RESUMO
Purpose: The aim of this study was to evaluate the effects of aerobic training on motor cortical areas in multiple sclerosis (MS) patients, based on task-based functional magnetic resonance imaging (t-fMRI) as well as on brain activity at rest, according to resting state functional MRI (rs-fMRI) studies. Material and methods: Multiple sclerosis patients were divided into 2 groups consisting of 14 participants each: the MS study group and the MS control group. All MS patients underwent clinical assessment and MRI examination, twice: in the MS study group at the time of inclusion in the study and after a 4-week period of aerobic training, whereas in the MS control group it happened at the time of inclusion and after a period of one month without exercise rehabilitation. The MRI study protocol included rs-fMRI and t-fMRI sequences, which were the grounds for an analysis of resting state networks (RSN) as well as peak level and cluster level parameters within motor cortex areas - the primary motor cortex, premotor area, and supplementary motor area, respectively. Results: In the MS study group, aerobic training improved the clinical condition and decreased the functional correlation between the sensorimotor network and the salience network. Also, significant decreases of the mean cluster level (72.42 vs. 38.35) and peak level values (10.89 vs. 7.64) were observed in the contralateral primary motor cortex in this group of patients between examinations. Conclusions: Aerobic training not only improves physical performance but also contributes to changes in brain activity - both within RSN and motor cortex areas in MS patients.
RESUMO
Purpose: The aim of this study was to assess the activity of motor cortical areas and the resting brain activity in a group of multiple sclerosis (MS) patients compared to a group of healthy individuals according to task-based functional magnetic resonance imaging (t-fMRI), resting state functional MRI (rs-fMRI), and volumetric MRI studies. Material and methods: The study enrolled 28 MS patients and 20 healthy volunteers who underwent MRI examinations. Primary motor cortex (M1), premotor area (PMA), supplementary motor area, as well as resting state networks (RSN's) and volumes of selected brain structures were subjected to a detailed analysis. Results: In MS patients, a motor task more often resulted in the activation of ipsilateral M1 cortex (observed in 39% of the studied group) as well as the PMA cortex (observed in 32% of MS patients). No differences in resting brain activity were found between the studied groups. Significant differences were observed in volumetric parameters of the total brain volume (healthy volunteers vs. MS patients, respectively): (1197 cm³ vs. 1150 cm³) and volumes of the grey matter (517 cm³ vs. 481 cm³), cerebellum (150 cm³ vs. 136 cm³), thalamus (16.3 cm³ vs. 12.6 cm³), putamen (8.9 cm³ vs. 7.7 cm³), and globus pallidus (4.57 cm³ vs. 3.57 cm³). Conclusions: In the MS patients, the motor task required significantly more frequent activation of the primary and secondary ipsilateral motor cortex compared to the group of healthy volunteers. The rs-fMRI study showed no differences in activity patterns within the RSN's. Differences in the total cerebral volume and the volume of the grey matter, cerebellum, thalamus, putamen, and globus pallidus were observed.