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1.
J Org Chem ; 84(16): 10554-10558, 2019 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-31353913

RESUMO

A synthetic pathway to a functionalized tetrahydro[5]phenacene was developed, which served as a precursor, leading to a dehydrobenzo[32]annulene macrocycle containing four carbon-carbon triple bonds. The high efficiency of the macrocyclization step can be attributed to the structural rigidity of its immediate precursor. Hydrogenation of the four carbon-carbon triple bonds produced a macrocycle bearing a carbon framework of [16]cyclophenacene as the shortest macrocyclic belt-like structure of an (8,8)armchair carbon nanotube.

2.
J Org Chem ; 83(4): 2455-2459, 2018 02 16.
Artigo em Inglês | MEDLINE | ID: mdl-29377690

RESUMO

A synthetic pathway to a cyclophane bearing two benz[a]anthracene units connected at the 5 and 7 positions through two naphth-1,4-diyl groups was developed, and its structure was confirmed by X-ray structure analysis. Because of structural constraints, the two naphthyl groups are distorted from planarity and the bonds connecting them to the benz[a]anthracene units are bent significantly. The UV-vis and fluorescence spectra of the cyclophane are red-shifted from those of 7-(1-naphthalenyl)benz[a]anthracene, which is the corresponding monomeric polycyclic aromatic hydrocarbon.

3.
J Org Chem ; 83(3): 1216-1222, 2018 02 02.
Artigo em Inglês | MEDLINE | ID: mdl-29308641

RESUMO

A synthetic pathway to a molecule bearing two molecular nanohoops, including a tetrahydro[6]cycloparaphenylene (4H[6]CPP) fused through two 1,4-dimethoxybenzene units to a 4H[10]CPP, was developed. Similarly, a molecule containing a 4H[6]CPP fused through two 1,4-dimethoxybenzene units to a molecular nanohoop bearing a [6]CPP inserted with two 2,2'-bithiophene-5,5'-diyl groups was synthesized. The Diels-Alder reactions of two (E,E)-1,4-diaryl-1,3-butadienes with 1,4-benzoquinone and the Ni-mediated homocoupling reactions are the key steps for the construction of macrocyclic ring structures. Oxidative aromatization with DDQ converted a hydrogenated system to a fully aromatized nanohoop with 10 aromatic units, including a [6]CPP inserted with two 2,2'-bithiophene-5,5'-diyl groups. The UV-vis and fluorescence spectra of the fused two-hoop systems were investigated.

4.
Org Lett ; 19(15): 4078-4081, 2017 08 04.
Artigo em Inglês | MEDLINE | ID: mdl-28727459

RESUMO

A synthetic pathway to a functionalized [9]cycloparaphenylene bearing three indeno[2,1-a]fluorene-11,12-dione-2,9-diyl units in the macrocyclic ring structure ([3]CIFO) has been developed. The 1H and 13C NMR spectra show that only the anti rotamer (anti-[3]CIFO) is produced. DFT calculations indicate that the anti rotamer is thermodynamically more stable than the syn rotamer by 4.3 kcal/mol, and the rotational barrier from the anti to syn rotamer is estimated to be 23.3 kcal/mol. The UV-vis and fluorescence spectra and cyclic voltammogram of anti-[3]CIFO were investigated.

5.
Org Lett ; 19(10): 2674-2677, 2017 05 19.
Artigo em Inglês | MEDLINE | ID: mdl-28492330

RESUMO

Synthetic pathways to conjugated macrocycles containing one, two, or three 2,7-bis(2-thienyl)-9H-fluoren-9-one (TFOT) units in the macrocyclic frameworks bearing 10, 16, or 24 aromatic units were developed. The Diels-Alder reaction between (E,E)-1-(5-bromo-2-thienyl)-4-(5-iodo-2-thienyl)-1,3-butadiene and dimethyl acetylenedicarboxylate produced the key Diels-Alder adduct for the subsequent macrocyclic ring formation. UV-vis and fluorescence spectra of the TFOT-containing molecules were recorded, and their electrochemical properties were investigated by cyclic and differential pulse voltammetry. Solvatofluorochromic properties were observed for the TFOT-containing molecules.

