Study on Body Mass Index, Serum Total Cholesterol and Serum Triglycerides in Adult Male Hypertensive Patients.

Hypertension or elevated blood pressure is a serious medical condition that significantly increases the risks of heart, brain, kidney and other diseases. An estimated 1.28 billion adults aged 30-79 years worldwide have hypertension, most (two-thirds) living in low- and middle-income countries. An estimated 46.0% of adults with hypertension are unaware that they have the condition. In Bangladesh, 21.3 million of the adult population has hypertension and that is 21.0% of total population. About half of them (48.7%) with hypertension are diagnosed and 34.9% are under treatment. One of the global targets for non communicable diseases is to reduce the prevalence of hypertension by 33.0% between 2010 and 2030. This study was done to evaluate the effects of hypertension and to find out the major complications occurring due to hypertension. This analytical type of cross sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from January 2021 to December 2021. A total number of 120 male subjects, age ranged from 20-59 years was included in this study. Among them, sixty (60) hypertensive subjects were taken as study group (Group II) and sixty (60) ages matched normotensive adult male subjects were taken as control group (Group I). The results were calculated and analyzed by using Statistical package for social science (SPSS). Anthropometric measurements such as height and weight were taken in meter and kilogram respectively. Systolic and diastolic blood pressure were measured by Aneroid Sphygmomanometer (ALPK2, Japan), laboratory analysis of fasting serum total cholesterol by CHOD-POD method, fasting serum triglycerides by GPO-POD method. In this study we found that in study group Mean±SD of body mass index (29.36±2.60, p<0.001), fasting serum total cholesterol (232.05±11.18, p<0.001) and fasting serum triglycerides (180.67±19.44, p<0.001) which were significantly increased with comparison to control group. It's concluded from this study we recommended that routine estimation of these parameters is important for prevention of complication related to hypertension for leading a healthy life.

Trend of Carcinoma of the Stomach in Relation to Site, Age and Aetiology: Study of 112 Cases in a Tertiary Level Hospital.

Stomach cancer is the fourth most common cancer worldwide, but due to its poor prognosis, it is the second most common cause of cancer deaths worldwide. The incidence of carcinoma of gastric cardia is found to be increasing, while that of the antrum is seen to be decreasing. Data from Bangladesh is lacking on this aspect. The objective of this study was to understand the trends of frequency and localization of gastric cancers arising from the gastric cardia, body and antrum of the stomach in population of Bangladesh, which may enable us to identify important high risk populations, prevention strategies, and ultimately best treatment strategies. This cross sectional descriptive hospital record based study was conducted in Mymensingh Medical College Hospital during the period of June 2010 to January 2011. Data were collected from hospital records of 112 cases with carcinoma of stomach, confirmed by histopathology, admitted in Mymensingh Medical College Hospital during January 2007 to June 2010. Data collection, compilation, statistical analyses were performed manually. In this study 54.46% cases are in the age group of 50-60 year, mean age was 57.23 year and standard deviation was 57.37 and the second highest (31.25%) was in the age group of 61-70 year. Incidence of gastric carcinoma predominates in male. In this study 81(72.32%) patients were male and 31(27.68%) patients were female. Male to female ratio is 2.61:1. Majority 80(71.43%) of patients were smoker and 32(28.57%) patients were nonsmoker. Majority of the patients 90(80.36%) came from lower socioeconomic group, 19(16.96%) patients were from middle socioeconomic group and 3(2.68%) patients were from high socio-economic group. There is a link between diet and carcinoma stomach, suggested in various study. Here, 112(100%) took carbohydrate as the staple food. Salt preserved dried fish also was present in a significant number of patients 100(89.29%). Vegetables and fresh fruits were taken by 80(71.42%) patients. Antral region was involved in 65(58.03%) cases. In 28(25%) cases the lesion was in the body of the stomach. Cardiac end of the stomach was involved in only 19(16.97%) cases. Following histopathology, poorly differentiated carcinoma was found in 68(60.71%) patients well differentiated carcinoma in 24(21.43%) and moderately differentiated carcinoma in 20(17.86%) patients. This study found that stomach cancer in Bangladesh showed characteristics which are similar to other nations. As carcinoma stomach is one of the important causes of cancer mortality, and as there is no population based study in our country, further study needed and therefore it remains a major public health concern in need of prevention strategies.

