Short-term effects of the chemical components of fine particulate matter on pulmonary function: A repeated panel study among adolescents.

The effects of the chemical components of fine particulate matter (PM2.5) have been drawing attention. However, information regarding the impact of low PM2.5 concentrations is limited. Hence, we aimed to investigate the short-term effects of the chemical components of PM2.5 on pulmonary function and their seasonal differences in healthy adolescents living on an isolated island without major artificial sources of air pollution. A panel study was repeatedly conducted twice a year for one month every spring and fall from October 2014 to November 2016 on an isolated island in the Seto Inland Sea, which has no major artificial sources of air pollution. Daily measurements of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) were performed in 47 healthy college students, and the concentrations of 35 chemical components of PM2.5 were analyzed every 24 h. Using a mixed-effects model, the relationship between pulmonary function values and concentrations of PM2.5 components was analyzed. Significant associations were observed between several PM2.5 components and decreased pulmonary function. Among the ionic components, sulfate was strongly related to decreases in PEF and FEV1 (-4.20 L/min [95 % confidence interval (CI): -6.40 to -2.00] and - 0.04 L [95 % CI: -0.05 to -0.02] per interquartile range increase, respectively). Among the elemental components, potassium induced the greatest reduction in PEF and FEV1. Therefore, PEF and FEV1 were significantly reduced as the concentrations of several PM2.5 components increased during fall, with minimal changes observed during spring. Several chemical components of PM2.5 were significantly associated with decreased pulmonary function among healthy adolescents. The concentrations of PM2.5 chemical components differed by season, suggesting the occurrence of distinct effects on the respiratory system depending on the type of component.

Stronger association between particulate air pollution and pulmonary function among healthy students in fall than in spring.

Previous studies have reported the short-term effects of particulate air pollution on health. However, most of those studies were relatively short in duration, with only a few, in healthy adolescents. We investigated the short-term effects of particulate air pollution on pulmonary function in healthy adolescents over a long period. A panel study was repeatedly conducted twice a year for about one month each, in spring and fall from 2014 to 2016, in an isolated island in the Seto Inland Sea, Japan. Daily measurements of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) were performed in a total of 48 healthy college students aged 15-19 years. The ambient concentrations of particulate matter with diameter ≤2.5 µm (PM2.5) and between 2.5 and 10 µm (PM10-2.5), and black carbon (BC) were continuously measured. A mixed-effects model was used to investigate the relationships between air pollutants and pulmonary function. In the overall analyses of the six study periods, decreases in the PEF and FEV1 were significantly associated with increases in the PM2.5 and BC concentrations. The greatest decrease was found in FEV1 (-1.97% [95% confidence interval (CI): -2.90, -1.04]), which was associated with an interquartile range (IQR) increase in the 0-72-h average concentrations of PM2.5 (14.1 µg/m3). Neither PEF nor FEV1 were associated with PM10-2.5 concentrations. In the analyses by season, both the PEF and FEV1 values decreased significantly in relation to increases in the PM2.5, PM10-2.5 and BC concentrations in the fall. However, in spring, both PEF and FEV1 showed weak associations with each of the pollutants. In conclusion, relatively low increases in the ambient particulate matter levels were associated with reduced pulmonary function among healthy adolescents. This association was stronger in fall than in spring.

Acute effects of air pollutants on pulmonary function among students: a panel study in an isolated island.

BACKGROUND: Many epidemiological studies on the health effects of air pollutants have been carried out in regions with major sources such as factories and automobiles. However, the health effects of air pollutants in regions without major sources remain unclear. This study investigated the acute effects of ambient air pollution on pulmonary function among healthy students in an isolated island without major artificial sources of air pollutants. METHODS: A panel study was conducted of 43 healthy subjects who attended a school in an isolated island in the Seto Inland Sea, Japan. We measured the forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF) every morning for about 1 month in May 2014. Ambient concentrations of particulate matter ≤ 2.5 µm in diameter (PM2.5), particulate matter between 2.5 and 10 µm in diameter (PM10-2.5), black carbon (BC), ozone (O3), and nitrogen dioxide (NO2) were measured. The associations between the concentrations of air pollutants and pulmonary function were analyzed using mixed-effects models. RESULTS: A decrease in FEV1 was significantly associated with BC concentrations (-27.28 mL [95%confidence interval (CI):-54.10,-0.46] for an interquartile range (IQR) increase of 0.23 µg/m3). The decrease in PEF was significantly associated with indoor O3 concentrations (-8.03 L/min [95% CI:-13.02,-3.03] for an IQR increase of 11 ppb). Among subjects with a history of allergy, an increase in PM2.5 concentrations was significantly associated with low FEV1. In subjects with a history of asthma, an inverse association between the indoor O3 concentration and pulmonary function was observed. CONCLUSIONS: Our results demonstrate that increases in BC and O3 concentrations have acute effects on the pulmonary function among students in an isolated island without major artificial sources of air pollutants.

Folliculotropic mycosis fungoides and a leonine clinical appearance of the face.

A 73-year-old man presented with a two year history of multiple nodules and follicular papules accompanied by slight itching on the face and the forearm. A physical examination showed multiple, soft, erythematous nodules on the forehead, cheek, and jaw, contributing to a generally leonine appearance of the face. Histopathological examination from the forehead revealed dense, massive concentrations of atypical lymphocytes in the dermis, and the forearm showed infiltration of atypical lymphocytes predominantly around the follicles. We diagnosed this condition as folliculotropic cutaneous T cell lymphoma (CTCL). EPOCH therapy was very effective and the lesions of the forehead and forearm showed a decrease in tumor elevation; the histology showed a precipitous decrease in the number of the atypical lymphocytes.