6.
J Org Chem ; 82(8): 4458-4464, 2017 04 21.
Artigo em Inglês | MEDLINE | ID: mdl-28357851

RESUMO

Functionalized [12]cycloparaphenylenes ([12]CPPs) containing four alternating biphenyl and naphthyl units were synthesized. A macrocyclic furan-containing CPP precursor was used for the Diels-Alder reaction with the parent benzyne or 3,6-dimethoxybenzyne to form the corresponding macrocyclic carbon frameworks. The subsequent reductive deoxygenation of the Diels-Alder adducts with Fe2(CO)9 followed by oxidative aromatization with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone produced the functionalized [12]CPPs. The effect of macrocyclic ring size on the reaction rate of oxidative aromatization was investigated.

7.
J Org Chem ; 82(2): 1166-1174, 2017 01 20.
Artigo em Inglês | MEDLINE | ID: mdl-28006099

RESUMO

The Diels-Alder reactions between 2 equiv of (E,E)-1,4-bis(4-bromophenyl)-1,3-butadiene and 1,4-benzoquinone led to the formation of a key intermediate with all four 4-bromophenyl substituents cis to one another. The subsequent nickel-mediated homocoupling reactions then produced partially hydrogenated cycloparaphenylenes, including a molecule bearing two units of tetrahydro[6]cycloparaphenylene (4H[6]CPP) fused together through two 1,4-dimethoxybenzene units in an armchair (6,6)carbon nanotube-like connection. Similarly, two 6H[9]CPPs were connected through three 1,4-dimethoxybenzene units in an armchair (9,9)carbon nanotube-like arrangement. A bent 8H[12]CPP and a bent 12H[18]CPP, which were fused intramolecularly with two and three 1,4-dimethoxybenzene units, respectively, to create the bent structures, were likewise synthesized. A molecule containing a bent 8H[12]CPP fused to a 4H[6]CPP was likewise constructed. The structures of these partially hydrogenated CPPs were established by X-ray structure analysis, NMR spectroscopy, and additional independent synthetic pathways.

8.
Chemistry ; 22(46): 16420-16424, 2016 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-27607838

RESUMO

Synthetic pathways to furan-containing cycloparaphenylenes (CPPs) as molecular nanohoops bearing 10, 12, and 15 aromatic units including furan-2,5-diyl or 2,2'-bifuran-5,5'-diyl units have been developed. The X-ray structures of a partially hydrogenated bifuran-containing CPP precursor and the corresponding fully aromatized bifuran-containing CPP were obtained to allow the determination of their conformational arrangements in the crystal lattice. The optical and electrochemical properties of the furan-containing CPPs were investigated.

9.
Org Lett ; 18(9): 2268-71, 2016 05 06.
Artigo em Inglês | MEDLINE | ID: mdl-27101316

RESUMO

Functionalized [9]cycloparaphenylenes ([9]CPPs) bearing nine aromatic units in the macrocyclic structures were synthesized. The macrocyclic structures were substituted with carbomethoxy or N-phenylphthalimido groups. The Diels-Alder reaction of (E,E)-1,4-bis(4-bromophenyl)-1,3-butadiene or a related diene with dimethyl acetylenedicarboxylate followed by the nickel-mediated homocoupling reactions and oxidative aromatization produced the functionalized [9]CPPs. Treatment of a resultant [9]CPP with aniline or 1,4-diaminobenzene gave the corresponding N-phenylphthalimides. The X-ray structure of a [9]CPP bearing six carbomethoxy groups was obtained.

10.
Org Lett ; 17(14): 3470-3, 2015 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-26135911

RESUMO

Thiophene-containing cycloparaphenylenes (CPPs) bearing 8, 10, and 16 aromatic and heteroaromatic units in the macrocyclic ring structures were synthesized. Specifically, two and four thiophene-2,5-diyl units were incorporated into functionalized [6]- and [12]CPP macrocyclic carbon frameworks, respectively. In addition, two 2,2'-bithiophene-5,5'-diyl units were inserted into a functionalized [6]CPP carbon framework. The cyclic and differential pulse voltammetry and the UV-vis and fluorescence spectra of the fully aromatized macrocycles and their precursors exhibited interesting electrochemical and optical properties.


