Interpersonal Perceptual Tendencies and Adjustment in Chinese Adolescents: Testing the Mediating Role of Peer Relationship.

Accuracy and assumed similarity are the most central topics in the research area of interpersonal perception. These two interpersonal perceptual tendencies have been demonstrated to have beneficial effects on adults' psychological functioning independently. However, how and why they influence adolescent psychological adjustment is less well-understood. The present research aimed to examine the mediating role of peer relationships in the association between these two interpersonal perceptual tendencies and psychological adjustment in adolescents. In the first study, a sample of adolescents in their first year of college (N = 93, 63% girls, Mage = 17.45 years, SD = 0.52) were recruited from a university located in Eastern China. They completed the likableness ratings of Anderson's 200 adjectives. The top 10 personality traits with the lowest and highest likableness values were selected to measure adolescents' personality profiles. In the second study, a round-robin design in a real-life setting, a sample of Chinese adolescents in grades six to nine were recruited from two middle schools (N = 337, Ndyads = 918, 47% girls, Mage = 13.76, SD = 1.15). They were requested to rate themselves and their peers within the same group on various factors. Results revealed that adolescents could form an accurate perception of their peers' personalities and concurrently assume that their peers' personalities are similar to their own. More importantly, accurate interpersonal perception and a biased tendency towards assumed similarity could, directly and indirectly, benefit adolescent psychological adjustment through peer relationships.

Determining sex-specific preoperative haemoglobin levels associated with intraoperative red blood cell transfusion in cardiac surgery: a retrospective cohort study.

BACKGROUND: Anaemic cardiac surgery patients are at greater risk of intraoperative red blood cell transfusion. This study questions the application of the World Health Organization population-based anaemia thresholds (haemoglobin <120 g L-1 in non-pregnant females and <130 g L-1 in males) as appropriate preoperative optimisation targets for cardiac surgery. METHODS: A retrospective cohort study was conducted on adults ≥18 yr old undergoing cardiopulmonary bypass surgery. Logistic regression was applied to define sex-specific preoperative haemoglobin concentrations with reduced probability of intraoperative red blood cell transfusion for cardiac surgery patients. RESULTS: Data on 4384 male and 1676 female patients were analysed. Binarily stratified multivariable logistic regression odds of receiving intraoperative red blood cell transfusion increased in cardiac surgery patients >45 yr old (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.33-2.55), surgery urgency <30 days (OR 2.03; 95% CI 1.66-2.48), combined coronary artery bypass grafting and valve surgery, or other surgery types (OR 2.24; 95% CI 1.87-2.67), and female sex (OR 1.92; 95% CI 1.62-2.28). The odds decreased by 8.4% with each 1 g L-1 increase in preoperative haemoglobin (OR 0.92; 95% CI 0.91-0.92). Logistic regression predicted females required a preoperative haemoglobin concentration of 133 g L-1 and males 127 g L-1 to have a 15% probability of intraoperative transfusion. CONCLUSIONS: The World Health Organization female anaemia threshold of haemoglobin <120 g L-1 disproportionately disadvantages female cardiac surgery patients. A preoperative haemoglobin concentration ≥130 g L-1 in adult cardiac surgery patients would minimise their overall probability of intraoperative red blood cell transfusion to <15%.

Isolation and Anticancer Progression Evaluation of the Chemical Constituents from Bridelia balansae Tutcher.

The dichloromethane extract of the roots of Bridelia balansae Tutcher (Phyllanthaceae) was found to show potential anticancer activity against HCT116 colorectal cancer cell. Our bioassay-guided phytochemical investigation of the roots of B. balansae led to the identification of 14 compounds including seven lignans (1-7), three phenylbenzene derivatives (8-10), two flavanone (11-12), and two triterpenoids (13-14). Among them, 4'-demethyl-4-deoxypodophyllotoxin (1) is the first aryltetralin lignan compound identified from this plant species. In addition, the stereochemistry of 1 was validated by X-ray crystallography for the first time, and its distinguished cytotoxic effect on HCT116 cells with an IC50 value at 20 nM was induced via an apoptosis induction mechanism. Compound 1 could also significantly decrease the migration rate of HCT116 cells, indicating its potential application against cancer metastasis. The western blot analysis showed that 1 has the potential to inhibit cell proliferation and metastasis. Treatment of 1 resulted in the downregulation of matrix metalloproteinases 2 (MMP2) and p-Akt, while p21 was upregulated. Collectively, the present study on the phytochemical and biological profile of B. balansae has determined the plant as a useful source to produce promising anticancer lead compounds.

