1.
Bioorg Med Chem Lett
; 12(23): 3425-9, 2002 Dec 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12419376
RESUMO
Structure-based design has led to the synthesis of a novel analogue of GS-4071, an influenza neuraminidase inhibitor, in which the basic amino group has been replaced by a hydrophobic vinyl group. An X-ray co-crystal structure of the new inhibitor (K(i)=45 nM) bound to the active site shows that the vinyl group occupies the same subsite as the amino group in GS-4071.