Assuntos
Carbono/química , Compostos Macrocíclicos/síntese química , Tiofenos/química , Cristalografia por Raios X , Eletroquímica , Compostos Macrocíclicos/química , Modelos Moleculares , Estrutura Molecular , Nanoestruturas/química , Espectrometria de Fluorescência , Raios Ultravioleta
11.
Chemosphere ; 131: 217-24, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25542639

RESUMO

A heated purge-and-trap gas chromatography/mass spectrometry method was used to determine the cis- and trans-isomers of (4-methylcyclohexyl)methanol (4-MCHM), the reported major component of the Crude MCHM/Dowanol™ PPh glycol ether material spilled into the Elk River upriver from Charleston, West Virginia, on January 9, 2014. The trans-isomer eluted first and method detection limits were 0.16-µg L(-1)trans-, 0.28-µg L(-1)cis-, and 0.4-µg L(-1) Total (total response of isomers) 4-MCHM. Estimated concentrations in the spill source material were 491-g L(-1)trans- and 277-g L(-1)cis-4-MCHM, the sum constituting 84% of the source material assuming its density equaled 4-MCHM. Elk River samples collected⩽3.2 km downriver from the spill on January 15 had low (⩽2.9 µg L(-1) Total) 4-MCHM concentrations, whereas the isomers were not detected in samples collected 2 d earlier at the same sites. Similar 4-MCHM concentrations (range 4.2-5.5 µg L(-1) Total) occurred for samples of the Ohio River at Louisville, Kentucky, on January 17, ∼630 km downriver from the spill. Total 4-MCHM concentrations in Charleston, WV, office tap water decreased from 129 µg L(-1) on January 27 to 2.2 µg L(-1) on February 3, but remained detectable in tap samples through final collection on February 25 indicating some persistence of 4-MCHM within the water distribution system. One isomer of methyl 4-methylcyclohexanecarboxylate was detected in all Ohio River and tap water samples, and both isomers were detected in the source material spilled.


Assuntos
Cromatografia Gasosa-Espectrometria de Massas/métodos , Metanol/química , Poluentes Químicos da Água/análise , Isomerismo , Rios/química , West Virginia
12.
Org Lett ; 16(10): 2672-5, 2014 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-24785776

RESUMO

A functionalized [9]cycloparaphenylene ([9]CPP) bearing three evenly spaced 5,8-dimethoxynaphth-1,4-diyl units and two macrocyclic [6]CPP precursors have been synthesized. The Diels-Alder reaction between (E,E)-1,4-bis(4-bromophenyl)-1,3-butadiene and 1,4-benzoquinone followed by methylation produces cis-5,8-bis(4-bromophenyl)-5,8-dihydro-1,4-dimethoxynaphthalene as the key intermediate for the construction of the hooplike structures. The nickel-mediated homocoupling reactions followed by aromatization led to the functionalized [9]CPP.

13.
Top Curr Chem ; 349: 31-61, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-22955509

RESUMO

The nonbonded steric interactions of substituents at the crowded C4 and C5 positions of phenanthrene cause the aromatic system to twist out of planarity. Similarly, the presence of substituents at the C1 and C12 positions of benzo[c]phenanthrene and at the C1 and C14 positions of dibenzo[c,g]phenanthrene are responsible for the helical twists of the aromatic frameworks. Highly substituted acenes, such as octamethylnaphthalene and decaphenylanthracene, also exhibit substantial end-to-end twists. The X-ray structures of these compounds allow direct measurements of the extent of the structural distortions. The configurational stabilities of many twisted arenes have also been determined.

14.
Beilstein J Org Chem ; 7: 496-502, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21647260

RESUMO

5-(2-Methoxy-1-naphthyl)- and 5-[2-(methoxymethyl)-1-naphthyl]-11H-benzo[b]fluorene were synthesized by treatment of the corresponding benzannulated enediynes with potassium tert-butoxide in refluxing toluene to give benzannulated enyne-allenes for the subsequent Schmittel cascade cyclization reactions. The structures of these two 5-(1-naphthyl)-11H-benzo[b]fluorenes could be regarded as 2,2'-disubstituted 1,1'-binaphthyls with the newly constructed benzofluorenyl group serving as a naphthyl moiety.

15.
Org Lett ; 13(1): 168-71, 2011 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-21128652

RESUMO

Treatment of benzannulated enediynyl alcohols with trifluoroacetic acid at room temperature promoted a cascade sequence of cyclization reactions, leading to 1,4-naphthoquinone methides. The transformation involved an unusual two-carbon ring expansion from the cyclic alcohols and the construction of the p-quinone methide ring from an acyclic system along the reaction pathway.


