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J Coll Physicians Surg Pak ; 22(3): 139-42, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22414351

RESUMO

OBJECTIVE: To assess the nutritional status via the SGA (subjective global assessment) screening tool of patients at all stages of hepatitis C virus (HCV) liver disease. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Out-patient Clinics of the Aga Khan University Hospital, Karachi, conducted from October 2009 to January 2011. METHODOLOGY: Patients with hepatitis C virus infection and their HCV-negative attendants were enrolled from the outpatient clinics, and categorized into 4 groups of 100 patients each: healthy controls (HC), those with chronic hepatitis C infection (CHC), compensated cirrhotics (CC) and decompensated cirrhotics (DC). The validated subjective global assessment (SGA) tool was used to assess nutritional status. RESULTS: A total of 400 patients were enrolled. Most of the patients in the HC group were class 'A' (best nutritional status). In contrast, the majority (64%) in the DC group were in the class 'C' (worst status). The compensated cirrhosis (CC) group showed that 90% of patients were malnourished, while 98% of all patients were malnourished in the DC group, predominantly class 'C'. Most importantly, 14% of patients with chronic hepatitis C (CHC) also scored a 'B' on the SGA; which when compared to HC was statistically significant (p=0.005). As the groups progressed in their disease from CHC to DC, the transition in nutritional status from 'A' to 'C' between groups was statistically significant. CONCLUSION: Malnutrition occurs early in the course of HCV, and progresses relentlessly throughout the spectrum of HCVdisease.


Assuntos
Hepatite C Crônica/epidemiologia , Desnutrição/etiologia , Avaliação Nutricional , Estado Nutricional , Adulto , Feminino , Seguimentos , Hepatite C Crônica/complicações , Humanos , Masculino , Desnutrição/epidemiologia , Pessoa de Meia-Idade , Pacientes Ambulatoriais , Paquistão/epidemiologia , Prevalência , Estudos Prospectivos , Índice de Gravidade de Doença
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