RESUMO
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
Assuntos
Tecido Adiposo/efeitos dos fármacos , Hipolipemiantes/síntese química , Isoflavonas/síntese química , Lipídeos/sangue , Fígado/enzimologia , Alanina Transaminase/metabolismo , Animais , Aspartato Aminotransferases/metabolismo , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Hipolipemiantes/química , Hipolipemiantes/farmacologia , Isoflavonas/química , Isoflavonas/farmacologia , Fígado/patologia , Masculino , Estrutura Molecular , Substâncias Protetoras/síntese química , Substâncias Protetoras/química , Substâncias Protetoras/farmacologia , Ratos , Ratos Sprague-Dawley , Solubilidade , Triglicerídeos/sangueRESUMO
The title compound, C(18)H(16)O(4), is composed of a benzopyran-one core with a 4-methoxy-phenyl subsituent in the 3-position and an additional eth-oxy group in the 7-position. The benzopyran-one ring is not coplanar with the benzene ring, the dihedral angle between them being 41.76â (7)°. The meth-oxy and eth-oxy substituents are nearly coplanar with the ring systems to which they are attached. Individual mol-ecules are linked by two kinds of inter-molecular hydrogen bonds into chains containing classical R(2) (2)(8) rings. The chains are further assembled by aromatic F-tape and T-tape stacking inter-actions and additional inter-molecular hydrogen bonding to give a two-dimensional network.
RESUMO
In the title compound, [Ni(H2O)6](C17H13O7S)2.8H2O, the NiII atom is located on an inversion centre in the space group P2(1)/c. The [Ni(H2O)6]2+, C17H13O7S- and H2O components form many hydrogen bonds and there are pi-pi stacking interactions between the isoflavone units. The hydrogen bonds, pi-pi stacking interactions and electrostatic interactions between the cation and anions link the components into a three-dimensional structure.
