The extent of ionization in simulations of radio-loud AGNs impacting kpc gas discs.

We use the results of relativistic hydrodynamic simulations of jet-interstellar medium (ISM) interactions in a galaxy with a radio-loud AGN to quantify the extent of ionization in the central few kpcs of the gaseous galactic disc. We perform post-process radiative transfer of AGN radiation through the simulated gaseous jet-perturbed disc to estimate the extent of photo-ionization by the AGN with an incident luminosity of 1045 erg s-1. We also map the gas that is collisionally ionized due to shocks driven by the jet. The analysis was carried out for simulations with similar jet power (1045 erg s-1) but different jet orientations with respect to the gas disc. We find that the shocks from the jets can ionize a significant fraction (up to 33 [Formula: see text]) of dense gas ([Formula: see text]) in the disc, and that the jets clear out the central regions of gas for AGN radiation to penetrate to larger distances in the disc. Jets inclined towards the disc plane couple more strongly with the ISM and ionize a larger fraction of gas in the disc as compared to the vertical jet. However, similar to previous studies, we find that the AGN radiation is quickly absorbed by the outer layers of dense clouds in the disc, and is not able to substantially ionize the disc on a global scale. Thus, compared to jet-ISM interactions, we expect that photo-ionization by the AGN radiation only weakly affects the star-formation activity in the central regions of the galactic disc (≲ 1 kpc), although the jet-induced shocks can spread farther out.

Immunological tolerance and tumor rejection in embryo-aggregated chimeric mice - lessons for tumor immunity.

BACKGROUND: Rejection of transplanted tumors by the immune system is a rare event in syngeneic hosts, and is considered to be dependent on the local interaction of defensive immune reactions and tumor tolerance mechanisms. Here, we have enlisted the aid of a unique set of embryo-aggregated lineage chimeric mice derived from C57/BL6 and FVB donors to study the interplay between local and systemic tumor immunity and tolerance in rejection of mouse B16 melanoma cells, syngeneic to the C57/BL6 donor strain. METHODS: Two variants of embryo-aggregated chimeric mice with either variable or no contribution of C57-derived cells to their skin were generated by the fusion of different ratios of morula stage blastomers. Chimeric mice were analyzed for s.c. growth of B16 tumors in comparison to their respective donor strains as well as normal F1 hybrids, and the relative frequencies of cellular components of the immune system by FACS analysis of peripheral blood or lymph node cells. RESULTS: B16 tumors grew significantly faster in mice with full chimerism in their skin as compared to syngeneic C57 or semi-syngeneic C57 x FVB F1 hosts. In contrast, s.c. tumor growth was either absent or significantly reduced in chimeric mice lacking C57-derived cells in their skin, but tolerant to C57 tissue in other organs. Comparison of the relative frequencies of various immune cells in the periphery via FACS-analysis did not reveal any significant differences between the two types of chimeric mice with respect to their donor strains. CONCLUSION: Our data suggest a complex interplay between mechanisms of local peripheral tolerance and innate antitumor mechanisms possibly involving NK cell allorecognition as a basis for the differential growth or rejection of B16 tumors in these unique chimeric mice, which we suggest to constitute a valuable new model system for the study of immune-mediated tumor rejection.