1.
Bioorg Med Chem Lett
; 14(16): 4307-11, 2004 Aug 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15261292
RESUMO
A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In addition, one of the compounds exhibits oral activity in a rat adjuvant arthritis model.