Clinicopathological Assessment of Colorectal Carcinoma in Mymensingh Medical College Hospital, Bangladesh.

Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation. This cross-sectional, descriptive study was intended to explore the age and sex distribution, pattern of presentation, sites and histological types of colorectal carcinoma. This cross-sectional, descriptive study was conducted in the department of surgery, Mymensingh Medical College Hospital, Bangladesh from October 2011 to September 2012. Purposively selected sixty patients irrespective of age and sex with histologically proven colorectal cancer were included in the study. A pre-tested, structured case record form was used for collection of data. Most of the patients (80.0%) were above 50 years of age. Mean age was 60.83 years with an SD of 11.2 years. Male to female ratio was almost equal (1.3:1). Positive family history was present in 3.3% cases. More than half of the patients (53.3%) were smokers, 76.7% patients had the history of taking fresh fruits irregularly. Pain in abdomen was the leading symptom followed by alteration of bowel habit and weight loss. Anaemia was found in 71.6% patients followed by wasting in 70.0% cases. Proctosigmoidoscopy was the principal diagnostic modality (61.7%) followed by double contrast barium enema (30.0%). Patients with rectal growth were detected by digital rectal examination (23.3%). Rectum was the principal site of cancer (36.7%) followed by sigmoid colon (33.3%). Cancer in caecum and ascending colon were in 15.0% and 6.7% patients respectively. Adenocarcinoma was the principal histological type (88.0%) and 36.7% were well differentiated carcinoma. Majority of the patients (63.3%) were in advanced stage (stage III and stage IV). Some forms of palliative surgical treatment were offered to all colorectal cancer patients in the study. Postoperative outcome was uneventful in most of the patients. However, there was wound infection in (13.3%) patients. Colorectal cancer was found mainly in elderly. Male and females were affected almost equally. Smoking was the most commonly found risk factor. Colorectal carcinoma involved rectum and sigmoid colon in majority of the patients. Adenocarcinoma was the principal histological type and the most of which were well differentiated. Majority of the patients were diagnosed at an advanced stage and palliative treatment was offered to them. Postoperative period was uneventful in most of them. Policies should be taken to promote health education & screening programmes which will lead to early diagnosis, affordable and effective treatment and better prognosis.

Effect of Obesity on Fasting Blood Sugar.

Obesity is a disorder of body weight regulatory systems characterized by an accumulation of excess body fat. World Heath Organization recommended that 66% of deaths now occur in developing countries and recognizes obesity as a leading risk factor. Obesity is associated with chronic, low grade, systemic inflammation. The inflammatory state plays a causal role in the development of insulin resistance, type 2 diabetes and the metabolic syndrome. This study will design to evaluate the relation between obesity with fasting blood sugar (FBS). This descriptive type of cross sectional study had been performed to investigate the relationship between obesity with serum fasting glucose, of 100 obese and 100 normal weight persons from both sexes, aged between 25 to 60 years will be selected from Mymensingh Medical College, Mymensingh, Bangladesh and locality from July 2014 to January 2016. Data are collected through a simple questionnaire after informed consent taken. The result was calculated and analyzed by using SPSS (statistical package for social science, version 11.5). Statistical significance of difference between two groups was evaluated by unpaired Student's 't' test. Data were expressed as Mean±SE. P value less than 0.05 was taken as the level of significance. Anthropometric measurements such as height and weight were taken in meter and kilogram respectively. Pulse, systolic and diastolic blood pressure was measured by aneroid sphygmomanometer (ALPK2, Japan), laboratory analysis of serum fasting glucose will be estimated by GOD-PAP Method. In this study we found that fasting serum glucose is significantly increased in both male and female obese persons 4.07±0.79mmol/l & 5.58±0.64mmol/l respectively. In obese the values of FBS indicate the subjects are prone to develop cardiovascular & metabolic diseases. That has high morbidity and mortality. Therefore, by this study we recommended that routine estimation of fasting blood sugar is important for prevention of complication related to obesity for leading a healthy life.

