Experimental Study on the Dielectric Properties of Coal In Situ with Variable Temperatures.

The aim of this study was to explore the mapping relationship between the temperature and the dielectric parameters of coal and rock under variable temperatures as well as to determine the characteristics of a dielectric anomaly response. Experiments were performed using lignite, nonstick coal, gas coal, coking coal, and anthracite. The evolution of pyrolysis characteristics, microcrystal structure, and dielectric properties with changing temperature was investigated, and the changes in the dielectric parameters of coal and rock were comprehensively analyzed. As such, the cause of the dielectric anomaly with changing temperatures of coal and rock was revealed. The results show that the dielectric properties of coal at different pyrolysis temperatures are closely related to the degree of intermolecular thermal motion, the evolution of microcrystal structure, and the mechanism of polarization response. In the low-temperature stage, the thermal motion of coal molecules is weak and exhibits electronic polarization, and the dielectric parameters change slightly with temperature while being dependent on the moisture content. In the high-temperature pyrolysis stage, the intense molecular thermal motion leads to the breaking of chemical bonds and the release of volatiles; moreover, the distance between aromatic layers of coal decreases, the order of aromatic structure increases, the dipole turning polarization is the main polarization type, and the dielectric response is obvious. When the pyrolysis reaction is basically complete, the dielectric constants of the five coal samples reach the maximum. As the temperature increases continuously, the coal structure is destroyed by the weakening of the thermal motion of the coal molecules and the accumulation of thermal stress; meanwhile, the dielectric constant decreases gradually, while the dielectric loss and tangent of dielectric loss increase rapidly. At the same temperature, the dielectric constant decreases with an increase in test frequency. These results lay a foundation for the inversion of dielectric data in fire areas of coal mines.

Non-targeted analysis and toxicity prediction for evaluation of photocatalytic membrane distillation removing organic contaminants from hypersaline oil and gas field-produced water.

Membrane distillation (MD) has received ample recognition for treating complex wastewater, including hypersaline oil and gas (O&G) produced water (PW). Rigorous water quality assessment is critical in evaluating PW treatment because PW consists of numerous contaminants beyond the targets listed in general discharge and reuse standards. This study evaluated a novel photocatalytic membrane distillation (PMD) process, with and without a UV light source, against a standard vacuum membrane distillation (VMD) process for treating PW, utilizing targeted analyses and a non-targeted chemical identification workflow coupled with toxicity predictions. PMD with UV light resulted in better removals of dissolved organic carbon, ammoniacal nitrogen, and conductivity. Targeted organic analyses identified only trace amounts of acetone and 2-butanone in distillates. According to non-targeted analysis, the number of suspects reduced from 65 in feed to 25-30 across all distillate samples. Certain physicochemical properties of compounds influenced contaminant rejection in different MD configurations. According to preliminary toxicity predictions, VMD, PMD with and without UV distillate samples, respectively contained 21, 22, and 23 suspects associated with critical toxicity concerns. Overall, non-targeted analysis together with toxicity prediction provides a competent supportive tool to assess treatment efficiency and potential impacts on public health and the environment during PW reuse.

Efficient and Selective Removal of Heavy Metals and Dyes from Aqueous Solutions Using Guipi Residue-Based Hydrogel.