Differentiable Logic Policy for Interpretable Deep Reinforcement Learning: A Study From an Optimization Perspective.

The interpretability of policies remains an important challenge in Deep Reinforcement Learning (DRL). This paper explores interpretable DRL via representing policy by Differentiable Inductive Logic Programming (DILP) and provides a theoretical and empirical study of DILP-based policy learning from an optimization perspective. We first identified a fundamental fact that DILP-based policy learning should be solved as a constrained policy optimization problem. We then proposed to use Mirror Descent for policy optimization (MDPO) to deal with the constraints of DILP-based policies. We derived the closed-form regret bound of MDPO with function approximation, which is helpful to the design of DRL frameworks. Moreover, we studied the convexity of DILP-based policy to further verify the benefits gained from MDPO. Empirically, we experimented MDPO, its on-policy variant, and 3 mainstream policy learning methods, and the results verified our theoretical analysis.

Longitudinal links among paternal and maternal harsh parenting, adolescent emotional dysregulation and short-form video addiction.

BACKGROUND: Due to its diversifying and appealing content, short-form videos have developed very rapidly since its emergence, with more and more users enjoying the transient pleasures from such videos, which have triggered widespread concern over the detrimental influence of short-form video addiction on adolescent health. OBJECTIVE: The present study intended to examine the longitudinal relations among paternal/maternal harsh parenting, adolescents' emotional dysregulation and their short-form video addiction using a cross-lagged longitudinal design. PARTICIPANTS AND SETTING: We recruited a sample of 1064 adolescent students from two middle schools located in rural areas of eastern China. METHODS: Adolescents reported on paternal and maternal harsh parenting, their own emotional dysregulation and short-form video addiction at three time points across two years. Autoregressive and cross-lagged models were analyzed using three-wave variables to test the associations among parental (maternal) harsh parenting, adolescent emotional dysregulation, and short-form video addiction. A multi-group analysis was used to test for potential gender differences in the model. RESULTS: We found that harsh fathering but not harsh mothering contributed to adolescent emotional dysregulation, which in turn predicted adolescent short-form video addiction. However, the reverse longitudinal relationships did not exist. Multiple group analyses revealed that the predictive effect of harsh fathering on adolescent emotional dysregulation was stronger in boys. CONCLUSIONS: Our findings help clarify the complex relationships among harsh parenting, adolescent emotional dysregulation and short-form addiction, providing more effective guidance for prevention against adolescent short-form video addiction.

Cognitive reactivity and emotional dysregulation mediate the relation of paternal and maternal harsh parenting to adolescent social anxiety.

BACKGROUND: Extant models of the association between harsh parenting and social anxiety among adolescents are mostly partial mediation models, leaving much of the relationship unaccounted for. OBJECTIVE: The current study intends to test a two-mediator model in which adolescents' cognitive reactivity and emotional dysregulation were assumed to mediate the potential impact of harsh parenting on their social anxiety. PARTICIPANTS AND SETTINGS: A sample of 726 adolescent students with their parents was recruited from two middle schools located in a provincial city of Northern China. METHODS: Both fathers and mothers were required to report on their spouse's harsh parenting practices. The "Behind your back" task was used to assess cognitive reactivity of adolescents who also reported on their emotional dysregulation and social anxiety. Moderated mediation model and simple slope analyses were used to examine the meditational relations and the moderating role of child sex. RESULTS: For the current model, cognitive reactivity and emotional dysregulation could completely mediate the potential influence of harsh fathering and harsh mothering on adolescents' social anxiety. Moreover, harsh fathering has a greater effect on adolescents' social anxiety than harsh mothering, especially for girls. CONCLUSIONS: Cognitive reactivity in conjunction with emotional dysfunction can better account for the relationship from harsh fathering and harsh mothering to adolescents' social anxiety.

