Assuntos
Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Desinfetantes/efeitos adversos , Conservantes Farmacêuticos/efeitos adversos , Europa (Continente)/epidemiologia , Feminino , Seguimentos , Formaldeído/efeitos adversos , Humanos , Masculino , Metenamina/efeitos adversos , Metenamina/análogos & derivados , Nitrilas/efeitos adversos , Parabenos/efeitos adversos , Testes do Emplastro , Tiazóis/efeitos adversos , Ureia/efeitos adversos , Ureia/análogos & derivadosRESUMO
A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested.
Assuntos
Alérgenos , Anti-Inflamatórios/administração & dosagem , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/prevenção & controle , Irritantes , Níquel , Testes do Emplastro/métodos , Prednisona/administração & dosagem , Administração Oral , Estudos Cross-Over , Método Duplo-Cego , Europa (Continente) , Feminino , Humanos , MasculinoRESUMO
Irritant contact dermatitis is defined as a non-immunological skin reaction following exposure to various chemical, mechanical and physical factors. It is known that the skin response to irritants depends on the irritant applied and differs between chemically different irritants. Sodium lauryl sulfate (SLS) is an anionic detergent and the most frequently used substance in experimental irritant contact dermatitis. In 1980, it was suggested that nonanoic acid (NNA) could be used as a positive control when patch testing. Since then, NNA has been used as an experimental irritant in several studies and has been used as a chemically different substance compared to SLS. The present article presents a review of the application of NNA in studies on skin irritancy and experimental irritant contact dermatitis.