RESUMO
BACKGROUND & OBJECTIVE: PCOS is the one of the frequently diagnosed endocrine syndrome in Pakistani women. However, little attention has been devoted to empirical investigation of the role of sexual dysfunction in developing depressive symptoms and reducing life satisfaction. Our objective was to determine the contribution of Sexual dysfunction in developing depressive symptoms and life dissatisfaction in females diagnosed with PCOS. METHODS: This correlation study was carried out from 1st September 2019 to 15th February 2020 at COMSATS University Islamabad, Lahore Campus. A sample of 60 women with PCOS between reproductive age 18 - 38 years (Mage = 27.86, SD = 4.58) was selected through purposive sampling technique from the government hospitals of Lahore, Pakistan. The participants responded to a Demographic Information Form, Female Sexual Functioning Index, Siddiqui Shah Depression and Life Satisfaction Scale. RESULTS: Correlation analysis revealed significant positive link of sexual dysfunction with depressive symptoms and negative link with life satisfaction level. Further, regression analysis revealed sexual functioning as significant predictor of depressive symptoms only. CONCLUSION: Sexual dysfunction play a major role in general mental health of females, therefore, screening and identification as well as preventive measure need to be introduced at early level of development. In addition, current study findings suggest that once females are diagnosed with PCOS, they should be provided sufficient counselling services in order to deal with depressive symptoms and feeling of low life satisfaction. Further, targeted interventions and counselling services may also facilitate in optimising patient care.
RESUMO
Niosomes has gained tremendous popularity as ultimate drug carrier. Lot of research work is being carried out on preparation of niosomes for ophthalmic use having no significant effect on vision and its sustained release pattern. Chloramphenicol niosomes were prepared using two different ratios of cholesterol, drug and surfactant, termed as EIN-1, EIN-2 by ether injection method and their entrapment efficiency, particle size. The in vitro drug release pattern was observed for ten hours. The EIN-2 showed 90% entrapment and released 81% of entrapped drug after 10 hours. Zeta potential & viscosity were determined and in-vivo comparison was made with Chloramphenicol eye drops where it exhibited Cmax of 15 µ g/ml. Stability studies were done to determine shelf life. MIC of selected strain of S. aureus was also determined. EIN 2 niosomal suspension was compared with Chloramphenicol eye drops in experimental conjunctivitis in albino rabbits. In-vitro studies are encouraging as niosomes released about 75% of total entrapped drug by EIN-1 and 81% of total entrapped drug by EIN 2. In vivo study shows that niosomes released the drug in eye in acceptable range and showed a sustained release pattern without affecting the vision. Niosomes were found ultimate ophthalmic drug carriers capable to release drug in sustained and determined pattern.