The presence of organic dyes and heavy metal ions in water sources poses a significant threat to human health and the ecosystem. In this study, hydrogel adsorbents for water pollution remediation were synthesized using Guipi residue (GP), a cellulose material from Chinese herbal medicine, and chitosan (CTS) through radical polymerization with acrylamide (AM) and acrylic acid (AA). The characteristics of the hydrogels were analyzed from a physicochemical perspective, and their ability to adsorb was tested using model pollutants such as Pb2+, Cd2+, Rhodamine B (RhB), and methyl orange (MO). The outcomes revealed that GP/CTS/AA-co-AM, which has improved mechanical attributes, effectively eliminated these pollutants. At a pH of 4.0, a contact duration of 120 min, and an initial concentration of 600 mg/L for Pb2+ and 500 mg/L for Cd2+, the highest adsorption capabilities were 314.6 mg/g for Pb2+ and 289.1 mg/g for Cd2+. Regarding the dyes, the GP/CTS/AA-co-AM hydrogel displayed adsorption capacities of 106.4 mg/g for RhB and 94.8 mg/g for MO, maintaining a stable adsorption capacity at different pHs. Compared with other competitive pollutants, GP/CTS/AA-co-AM demonstrated a higher absorption capability, mainly targeted toward Pb2+. The adsorption processes for the pollutants conformed to pseudo-second-order kinetics models and adhered to the Langmuir models. Even after undergoing five consecutive adsorption and desorption cycles, the adsorption capacities for heavy metals and dyes remained above 70% and 80%. In summary, this study effectively suggested the potential of the innovative GP/CTS/AA-co-AM hydrogel as a practical and feasible approach for eliminating heavy metals and dyes from water solutions.

Multivariate classification based on large-scale brain networks during early abstinence predicted lapse among male detoxified alcohol-dependent patients.

Identifying biomarkers to predict lapse of alcohol-dependence (AD) is essential for treatment and prevention strategies, but remains remarkably challenging. With an aim to identify neuroimaging features for predicting AD lapse, 66 male AD patients during early-abstinence (baseline) after hospitalized detoxification underwent resting-state functional magnetic resonance imaging and were then followed-up for 6 months. The relevance-vector-machine (RVM) analysis on baseline large-scale brain networks yielded an elegant model for differentiating relapsing patients (n = 38) from abstainers, with the area under the curve of 0.912 and the accuracy by leave-one-out cross-validation of 0.833. This model captured key information about neuro-connectome biomarkers for predicting AD lapse.

High-Performance Hot-Exciton OLEDs via Fully Harvesting Triplet Excited States from Both the Exciplex Co-Host and the TBRb Emitter.

The high-level reverse intersystem crossing (HL-RISC, T2 → S1 ) process from triplet to singlet exciton, namely the "hot exciton" channel, has recently been demonstrated in the traditional fluorescent emitter of TBRb. Although it is a potential pathway to improve the utilization of non-radiative triplet exciton energy, highly efficient fluorescent organic light emitting diodes (FOLEDs) based on this "hot exciton" channel have not been developed. Herein, high-efficiency and low-efficiency roll-off FOLEDs are achieved through doping TBRb molecules into an energy-level matched exciplex co-host. Combining the low-level RISC (LL-RISC, EX3 → EX1 ) process in the exciplex co-host with the HL-RISC process of hot excitons in TBRb to fully harvest the triplet energy, a record-high external quantum efficiency (EQE) of 20.4% is obtained via a proper Dexter energy transfer of triplet excitons, realizing the efficiency breakthrough from fully fluorescent material-based OLEDs with TBRb as an end emitter. Furthermore, the fingerprint Magneto-electroluminescence (MEL) as a sensitive measuring tool is employed to visualize the "hot exciton" channel in TBRb, which also directly verifies the effective energy confinement and the full utilization of hot excitons. Obviously, this work paves a promising way for further fabricating high-efficiency TBRb-based FOLEDs for lighting and flat-panel display applications.

Efficient Removal of Heavy Metals from Aqueous Solution Using Licorice Residue-Based Hydrogel Adsorbent.