The Antiviral Effects of Jasminin via Endogenous TNF-α and the Underlying TNF-α-Inducing Action.

Previous studies have reported that recombinant tumor necrosis factor (TNF)-α has powerful antiviral activity but severe systematic side effects. Jasminin is a common bioactive component found in Chinese herbal medicine beverage "Jasmine Tea". Here, we report that jasminin-induced endogenous TNF-α showed antiviral activity in vitro. The underlying TNF-α-inducing action of jasminin was also investigated in RAW264.7 cells. The level of endogenous TNF-α stimulated by jasminin was first analyzed by an enzyme-linked immunosorbent assay (ELISA) from the cell culture supernatant of RAW264.7 cells. The supernatants were then collected to investigate the potential antiviral effect against herpes simplex virus 1 (HSV-1). The antiviral effects of jasminin alone or its supernatants were evaluated by a plaque reduction assay. The potential activation of the PI3K-Akt pathway, three main mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-κB signaling pathways that induce TNF-α production were also investigated. Jasminin induces TNF-α protein expression in RAW264.7 cells without additional stimuli 10-fold more than the control. No significant up-expression of type I, II, and III interferons; interleukins 2 and 10; nor TNF-ß were observed by the jasminin stimuli. The supernatants, containing jasminin-induced-TNF-α, showed antiviral activity against HSV-1. The jasminin-stimulated cells caused the simultaneous activation of the Akt, MAPKs, and NF-κB signal pathways. Furthermore, the pretreatment of the cells with the Akt, MAPKs, and NF-κB inhibitors effectively suppressed jasminin-induced TNF-α production. Our research provides evidence that endogenous TNF-α can be used as a strategy to encounter viral infections. Additionally, the Akt, MAPKs, and NF-κB signaling pathways are involved in the TNF-α synthesis that induced by jasminin.

Critical Current Density and Meissner Effect of Smart Meta-Superconductor MgB2 and Bi(Pb)SrCaCuO.

The smart meta-superconductor MgB2 and Bi(Pb)SrCaCuO increase the superconducting transition temperature (TC), but the changes in the transport critical current density (JC) and Meissner effect are still unknown. Here, we investigated the JC and Meissner effect of smart meta-superconductor MgB2 and Bi(Pb)SrCaCuO. The use of the standard four-probe method shows that Y2O3:Eu3+ and Y2O3:Eu3++Ag inhomogeneous phase significantly increase the JC, and JC decreases to a minimum value at a higher temperature. The Meissner effect was measured by direct current magnetization. The doping of Y2O3:Eu3+ and Y2O3:Eu3++Ag luminescent inhomogeneous phase causes a Meissner effect of MgB2 and Bi(Pb)SrCaCuO at a higher temperature, while the non-luminescent dopant reduces the temperature at which samples have Meissner effect. The introduction of luminescent inhomogeneous phase in conventional MgB2 and copper oxide high-temperature Bi(Pb)SrCaCuO superconductor increases the TC and JC, and Meissner effect is exerted at higher temperature. Therefore, smart meta-superconductivity is suitable for conventional and copper oxide high-temperature superconductors.

Therapeutic potential of Moringa oleifera seed polysaccharide embedded silver nanoparticles in wound healing.

Wound healing is a complicated process that influences patient's life quality. Plant-based polysaccharide has recently gained interest in its use in wound dressing materials because of its biological compatibility, natural abundance, and ideal physiochemical properties. The present study reveals the potential of polysaccharide isolated from Moringa oleifera seed (MOS-PS) and its nanocomposite with silver (MOS-PS-AgNPs) as alternative materials for wound dressing. First, MOS-PS was isolated and structurally characterized by TLC, HPLC, FTIR, NMR, and GPC analyses. A green and simple method was used to synthesize AgNPs using MOS-PS as a stabilizing and reducing agent. The size, morphology, and structure of the MOS-PS-AgNPs were characterized by UV-Vis spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and zeta potential analysis. The results showed that the MOS-PS-AgNPs were spherically shaped, having no cytotoxicity toward mouse fibroblasts cells and promoting their in-vitro migration. Moreover, the MOS-PS-AgNPs displayed strong anti-microbial activity against wound infectious pathogenic bacteria. Finally, the MOS-PS-AgNPs were used for dressing animal wounds and its preliminary mechanism was studied by RT-PCR and histological analysis. The results showed that the MOS-PS-AgNPs can promote wound contraction and internal tissue growth well. Overall, our results indicated that the MOS-PS-AgNPs might be an excellent candidate for use as an optimal wound dressing material.