Relationship of Hemoglobin Concentration in Adult Asthmatic Patients.

Asthma is a chronic inflammatory disorder of the airways, in which many cells and cellular elements play a role. Asthma is one of the most common diseases globally and currently affects 300 million people. The epidemic rise in anemia, asthma, and related allergic disease is a common major public health problem worldwide. Asthma and anemia associated with acute infections occur both in children and adults. This descriptive type of cross sectional study was done to find out the levels of hemoglobin concentration in adult asthmatic patients and carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2014 to January 2016. Fifty (50) male and 50 (fifty) female adult asthmatic patients aged 18-60 years were included in the study group. They are enrolled from the Department of Medicine, Mymensingh Medical College, Mymensingh, Bangladesh and also from locality. For comparison age matched 50 male and 50 female apparently healthy persons were also studied as control. Hemoglobin concentration was estimated by Cyanmethemoglobin method. For statistical analysis unpaired student's 't' test was used. Mean hemoglobin concentration was significantly decreased in study group in comparison to control group and the result was statistically significant (p<0.001). The study findings showed a high prevalence of anemia among asthmatic patients than non asthmatic healthy persons.

Blood Pressure in Third Trimester of Pregnancy.

Pregnancy is a great stressful physiological condition in women during their reproductive period. During pregnancy several hemodynamic, biochemical and hematological modifications occur as a part of the physiological adaptation of the body. Changes in blood pressure occur in third trimester of pregnancy, which may be associated with increased maternal and infant mortality and morbidity. This cross-sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, from July 2013 to June 2014. Study subjects were selected by following purposive sampling procedure and the protocol of this study was approved by Institutional Ethics Committee (IEC) of Mymensingh. This study enrolled 100 pregnant women of third trimester of pregnancy and 100 aged matched non-pregnant women from Mymensingh district. Mean systolic blood pressure in study group were 124.8±14.51 mm of Hg and in control group were 106.50±10.67 mm of Hg, which was statistically increased. Diastolic blood pressure in study group was 83.00±13.37 mm of Hg and in control group 71.05±7.12 mm of Hg, which was also statistically significant. The changes in blood pressure in third trimester of pregnancy is the major concern of developing the risk of pre-eclampsia & eclampsia, and increased prevalence of IUGR, pre-maturity and perinatal mortality. This study reveals significant changes of blood pressure during third trimester of pregnancy.

Variations of Weight of Thyroid Gland in Different Age and Sex Groups of Bangladeshi Cadavers.

A cross sectional descriptive study was designed to find out the difference in weight of the thyroid gland of Bangladeshi people in relation to age and sex. The present study was performed on 70 post mortem human thyroid gland (35 of male and 35 of female) collected from the morgue in the Department of Forensic Medicine, Mymensingh Medical College, Mymensingh by purposive sampling technique. The specimens were collected from Bangladeshi cadavers of age ranging from 10 years to 85 years. All the specimens were grouped into three categories Group A (upto 20 years), Group B (21 to 50 years) and Group C (>50 years) according to age. Dissection was performed according to standard autopsy techniques. The weight of the thyroid glands were measured and recorded. The mean weight of the thyroid gland was 6.94 ± 5.20 gm in Group A, 7.91 ± 5.89 gm in Group B and 10.42 ± 6.27 gm in Group C. The mean weight of the thyroid gland in male was 7.0 ± 5.77 gm in Group A, 9.94 ± 7.63 gm in Group B and 11.89 ± 5.73 gm in Group C and in female was 6.88 ± 4.88 gm in Group A, 5.88 ± 2.15 gm in Group B and 9.10 ± 6.74 gm in Group C. Variance analysis shows that there was no significant difference in mean weight between the Age Group A & B, B & C and C & A. There was significant difference of weight of thyroid gland between sex in age Group B but in Group A and Group C were statistically insignificant. The weight of the thyroid gland was found to increases with age. In statistical analysis, differences between age groups were analyzed by using one way ANOVA test. The present study will help to increase the information pool on the weight of thyroid gland of Bangladeshi people.