The removal of heavy metals through adsorption represents a highly promising method. This study focuses on the utilization of an abundant cellulose-rich solid waste, licorice residue (LR), as a natural material for hydrogel synthesis. To this end, LR-EPI hydrogels, namely, LR-EPI-5, LR-EPI-6 and LR-EPI-8, were developed by crosslinking LR with epichlorohydrin (EPI), specifically targeting the removal of Pb, Cu, and Cr from aqueous solutions. Thorough characterizations employing Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy confirmed the successful crosslinking of LR-EPIs by EPI, resulting in the formation of porous and loosely structured hydrogels. Batch studies demonstrated the high efficacy of LR-EPI hydrogels in removing the three heavy metal ions from aqueous solutions. Notably, LR-EPI-8 exhibited the highest adsorption capacity, with maximum capacities of 591.8 mg/g, 458.3 mg/g, and 121.4 mg/g for Pb2+, Cr3+, and Cu2+, respectively. The adsorption processes for Pb2+ and Cu2+ were well described by pseudo-second-order kinetics and the Langmuir model. The adsorption mechanism of LR-EPI-8 onto heavy metal ions was found to involve a combination of ion-exchange and electrostatic interactions, as inferred from the results obtained through X-ray photoelectron spectroscopy and FTIR. This research establishes LR-EPI-8 as a promising adsorbent for the effective removal of heavy metal ions from aqueous solutions, offering an eco-friendly approach for heavy metal removal and providing an environmentally sustainable method for the reutilization of Chinese herb residues. It contributes to the goal of "from waste, treats waste" while also addressing the broader need for heavy metal remediation.

Generation and Characterization of a Replication-Competent Human Adenovirus Type 55 Encoding EGFP.

Human adenovirus 55 (HAdV-55) has recently caused outbreaks of acute respiratory disease (ARD), posing a significant public threat to civilians and military trainees. Efforts to develop antiviral inhibitors and quantify neutralizing antibodies require an experimental system to rapidly monitor viral infections, which can be achieved through the use of a plasmid that can produce an infectious virus. Here, we used a bacteria-mediated recombination approach to construct a full-length infectious cDNA clone, pAd55-FL, containing the whole genome of HadV-55. Then, the green fluorescent protein expression cassette was assembled into pAd55-FL to replace the E3 region to obtain a recombinant plasmid of pAd55-dE3-EGFP. The rescued recombinant virus rAdv55-dE3-EGFP is genetically stable and replicates similarly to the wild-type virus in cell culture. The virus rAdv55-dE3-EGFP can be used to quantify neutralizing antibody activity in sera samples, producing results in concordance with the cytopathic effect (CPE)-based microneutralization assay. Using an rAdv55-dE3-EGFP infection of A549 cells, we showed that the assay could be used for antiviral screening. Our findings suggest that the rAdv55-dE3-EGFP-based high-throughput assay provides a reliable tool for rapid neutralization testing and antiviral screening for HAdV-55.

Misdiagnosis of a Patient with Hepatic Alveolar Echinococcosis with Hepatapostema: A Case Report.

Alveolar echinococcosis (AE) is an important zoonotic tropical disease in China that affects people living in western endemic areas. The disease is prone to occur in the liver with a characteristic similar to slow-growing malignant tumors. We report a 31-year-old male patient with serious complication after hepatorrhaphy, who had presented with clinical manifestations of hepatapostema with infection. Ultrasound (US) and computer tomography (CT) are two important medical imaging modalities to diagnose hepatic AE. Based on the medical history, clinical findings, laboratorial and imaging results, the patient was misdiagnosed with hepatapostema. A series of subsequent treatments were ineffective. Finally, partial hepatectomy was performed, and postoperative pathological results confirmed hepatic AE. The patient has now recovered.

Emotional distress and multimorbidity patterns in Chinese Han patients with osteoporosis: a network analysis.

With the aging of the population, the prevalence of osteoporosis and multimorbidity is increasing. Patients with osteoporosis often experience varying levels of emotional distress, including anxiety and depression. However, few studies have explored the patterns of multiple conditions and their impact on patients' emotional distress. Here, we conducted a network analysis to explore the patterns of multimorbidities and their impact on emotional distress in 13,359 Chinese Han patients with osteoporosis. The results showed that multimorbidity was prevalent in Chinese patients with osteoporosis and increased with age, and was more frequent in males than in females, with the most common pattern of multimorbidity being osteoporosis and essential (primary) hypertension. Finally, we found that patients' emotional distress increased with the number of multimorbidities, especially in female patients, and identified eight multimorbidities with high correlation to patients' emotional distress.

Automated Digital Interventions and Smoking Cessation: Systematic Review and Meta-analysis Relating Efficiency to a Psychological Theory of Intervention Perspective.