Relationship between the TC of Smart Meta-Superconductor Bi(Pb)SrCaCuO and Inhomogeneous Phase Content.

A smart meta-superconductor Bi(Pb)SrCaCuO (B(P)SCCO) may increase the critical transition temperature (TC) of B(P)SCCO by electroluminescence (EL) energy injection of inhomogeneous phases. However, the increase amplitude ΔTC (ΔTC=TC-TC,pure) of TC is relatively small. In this study, a smart meta-superconductor B(P)SCCO with different matrix sizes was designed. Three kinds of raw materials with different particle sizes were used, and different series of Y2O3:Sm3+, Y2O3, Y2O3:Eu3+, and Y2O3:Eu3++Ag-doped samples and pure B(P)SCCO were prepared. Results indicated that the TC of the Y2O3 or Y2O3:Sm3+ non-luminescent dopant doping sample is lower than that of pure B(P)SCCO. However, the TC of the Y2O3:Eu3++Ag or Y2O3:Eu3+ luminescent inhomogeneous phase doping sample is higher than that of pure B(P)SCCO. With the decrease of the raw material particle size from 30 to 5 µm, the particle size of the B(P)SCCO superconducting matrix in the prepared samples decreases, and the doping content of the Y2O3:Eu3++Ag or Y2O3:Eu3+ increases from 0.2% to 0.4%. Meanwhile, the increase of the inhomogeneous phase content enhances the ΔTC. When the particle size of raw material is 5 µm, the doping concentration of the luminescent inhomogeneous phase can be increased to 0.4%. At this time, the zero-resistance temperature and onset transition temperature of the Y2O3:Eu3++Ag doped sample are 4 and 6.3 K higher than those of pure B(P)SCCO, respectively.

Paternal and Maternal Harsh Parenting and Chinese Adolescents' Social Anxiety: The Different Mediating Roles of Attachment Insecurity With Fathers and Mothers.

Although negative parenting and attachment insecurity have been demonstrated to place children at risk for social anxiety, the different roles of fathers and mothers in this association need to be further clarified. This study examined the different mediating roles of attachment insecurity with fathers and mothers in the association between harsh parenting and social anxiety among Chinese adolescents. A sample of 395 students in the sixth through eighth grades with their parents was enlisted as participants of this survey from two public middle schools located in Northern China. Parents were required to report on their harsh parenting, and students were asked to report on their social anxiety and perceived attachment insecurity with both parents. The results demonstrated that both paternal harsh parenting and maternal harsh parenting were positively associated with attachment insecurity with both parents. More importantly, we found that attachment insecurity with mothers partially mediated the association between maternal harsh parenting and adolescent social anxiety but completely mediated the relation of paternal harsh parenting to adolescent social anxiety. These results expanded extant understandings on the associations among harsh parenting, attachment insecurity, and child social anxiety by taking the different roles of both parents into consideration.

Divergent syntheses of okaramines C, J, L, and S-U.

The total synthesis of six novel okaramines (C, J, L, and S-U) was accomplished with a precise synthesis scheme involving a few steps and a practical yield of 6.7%-23% was obtained. The significance of this study includes the design of a successful and convenient synthesis method for preparation of 3a-hydroxy-pyrrolo[2,3-b]-indole and C-7 prenylated l-tryptophan derivatives using a nucleophilic attack of cyclopropylazetoindoline and an aza-Claisen rearrangement of N-reverse-prenyl tryptophan, respectively.

GANE: A Generative Adversarial Network Embedding.