Morphometry of isthmus of thyroid gland in Bangladeshi cadaver.

This cross sectional descriptive study was carried out to determine the length, breadth & thickness of isthmus of thyroid gland of Bangladeshi people. To fulfill this aim sixty postmortem tissue blocks containing thyroid gland and its neighbouring structures were collected by convenience sampling technique from 48 male and 12 female cadavers of different age groups, age ranging from 11 to 70 years and fixed and preserved in 10% formol-saline solution. Specimens were collected from dead bodies autopsied on different dates from October'2004 to February'2005 at the autopsy laboratory of Forensic Medicine Department of Mymensingh Medical College, Mymensingh, Bangladesh. Gross and fine dissection was carried out to study the length, breadth and thickness of isthmus of thyroid gland. In the present study, observed findings were compared with those of Western and Bangladeshi researchers. It was seen that the mean±SD lengths of isthmus were 10.42±7.49 mm, 10.17±5.70 mm and 9.33±6.64) mm in Group A(upto 18 years), B(19 to 45 years) and C(>45 years) respectively. Highest length (30mm) was observed in Group A and lowest length (2mm) was observed in Group C. Variance analysis showed that there was no significant difference in mean length between the age groups (F=0.086, p=0.918). The mean±SD values of breadth were 13.66±5.06 mm, 14±5.41 mm and 12.27±3.97 mm in Group A, B and C respectively. In the ranges, there was much overlapping among the groups. In Group B breadth of the isthmus was greater than other age groups. But these differences were statistically not significant, where F=0.430 & p=0.654. It was interesting to note that in this study the mean breadth of isthmus was significantly greater than the mean length (where, t=-2.727 and p=0.01). In the present study the mean±SD thickness of the isthmus of thyroid glands were 4.91±1.78 mm, 4.72±2.68 mm and 4.45±1.36 mm in three age groups respectively & the thickness of isthmus of thyroid gland was also greater in Group B than other two groups. But the variance analysis reveals that, there was insignificant difference in the thickness (F=0.133, p=0.876) of isthmus of thyroid gland among different age groups.

Drop-out and admission cancel rate among the students in a selected medical college.

A record based descriptive type of study was carried out among the under-graduate students of Mymensingh Medical College from the session 1966-67 to 2006-07. The academic years were divided into four decades and admission was followed into three categories such as retained, cancellation and drop-out. Total number of the students was 5892. Among them 3848(65.30%) were male and 2044(34.69%) were female. Out of 5892 students drop-out was 282(4.78%) and admission cancel was 304(5.15%). It was also found that drop-out in male was 232(6.02%) and in female was 50(2.44%) and admission cancel in male was 266(5.87%) and in female was 78(3.81%). The difference was found statistically significant (p<0.001). It was observed that gradually the drop-out and admission cancel rate is decreasing from the very beginning to till now. It was also observed that all drop-out and admission cancellation were in first & second year students. There was no continuation of their class roll numbers in third year registration.

Gestational anemia.

Gestational anemia is a common public health problem in our country. Most anemia during pregnancy results from an increased need for iron as her body is making more blood. Often dietary supplementation does not provide enough iron to meet the extra needs. Also the growing baby takes all the iron it needs from mother, regardless of how much iron is stored in mother's blood. Gestational Anemia contributed significantly to maternal morbidity and mortality, IUGR, preterm delivery and perinatal morbidity and mortality. A high proportion of women in both industrialized and developing countries become anemic during pregnancy. The most important cause of gestational anemia due to iron deficiency, because high iron requirements during pregnancy are not easily fulfilled by dietary intake. Adequate iron stores can help a pregnant women replace lost red blood cells. So, iron supplementation is strongly recommended for all pregnant women in developing countries. Oral iron intake is the treatment of choice and almost all pregnant women can be treated effectively with oral iron preparation during their pregnancy period.