BACKGROUND: Smoking remains a highly significant preventable global public health problem. In this context, digital interventions offer great advantages in terms of a lack of biological side effects, possibility of automatic delivery, and consequent human resource savings relative to traditional interventions. Such interventions have been studied in randomized controlled trials (RCTs) but have not been systematically reviewed with the inclusion of text-based and multiplatform-based interventions. In addition, this area has not been evaluated from the perspective of the psychological theoretical basis of intervention. OBJECTIVE: The aim of this paper is to assess the efficiency of digital interventions in RCT studies of smoking cessation and to evaluate the effectiveness of the strategies used for digital interventions. METHODS: An electronic search of RCTs was conducted using PubMed, Embase, and the Cochrane Library by June 30, 2021. Eligible studies had to compare automated digital intervention (ADI) to the use of a self-help guideline or no intervention. Participants were current smokers (aged 16 years or older). As the main outcome, abstinence after endpoint was extracted from the studies. Systematic review and meta-analysis were conducted to assess the efficiency of ADIs. Metaregressions were conducted to assess the relationship between intervention theory and effectiveness. RESULTS: A total of 19 trials (15,472 participants) were included in the analysis. The overall abstinence rate (95% CI) at the endpoint was 17.8% (17.0-18.7). The overall risk ratio of the intervention group compared to the controls at the endpoint was 17.8% (17.0-18.7). Cochrane risk-of-bias tool for randomized trials (ROB 2) suggested that most of the studies had a low risk of bias (56.3%). Psychological theory-related constructs or predictors, which refer to other theory-based concepts (rather than only behavioral theory) such as craving or anxiety, are associated with effectiveness. CONCLUSIONS: This study found that ADI had a clear positive effect compared to self-help guidelines or to no intervention, and effectiveness was associated with theory-related constructs or predictors. ADIs should be promoted by policy makers and clinical practitioners to address the huge gap between the need for smoking cessation and availability of traditional treatment resources. Possible increases in ADI efficiency may be achieved by optimally integrating psychotherapeutic theories and techniques. TRIAL REGISTRATION: PROSPERO CRD42021256593; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=256593.

Case report: Chronological symptom profile after cessation of overdose zolpidem in a patient with comorbid bipolar disorder-from anxiety, craving, paresthesia and influenza-like symptoms to seizures and hallucinations.

Introduction: Insomnia is a major public health problem that determines the quality of life. Among the many causes of insomnia, psychological factors have an important influence on the process, duration of insomnia, help-seeking behavior, and treatment choice. Regarding medical treatment, zolpidem is always chosen to treat acute and transient insomnia due to its few side effects. Although some randomized controlled trials have verified its safety, zolpidem abuse and withdrawal reactions have been reported in recent years. Case report: A 25-year-old unmarried man with a college degree who worked as a graphic designer was referred and admitted to the inpatient ward for a chief complaint of "alternative episodes of lowering and elevation of mood for 10 years, overdosage use of zolpidem for two years." He underwent a time-dependent withdrawal reaction after admission. It was characterized by rebound insomnia, anxiety, craving, skin paresthesia, influenza-like symptoms, tonic-clonic-type seizures, and hallucinations. At the 1-year follow-up, he did not exhibit any remaining withdrawal symptoms. Discussion: The acute cessation of overdosage zolpidem use causes a series of withdrawal symptoms that manifest in chronological order. Additionally, long-term benzodiazepine exposure has potential influences on zolpidem dependence/tolerance. However, patients with a history of abuse or dependence, or mental disorders seem to be at risk of drug abuse. Clinicians should be alert to the potential for zolpidem dependence and addiction. Once the acute cessation of overdosage zolpidem use occurs, the potential of the withdrawal reaction needs to be considered and addressed properly.

Datasets associated with the characterization of produced water and Pecos River water in the Permian Basin, the United States.