Network embedding is capable of providing low-dimensional feature representations for various machine learning applications. Current work focuses on: 1) designing the embedding as an unsupervised learning task to explicitly preserve the structural connectivity in the network or 2) generating the embedding as a by-product during the supervised learning of a specific discriminative task in a deep neural network. In this paper, we aim to take advantage of these two lines of research in the view of multi-output learning. That is, we propose a generative adversarial network embedding (GANE) model to adapt the generative adversarial framework to achieve the network embedding learning during the specific machine learning tasks. GANE has a generator to generate link edges, and a discriminator to distinguish the generated link edges from real connections (edges) in the network. Wasserstein-1 distance is adopted to train the generator to gain better stability. GANE is further extended by utilizing the pairwise connectivity of vertices to preserve the structural information in the original network. Experiments with real-world network data sets demonstrate that our models constantly outperform state-of-the-art solutions with significant improvements for the tasks of link prediction, clustering, and network alignment.

Smart meta-superconductor MgB2 constructed by the dopant phase of luminescent nanocomposite.

On the basis of the idea that the injecting energy will improve the conditions for the formation of Cooper pairs, a smart meta-superconductor (SMSC) was prepared by doping luminescent nanocomposite Y2O3:Eu3+/Ag in MgB2. To improve the superconducting transition temperature (TC) of the MgB2-based superconductor, two types of Y2O3:Eu3+/Ag, which has the strong luminescence characteristic, with different sizes were prepared and marked as m-Y2O3:Eu3+/Ag and n-Y2O3:Eu3+/Ag. MgB2 SMSC was prepared through an ex situ process. Results show that when the dopant content was fixed at 2.0 wt.%, the TC of MgB2 SMSC increased initially then decreased with the increase in the Ag content in the dopant. When the Ag content is 5%, the TC of MgB2 SMSC was 37.2-38.0 K, which was similar to that of pure MgB2. Meanwhile, the TC of MgB2 SMSC doped with n-Y2O3:Eu3+/Ag increased initially then decreased basically with the increase in the content of n-Y2O3:Eu3+/Ag, in which the Ag content is fixed at 5%. The TC of MgB2 SMSC doped with 0.5 wt.% n-Y2O3:Eu3+/Ag was 37.6-38.4 K, which was 0.4 K higher than that of pure MgB2. It is thought that the doping luminescent nanocomposite into the superconductor is a new means to improve the TC of SMSC.

Harsh parenting and adolescent aggression: Adolescents' effortful control as the mediator and parental warmth as the moderator.

Although researchers have examined the potential contribution of harsh parenting to child aggression, they have rarely explored how one parent's harsh discipline could interact with warmth by another parent to affect child aggression. We sought to clarify whether the impact of harsh parenting by one parent on child effortful control could be buffered by warmth of the other parent, further reducing the likelihood of child aggression. 867 adolescents were chosen from two public middle schools situated in Jinan, the provincial city in Northern China. Data were gathered with adolescents reporting effortful control, their parents reporting harsh parenting, and their classmates nominating aggressive peers. A moderated mediation model was used to test the mediating and moderating hypotheses. Results indicated that adolescent effortful control partially mediated the relation of harsh fathering to adolescent aggression and completely mediated the relation of harsh mothering to adolescent aggression. Moreover, harsh fathering was only negatively associated with effortful control among adolescents with low maternal warmth and harsh mothering was only negatively associated with effortful control among adolescents with low paternal warmth, thus lowering the risk for aggression. The main conclusion is that harsh parenting by one parent could only indirectly impact on adolescent aggression via the mediator of effortful control only for adolescents with low warmth by the other parent. Our findings add to extant understandings on how different parenting practices by both parents may interact to influence children's aggressive behaviors.

Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer.

A series of benzimidazole carboxamide derivatives have been synthesized and characterized by 1H-NMR, 13C-NMR and HRMS. PARP inhibition assays and cellular proliferation assays have also been carried out. Compounds 5cj and 5cp exhibited potential anticancer activities with IC50 values of about 4 nM against both PARP-1 and PARP-2, similar to the reference drug veliparib. The two compounds also displayed slightly better in vitro cytotoxicities against MDA-MB-436 and CAPAN-1 cell lines than veliparib and olaparib, with values of 17.4 µM and 11.4 µM, 19.8 µM and 15.5 µM, respectively. The structure-activity relationship based on molecular docking was discussed as well.

