1.
Pol J Pharmacol Pharm
; 38(3): 309-19, 1986.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3490658
RESUMO
The synthesis of two Schiff bases of aryl methyl ketones and ethylenediamine 1c, 1d, symmetric adducts of aryl isothiocyanates with Schiff bases 2d-2m and 2-thioxopyrrolidine-4,5-dione derivatives 4d-4m obtained by condensation of oxalyl chloride with Schiff bases of aroylthioacetic acid anilides and ethylenediamine is described. Some of 13 investigated compounds 4a, 4b, 4d-4l, 5a, 5b of 2-thioxopyrrolidine-4,5-dione type showed sedative and analgesic action.
Assuntos
Analgésicos , Pirrolidinas/farmacologia , 5-Hidroxitriptofano/farmacologia , Analgésicos/síntese química , Analgésicos/toxicidade , Animais , Anticonvulsivantes , Interações Medicamentosas , Desamparo Aprendido , Dose Letal Mediana , Masculino , Camundongos , Atividade Motora/efeitos dos fármacos , Pirrolidinas/síntese química , Pirrolidinas/toxicidade , Ratos , Ratos Endogâmicos , Sono/efeitos dos fármacos , Comportamento Estereotipado/efeitos dos fármacos
2.
Pol J Pharmacol Pharm
; 34(5-6): 391-8, 1982.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6985305
RESUMO
New 2,3-dihydrofuran-2,3-dione derivatives (1-11) were obtained by condensation of oxalyl chloride with Schiff bases of acetyl- or benzoylacetone and aromatic amines. These compounds showed only weak sedative action and weak analgesic effect.