The data in this report are associated with "Characterization of Produced Water and Surrounding Surface Water in the Permian Basin, the United States" (Jiang et al. 2022) and include raw data on produced water (PW) quality and Pecos River water quality in the Permian Basin, which is one of the major oil and gas producing areas in the U.S. The data include 46 samples for PW and 10 samples for Pecos River water. The data include wet chemistry, mineral salts, metals, oil and grease, volatile and semi-volatile organic compounds, radionuclides, ammonia, hydraulic fracturing additives, and per- and polyfluoroalkyl substances. The PW samples were collected from five different locations in the Permian Basin. Twenty-four of the PW samples and the ten Pecos River samples were analyzed by the authors. The information for the rest of PW samples (22 samples) was provided by industrial collaborators in the Permian Basin. Statistical analyses were performed on the combined data to obtain Mean, Max, Min, 25th percentile, 50th percentile, and 75th percentile of each analyte.

Effects of Stress in Adaptation to Undergraduate Life on Psychiatric Morbidity: Mediating Effects of Early Trauma and Adverse Family Factors.

Purpose: University students experience high levels of stress, and the prevalence of depression is higher than in the general population. The reason is not clear. More effective interventions and better prevention are needed. Methods: We did annual cross-sectional surveys of Chinese undergraduates 2014-2018 (mean age 18.7 [SD 2.1], N = 39,573). We measured adaptation to university life using the Adolescent Self-rating Life Events Checklist (ASLEC) and common mental disorders using standardized self-report instruments. Regression analyses identified associations between childhood maltreatment, current family problems, stress in adaptation to undergraduate life, and psychiatric morbidity. Mediation analyses further tested relationships between these factors. Results: Childhood maltreatment, current family problems, stress in adaptation, and psychiatric morbidity were all significantly associated with each other. The strongest association between childhood experiences and psychiatric morbidity was for sexual abuse and depression (OR = 3.39, 95%CI: 2.38-4.83, p < 0.001) and between stress from adaptation and somatic disorder (OR = 4.54, 95%CI: 3.62-5.68, p < 0.001). Associations between childhood maltreatment and stress from university life were partly mediated by psychiatric morbidity. Associations between family problems and psychiatric morbidity were mediated by stress from university life. Conclusions: Stress from adaptation to university life and pressures from academic study exert stronger effects on psychiatric morbidity among students than childhood traumatic experiences and current family problems, although these factors are closely interrelated. Mental health services for students should focus on adaptation to university life and pressures from academic study as well as external factors of childhood trauma and family problems.

Characterization of produced water and surrounding surface water in the Permian Basin, the United States.

A thorough understanding of produced water (PW) quality is critical to advance the knowledge and tools for effective PW management, treatment, risk assessment, and feasibility for beneficial reuse outside the oil and gas industry. This study provides the first step to better understand PW quality to develop beneficial reuse programs that are protective of human health and the environment. In total, 46 PW samples from unconventional operations in the Permian Basin and ten surface water samples from the Pecos River in New Mexico were collected for quantitative target analyses of more than 300 constituents. Water quality analyses of Pecos River samples could provide context and baseline information for the potential discharge and reuse of treated PW in this area. Temporal PW and river water quality changes were monitored for eight months in 2020. PW samples had total dissolved solids (TDS) concentrations ranging from 100,800-201,500 mg/L. Various mineral salts, metals, oil and grease, volatile and semi-volatile organic compounds, radionuclides, ammonia, hydraulic fracturing additives, and per- and polyfluoroalkyl substances were detected at different concentrations. Chemical characterization of organic compounds found in Pecos River water showed no evidence of PW origin. Isometric log-ratio Na-Cl-Br analysis showed the salinity in the Pecos River samples appeared to be linked to an increase in natural shallow brine inputs. This study outlines baseline analytical information to advance PW research by describing PW and surrounding surface water quality in the Permian Basin that will assist in determining management strategies, treatment methods, potential beneficial reuse applications, and potential environmental impacts specific to intended beneficial use of treated PW.

Generation and characterization of human-derived iPSC lines from one pair of dizygotic twins discordant for schizophrenia.