[Chemical constituent analysis for seeds of Celosia argentea by UPLC-ESI-Q-TOF-MS].

This Paper aimed to analyze and identify the chemical constituents from the seeds of Celosia argentea by UPLC-ESI-Q-TOF-MS. The analysis was performed on an ACQUITY HSS T3 reverse phase column(2.1 mm ×100 mm, 1.8 µm). The mobile phase consisting of 0.1% formic acid acetonitrile and 0.1% aqueous formic acid was used for gradient elution, and the flow rate was 0.4 mL·min~(-1). Mass spectrometry was applied for the qualitative analysis under positive and negative ionization modes and ESI ion source. Data was analyzed by Masslynx 4.1 software, literatures in SciFinder database, and standards. A total of 49 compounds, including 14 triterpenoids, 17 flavonoids, 11 cyclic peptides, 2 phenols, 2 organic acids, and 3 steroids were putatively identified. Among them, 19 compounds were firstly reported from this species. In-depth chemical constituent analysis for the seeds of C. argentea were accomplished here, and the findings could lay a good foundation for its quality control and clarifying the material basis of its efficacy.

Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities.

Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme essential to pyrimidine de novo biosynthesis, which serves as an attractive therapeutic target for the treatment of autoimmune disorders. A novel series of hDHODH inhibitors was developed based on a lead which was obtained by a medicinal chemistry exploration. Most compounds showed moderate to significant potency against hDHODH, compounds 5d, 5e, and 6a effectively inhibited the activities of hDHODH with IC50 values from 0.9 to 2.8 µM. Further studies showed that compound 5e also effectively suppressed proliferation of the activated PBMCs (IC50 = 20.35 µM). Surprisingly, compound 5e also showed anti-pulmonary fibrotic activity similar to that of pirfenidone in vitro assay. Therefore, compound 5e might have potential to be developed as a novel hDHODH inhibitors for autoimmune diseases therapy.

Synthesis of Javanicunines A and B, 9-Deoxy-PF1233s A and B, and Absolute Configuration Establishment of Javanicunine B.

Javanicunines A-B and 9-deoxy-PF1233s A-B belong to a family of natural diketomorpholines with a unique isopropenyl group at C-10b or C-5a and a hydroxyl group at C-11a or C-10b. We herein reported the first total synthesis of javanicunines A-B and 9-deoxy-PF1233s A-B. Pivotal features of the synthesis included a nucleophilic substitution reaction, followed by a Davis' oxaziridine oxidation to assemble javanicunines A-B, and a chemoselective and stereoselective oxidation with Murray's reagent to install the requisite C-10b hydroxyl group in 9-deoxy-PF1233s A-B. The present synthesis also established the absolute configuration of javanicunine B.

Topological Luminophor Y2O3:Eu3++Ag with High Electroluminescence Performance.

Improving luminescent intensity is a significant technical requirement and scientific problem for the luminescent performance of fluorophor materials through the ages. The process control and luminescence performance still limit the developments of luminescent intensity even though it can be improved partly by covering or magnetron sputtering of precious metals on the surface of the fluorophore materials. On the basis of the improvement of luminescence center radiative transition rate by surface plasma resonance and Y2O3:Eu3+ microsheet phosphors, a fundamental model for topological luminophor Y2O3:Eu3++Ag was designed through referencing the concepts of topological materials to enhance luminescent performance by composite luminescence, which is composed of Eu3+ centric electroluminescence and surface plasma-enhanced photoluminescence by Ag. The topological luminophor Y2O3:Eu3++Ag was successfully synthesized with an asymmetric-discrete Ag nanocrystal topological structure on the surface just via illumination. Experimental results suggest that the luminescence performance of topological luminophor Y2O3:Eu3++Ag increased by about 300% compared to that of Y2O3:Eu3+ phosphors in the same conditions. The design of a topological luminophor provides a new approach to further improve the luminescent intensity of phosphors.