Fact of low hemoglobin and packed cell volume in pregnant women are at a stand still.

A cross sectional descriptive type of study was done in 98 women of reproductive age. Among them 25 were in control group of non pregnant women and 73 were pregnant women of 1st, 2nd and 3rd trimester of pregnancy with and without iron supplementation. The period of study was July 2004 to June 2005. The main objective of our study was to compare hemoglobin percent and packed cell volume (PCV) in pregnant and non pregnant women. In present study hemoglobin percent and packed cell volume was significantly decreased in 2nd and 3rd trimester of pregnancy when compared with the control group and same category of women who were not supplemented with iron. It is evident that the significantly low hemoglobin percent and packed cell volume (PCV) in pregnant women is due in part to dietary iron deficiency. Therefore, iron therapy in pregnancy is helpful to maintain the hemoglobin percent and packed cell volume nearer to that of non pregnant normal women.

Persistence of low serum iron and high total iron binding capacity in pregnant women.

A cross sectional descriptive type of study was done in 98 women of reproductive age. Among them 25 were in control group of non pregnant women and 73 were pregnant women of 1st, 2nd and 3rd trimester of pregnancy with and without iron supplementation. The period of study was July 2004 to June 2005. The main objective of our study was to compare serum iron and total iron binding capacity in pregnant and non pregnant women. In present study serum iron was significantly increased in 2nd and 3rd trimester of pregnancy that was supplemented with iron when compared with the same category of women who were not supplemented with iron. On the other hand serum total iron binding capacity (TIBC) was significantly increased in 3rd trimester of pregnancy that was not supplemented with iron when compared with the same category of women who were supplemented with iron. It is evident that the significantly low serum iron and high TIBC in pregnant women is due in part to dietary iron deficiency. Therefore, iron therapy in pregnancy is helpful to maintain the serum iron and TIBC nearer to that of non pregnant normal women.

Studies on serum lipid profile in hypertensive patient.

UNLABELLED: The study was carried out to appraise the serum total cholesterol, triglyceride, HDL-C and LDL-C values in hypertensive patients for providing information to the health-policy planners and also to the clinical practitioners about the importance of routine monitoring of lipid profile in hypertensive patients for prevention of coronary heart disease and other consequences to combat morbidity and mortality and to reinforce the need to consider these parameters in daily clinical practice. It was a cross-sectional study. The study was conducted at Department of Physiology and Biochemistry of Mymensingh Medical College, Medicine Unit of Mymensingh Medical College Hospital and in the community of Sadar, Mymensingh District. The period of the study was January 2005 to December 2005. A total number of seventy subjects were included in this study. Out of them 40 (forty) were hypertensive patients and 30 (thirty) were normotensive & healthy controls. Most of the hypertensive patients (65%) were taking treatment irregularly. Serum total cholesterol, serum triglyceride and serum LDL cholesterol were greater in hypertensive than those of normotensive . The differences of mean of serum total cholesterol, serum LDL cholesterol in between two groups were statistically significant and in case of serum triglyceride it was statistically highly significant. Serum HDL cholesterol was less in hypertensive than those of normotensive. The differences of mean of serum HDL cholesterol in between two groups were statistically highly significant. Among 40 hypertensives the number of "Getting treatment- regular" & "Getting treatment-irregular" was 14 (35%) & 26 (65%) respectively and the values are not statistically significant. Similarly in patients "suffering less than 5 years" and "suffering 5 years & above" the differences are also not statistically significant. CONCLUSION: The observations of this study has revealed that most of the hypertensive patients are taking treatment irregularly and there was significant alteration of serum cholesterol, triglyceride, HDL-C and LDL-C in hypertensive patients. Therefore, for routine monitoring of hypertensive patients to prevent the coronary heart disease (CHD) and other consequences, the reinforcement of the investigations of these parameters may be recommended in daily clinical practice.