Schizophrenia (SCZ) is a debilitating neurodevelopmental disorder with a high heritability. In this study, peripheral blood mononuclear cells (PBMCs) were donated by a pair of dizygotic twins. The female was clinically diagnosed as SCZ by Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) criteria, and her unaffected male sibling was healthy control. Induced pluripotent stem cells (iPSCs) were established using Episomal vectors carrying reprograming factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT. These lines with normal karyotype highly expressed pluripotency markers and are capable to differentiate into derivatives of three germ layers. Both lines are negative of mycoplasma.

Data-driven study on resting-state functional magnetic resonance imaging during early abstinence of alcohol dependence in male patients and its predictive value for relapse.

BACKGROUND: Alcohol dependence is a mental disorder with a high relapse rate. However, specific neuroimaging biomarkers have not been determined for alcohol dependence and its relapse. We conducted data-driven research to investigate resting-state functional magnetic resonance imaging (rs-fMRI) during early abstinence from alcohol dependence and its potential ability to predict relapse. METHODS: Participants included 68 alcohol-dependent patients and 68 healthy controls (HCs). The regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) were compared between the alcohol dependence group and the HCs and between the relapse group and the nonrelapse group. The brain regions that presented significantly different ReHo and/or fALFF between the alcohol-dependent patients and HCs and/or between the relapsed and nonrelapsed patients were selected as the seeds to calculate the functional connectivities (FCs). RESULTS: During a 6-month follow-up period, 52.24% of alcohol-dependent patients relapsed. A regression model for differentiating alcohol-dependent patients and HCs showed that reductions in ReHo in the left postcentral region, fALFF in the right fusiform region, and FC in the right fusiform region to the right middle cingulum were independently associated with alcohol dependence, with an area under the receiver operating characteristic curve (AUC) of 0.841. The baseline FC of the left precentral to the left cerebellum of the relapse group was significantly lower than that of the nonrelapse group. The AUC of this FC to predict relapse was 0.774. CONCLUSIONS: Our findings contribute to advancing research on the neurobiological etiology and predictive biomarkers for relapse associated with alcohol dependence.

Toxicological characterization of produced water from the Permian Basin.

Produced water (PW) is a hypersaline waste stream generated from the shale oil and gas industry, consisting of numerous anthropogenic and geogenic compounds. Despite prior geochemical characterization, the comprehensive toxicity assessment is lacking for evaluating treatment technologies and the beneficial use of PW. In this study, a suite of in vitro toxicity assays using various aquatic organisms (luminescent bacterium Vibrio fischeri, fish gill cell line RTgill-W1, and microalgae Scenedesmus obliquus) were developed to investigate the toxicological characterizations of PW from the Permian Basin. The exposure to PW, PW inorganic fraction (PW-IF), and PW salt control (PW-SC) at 30-50% dilutions caused significant toxicological effects in all model species, revealing the high salinity was the foremost toxicological driver in PW. In addition, the toxicity level of PW was usually higher than that of PW-IF, suggesting that organic contaminants might also play a critical role in PW toxicity. When comparing the observed toxicity with associated chemical characterizations in different PW samples, strong correlations were found between them since higher concentrations of contaminants could generally result in higher toxicity towards exposed organisms. Furthermore, the toxicity results from the pretreated PW indicated that those in vitro toxicity assays had different sensitives to the chemical components present in PW. As expected, the combination of multiple pretreatments could lead to a more significant decrease in toxicity compared to the single pretreatment since the mixture of contaminants in PW might exhibit synergistic toxicity. Overall, the current work is expected to enhance our understanding of the potential toxicological impacts of PW to aquatic ecosystems and the relationships between the chemical profiles and observed toxicity in PW, which might be conducive to the establishment of monitoring, remediation, treatment, and reuse protocols for PW.

A bidirectional association between internet addiction and depression: A large-sample longitudinal study among Chinese university students.

