Management of Essential Thrombocythemia in a Patient With a History of Thrombotic Thrombocytopenic Purpura.

This case presents a patient with two transposed rare diagnoses developed within 10 years. Thrombotic thrombocytopenic purpura (TTP) and essential thrombocythemia (ET) are disease processes that present with opposite clinical and laboratory findings. The patient was diagnosed with ET over a decade after the initial TTP diagnosis when she was found to have extreme thrombocytosis during routine laboratory monitoring. The patient was found to have the calreticulin (CALR) mutation variant of ET which is associated with increased platelet production and she was started on hydroxyurea and aspirin. Subsequent management of the patient's TTP relapses and large fluctuations in her platelet counts necessitated adjustments to the standard ET treatment regimen. There is little to no literature on this rare comorbidity and further investigation is needed for the association between these diseases and modifications to standard treatment to prevent relapses and sequelae.

Examination of Cutaneous Changes Among Patients Following SARS-CoV-2 Infection.

Individuals infected with SARS-CoV-2 have been found to develop a variety of cutaneous symptoms. This study sought to describe varying cutaneous manifestations of COVID-19 in individuals presenting to an inpatient healthcare facility. We screened individuals who presented with COVID-19 for skin changes throughout the illness and administered a survey regarding demographics, medical history, and their cutaneous findings. Three individuals reported varying skin findings including wheals, petechiae, ecchymosis, and papules. One individual reported a worsening skin condition, psoriasis, as well as a new skin condition, seborrheic dermatitis. In conclusion, cutaneous manifestations of patients suffering from COVID-19 are wide-ranging and worsening skin conditions amongst these patients should be further investigated.

Large Mucocele of the Appendix Discovered in a 48-Year-Old Male Presenting With Appendicitis: A Case Report.

The appendix is a vermiform-like organ that extends from the cecum and has been thought of as having a rudimentary immunologic function. However, the appendix can become distended and mucus-filled, classifying it as a mucocele appendix. Mucoceles can be found in various locations in the body, including the colon and the appendix, and have malignancy potential. We report a case of a 48-year-old male that presented to the ED with a history of two days of abdominal pain. Upon arriving at the ED, he had a CT scan showing a 9.5 x 4.2 x 6.4 cm fluid collection in the right lower quadrant (RLQ) juxtaposed to the cecum, suggesting appendicitis or an abscess. Initially, a laparoscopic approach was taken, which was then converted to an open laparotomy. The mass was excised and a right hemicolectomy was performed along with an ileocolonic anastomosis due to extensive involvement of the large intestine. Pathology reported a low-grade appendiceal mucinous neoplasm resected with negative margins and 16 negative lymph nodes.

Food Bolus Masquerading as a Cardiac Mass on Echocardiogram.

An echocardiogram is the most utilized imaging modality in the evaluation of patients with intracardiac masses. Of these, left atrial myxomas are the most common intracardiac tumors in which diagnostic recognition is important for appropriate management. This paper demonstrates a case study on how a proper physical exam along with proper imaging modalities may result in avoiding misdiagnosing patients with large sliding hiatal hernias who present with the complaint of chest pain. This case reveals a food bolus within a sliding hiatal hernia masquerading as an intracardiac mass. Cardiac masses can potentially be misdiagnosed using transthoracic echocardiography (TTE). While transthoracic echocardiography is uniquely resourceful as a point-of-care modality, it can be challenging to confirm whether an identified mass is attached to the myocardium or other cardiac or intrathoracic structures. The patient exhibited symptoms compatible with a cardiac mass. Primarily, the physical examination is vital in determining whether the patient should be referred for additional diagnostic modalities to assess for a cardiac mass. Auscultation of bowel sounds on the cardiac examination is consistent with a suspected hiatal hernia.