Assuntos
Ácidos/química , Álcoois/química , Benzeno/química , Enedi-Inos/química , Indolquinonas/síntese química , Naftoquinonas/química , Catálise , Ciclização , Modelos Moleculares , Estrutura Molecular
16.
Chem Commun (Camb) ; 46(11): 1938-40, 2010 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-20198259

RESUMO

Three 4,5-diheteroarylphenanthrenes 2a, 2b and 2c and two dinuclear Ru(ii) bis(terpyridine) complexes 13 and 14 possessing severe helical twists were synthesized.

17.
J Org Chem ; 75(6): 2050-6, 2010 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-20180580

RESUMO

A basket-shaped C(56)H(38) hydrocarbon (3) possessing a 30-carbon difluorenonaphthacenyl core that can be mapped onto the surface of C(78) was synthesized from 4-bromo-1-indanone. The first stage of the synthesis involved the preparation of tetraketone 10 as a key intermediate. The use of cascade cyclization reactions of benzannulated enyne-allenes as key features in the next stage of the synthetic sequence provides an efficient route to 3 from 4-bromo-1-indanone in 12 steps. The all-cis relationship among the methyl groups and the methine hydrogens causes the two benzofluorenyl units in 3 to be in an essentially perpendicular orientation to each other. Hydrocarbon 3 and its derivatives could serve as attractive precursors leading to a geodesic C(68)H(26) end-cap template for carbon [6,6]nanotubes.

18.
Org Lett ; 11(12): 2527-30, 2009 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-19462942

RESUMO

A C(56)H(40) hydrocarbon possessing a 54-carbon framework represented on the surface of C(60) was synthesized by solution-phase chemistry. The structure of this hydrocarbon has a 30-carbon core, which can be regarded as a partially hydrogenated [5,5]circulene, a C(30)H(12) semibuckminsterfullerene, with only one of the carbon-carbon bonds remaining unconnected. The central 30-carbon core is fused with two indeno groups and bears two phenyl and two methyl substituents.

19.
Chemphyschem ; 9(2): 293-9, 2008 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-18219647

RESUMO

A four fused-ring system 11-propyl-6H-indolo[2,3-b]quinoline (6 HIQ) is strategically designed and synthesized; it possesses a central moiety of 7-azaindole (7AI) and undergoes excited-state double proton transfer (ESDPT). Despite a barrierless type of ESDPT in the 6 HIQ dimer, femtosecond dynamics and a kinetic isotope effect provide indications for a stepwise ESDPT process in the 6 HIQ/7AI heterodimer, in which 6 HIQ (deuterated 6 HIQ) delivers the pyrrolyl proton (deuteron) to 7AI (deuterated 7AI) in less than 150 fs, forming an intermediate with a charge-transfer-like ion pair, followed by the transfer of a pyrrolyl proton (deuteron) from cation-like 7AI (deuterated 7AI) to the pyridinyl nitrogen of the anion-like 6 HIQ (deuterated 6 HIQ) in approximately 1.5+/-0.3 ps (3.5+/-0.3 ps). The barrier of second proton transfer is estimated to be 2.86 kcal mol(-1) for the 6 HIQ/7AI heterodimer.


Assuntos
Indóis/química , Modelos Químicos , Prótons , Teoria Quântica , Quinolinas/química , Pareamento de Bases , Dimerização , Ligação de Hidrogênio , Indóis/síntese química , Indóis/efeitos da radiação , Estrutura Molecular , Quinolinas/síntese química , Quinolinas/efeitos da radiação
20.
J Org Chem ; 72(25): 9604-8, 2007 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-17997571

RESUMO

Condensation between truxenone (8) and the lithium acetylide derived from 0.9, 2.5, and 5.0 equiv of 1-ethynyl-2-(phenylethynyl)benzene produced the corresponding benzannulated enediynyl alcohol 9, diol 14, and triol 16, respectively. On exposure of these alcohols to thionyl chloride, cascade cyclization reactions occurred to furnish polycyclic compounds 13, 15, and 18 in a single operation. The unusual architectures of these polycyclic compounds were established by NMR spectroscopy and X-ray structure analyses.

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