BACKGROUND: Internet addiction (IA) is associated with adverse consequences, especially for younger people. Evidence indicates that IA is associated with depression, but no studies have yet investigated potential common vulnerability between them. METHODS: IA (measured by the Young's 20-item Internet Addiction Test Scale) and depressive symptoms (measured by the Patient Health Questionnaire-9 Scale) among 12 043 undergraduates were surveyed at baseline and at a respective 12 month follow-up for each participant. Application of a cross-lagged panel model approach (CLPM) revealed an association between IA and depression after adjusting for demographic variables. RESULTS: Rates of baseline IA and depression were 5.47% (95% CI: 5.07%, 5.88%) and 3.85% (95% CI: 3.51%, 4.20%), respectively; increasing to 9.47% (95% CI: 8.94%, 9.99%) and 5.58% (95% CI: 5.17%,5.99%), respectively, at follow-up. Rates of new-incidences of IA and depression over 12 months were 7.43% (95% CI: 6.95%, 7.91%) and 4.47% (95% CI: 4.09%, 4.84%), respectively. Models in the present analysis revealed that baseline depression had a significant net-predictive effect on follow-up IA, and baseline IA had a significant net-predictive effect on follow-up depression. LIMITATIONS: The follow-up survey response rate was moderate (54.69%) in this analysis of university students. Moreover, the IAT-20 scale did not allow differentiate between specific forms of Internet activity. CONCLUSIONS: Common vulnerability and bidirectional cross-causal effects may both contribute to the association between IA and depression, with common vulnerability likely playing a more significant role than cross-causal effects.

Photocatalytic membrane reactors for produced water treatment and reuse: Fundamentals, affecting factors, rational design, and evaluation metrics.

Treatment and reuse of produced water (PW), the largest wastewater stream generated during oil and gas production, provides a promising option to address the increasing clean water demands. High-performance treatment technologies are needed to efficiently remove the organic and inorganic contaminants in PW for fit-for-purpose applications. Photocatalytic membrane reactor (PMR) is an emerging green technology for removal of organic pollutants, photoreduction of heavy metals, photo-inactivation of bacteria, and resource recovery. This study critically reviewed the mechanisms of photocatalysis and membrane processes in PMR, factors affecting PMR performance, rational design, and evaluation metrics for PW treatment. Specifically, PW characteristics, photocatalysts properties, membranes applied, and operating conditions are of utmost importance for rational design and reliable operation of PMR. PW pretreatment to remove oil and grease, colloidal and suspended solids is necessary to reduce membrane fouling and ensure optimal PMR performance. The metrics to evaluate PMR performance were developed including light utilization, exergetic efficiency, water recovery, product water improvement, lifetime of the photocatalyst, and costs. This review also presented the research gaps and outlook for future research.

Testing extra-linearity across a psychosis continuum.

BACKGROUND: It is unclear whether psychotic experiences (PEs) gradually merge into states of clinical psychosis along a continuum which correspond to a dimensional classification or whether latent classes appear above a certain severity threshold which correspond better to diagnostic categories of psychosis. METHODS: Annual cross-sectional surveys, 2014-19, among Chinese undergraduates (N = 47,004) measured PEs, depression and etiological risk factors using standardized self-report instruments. We created a psychosis continuum with five levels and tested linear and extra-linear contrasts in associated etiological risk factors, before and after adjustment for depression. We carried out latent class analysis. RESULTS: Categorical expression of psychosis, including hallucinations and delusions, nuclear symptoms, and nuclear symptoms and depression were found at severe level 5. Etiological risk factors which impacted linearly across the continuum were more common for depression. Child maltreatment impacted extra-linearly on both psychosis and depression. Family history of psychosis impacted linearly on psychosis; male sex and urban birth impacted extra-linearly and were specific for psychosis. Four latent classes were found, but only at level 5. These corresponded to nuclear schizophrenia symptoms, nuclear schizophrenia and depressive symptoms, severe depression, and an unclassified category with moderate prevalence of PEs. CONCLUSION: Quantitative and qualitative changes in the underlying structure of psychosis were observed at the most severe level along a psychosis continuum, where four latent classes emerged. These corresponded to existing categorical classifications but require confirmation with clinical interview. PEs are non-specific and our findings suggest some are on a continuum with depression, whilst others are on a continuum with non-affective psychosis. Differing patterns of impact from etiological risk factors across the spectrum of psychopathology determine outcome at the most severe level of these continua.