Urinary excretion of beta 2-microglobulin in myeloma patients.

The levels of beta 2-microglobulin in urine and serum were determined in 39 patients with myelomatosis. In 25 patients the serum beta 2-microglobulin was elevated, and in seven of the patients with increased serum beta-microglobulin the urinary excretion of the protein was also increased. It was concluded that the increased urine beta-microglobulin indicates a renal tubular disorder.

Urine B2-microglobulin in patients with macroglobulinemia Waldenström.

The level of B2-microglobulin in the urine was determined by a radioimmunoassay technique in six patients with Waldenström's macroglobulinemia. In 50% of the patients the B2-microglobulin in the urine was significantly increased. In none of the analyzed patients any glomerular malfunction, as measured by serum creatinine and creatinine clearance, was observed.