RESUMO
The effect of the high therapeutic doses of diazepam on the histology and ultrastructure of the mice muscular tissue was investigated. Diazepam administration caused obvious histological and ultrastructural alterations in sartorius muscle fibers; distortion of their normal architecture was clearly observed. The sartorius muscle showed obvious enlargement of the nucleus, small and degenerated myofibrils, small, few and disorganized mitochondria, decrease of glycogen granules increase of fat vacuoles and destruction and dilation of SR, large interfibrillar spaces. Moreover, sartorius muscle revealed increase and vacuolation of connective tissue between the muscle fibers. Connective tissue contained dilated and congested blood capillaries, macrophages and many fibroblasts. In addition, disorganized myoneural junctions were noticed. Empty and dilated axons were noticed at the myoneural junction.
