaluated by measuring the diameter of the protective effect. Physico-mechanical properties were studied: elasticity, vapour permeability, degradation time, and swelling. To study the influence of technological parameters of the formation process of therapeutic biopolymer nanofilled films on their therapeutic and physico-mechanical properties, the planning of the experiment was used. According to the results of the experiments, mathematical models of the second-order were built. The optimal values of technological parameters of the process are determined, which provide biopolymer nanofilled films with maximum healing ability (diameter of protective action) and sufficiently high physical and mechanical properties: elasticity, vapour permeability, degradation time and swelling. The research results showed that the healing properties of biopolymer films mainly depend on the content of ZnO NPs. Degradation of these biopolymer films provides dosed drug delivery to the affected area. The products of destruction are carbon dioxide, water, and a small amount of ZnO in the bound state, which indicates the environmental safety of the developed biopolymer film.

Mathematical Modelling of Destabilization Stress Factors of Stable-Elastic Fixation of Distal Trans- and Suprasyndesmotic Fibular Fractures.

Introduction: Specification of possible stress factors destabilizing the fibula stable osteosynthesis by the intramedullary nail with distal blocking and elastic fixation of distal syndesmosis by the thread with endobuttons by mathematical modelling of distal unstable ankle injuries. Material and Methods. We studied the thread tension during the combined stable-elastic fixation of unstable injuries of the ankle joint in cross-syndesmosis fractures of the fibula (B, C Danis-Weber classification), which includes a one-time stable minimally invasive fixation with the intramedullary nail and elastic fixation by the thread with endobuttons. We used a titanium alloy for the intramedullary nail and polyester for the thread. The deformed state was studied using the methods of mechanics. Results: A model of a fractured fibula blocked with the intramedullary nail and fixed with the elastic thread was developed. A formulation to specify the rational tension forces of the elastic thread depending on the parameters of the fibula and intramedullary blocking nail and on the location of the bone injury was obtained. The effect of foot rotation on the thread tension was investigated. The results of theoretical research should be implemented in medical practice. Conclusions: A mathematical model of the damaged fibula blocked by the intramedullary nail and fixed with the elastic thread was developed. Dependences for calculation of tension of the fixing thread were obtained. A slight increase in thread tension during foot rotation was found.