Cerebrospinal fluid distribution and pharmacokinetics of ponatinib in Ph1-positive acute lymphoblastic leukemia.

Tyrosine kinase inhibitors have improved outcomes in Philadelphia-positive ALL, but their efficacy in CNS disease remains uncertain. Ponatinib was studied for CNS distribution in 22 samples from 16 patients. CSF concentrations fell below the 40nM threshold, suggesting suboptimal CNS exposure.

Extreme events induced by collisions in a forced semiconductor laser.

We report on the experimental study of an optically driven multimode semiconductor laser with a 1 m cavity length. We observed a spatiotemporal regime where real-time measurements reveal very high-intensity peaks in the laser field. Such a regime, which coexists with the locked state and with stable phase solitons, is characterized by the emergence of extreme events that produce heavy tail statistics in the probability density function. We interpret the extreme events as collisions of spatiotemporal structures with opposite chirality. Numerical simulations of the semiconductor laser model, showing very similar dynamical behavior, substantiate our evidences and corroborate the description of interactions such as collisions between phase solitons and transient structures with different phase rotations.

Statistics of a turbulent Raman fiber laser.

We report the experimental study of statistical properties of partially coherent waves emitted by a Raman fiber laser operating in the normal dispersion regime. Using an asynchronous optical sampling technique, we accurately measure the probability density function of the optical power of the Stokes wave that exhibits strong and fast fluctuations. As predicted from numerical simulations presented by Randoux et al. [Opt. Lett.36, 790 (2011)], the statistical distributions of the intracavity Stokes power are found to be very different before and after reflection on the cavity Bragg mirrors. In particular, the Stokes wave incident on fiber Bragg grating mirrors exhibits statistics with tails that are much lower than those defined by the normal law.

Optical rogue waves in integrable turbulence.

We report optical experiments allowing us to investigate integrable turbulence in the focusing regime of the one-dimensional nonlinear Schrödinger equation (1D NLSE). In analogy with broad spectrum excitation of a one-dimensional water tank, we launch random initial waves in a single mode optical fiber. Using an original optical sampling setup, we measure precisely the probability density function of optical power of the partially coherent waves rapidly fluctuating with time. The probability density function is found to evolve from the normal law to a strong heavy-tailed distribution, thus revealing the formation of rogue waves in integrable turbulence. Numerical simulations of 1D NLSE with stochastic initial conditions quantitatively reproduce the experiments. Our numerical investigations suggest that the statistical features experimentally observed rely on the stochastic generation of coherent analytic solutions of 1D NLSE.

Intermittency in integrable turbulence.

We examine the statistical properties of nonlinear random waves that are ruled by the one-dimensional defocusing and integrable nonlinear Schrödinger equation. Using fast detection techniques in an optical fiber experiment, we observe that the probability density function of light fluctuations is characterized by tails that are lower than those predicted by a Gaussian distribution. Moreover, by applying a bandpass frequency optical filter, we reveal the phenomenon of intermittency; i.e., small scales are characterized by large heavy-tailed deviations from Gaussian statistics, while the large ones are almost Gaussian. These phenomena are very well described by numerical simulations of the one-dimensional nonlinear Schrödinger equation.

Transient buildup of the optical power spectrum in Raman fiber lasers.

We implement an experimental technique enabling to study the transient buildup of the optical power spectrum in a Raman fiber laser. We investigate the way through which the laser optical power spectrum broadens before reaching its shape at steady-state.