RESUMO
INTRODUCTION: Manipulation of percutaneous compression of the trigeminal ganglion (PCTG) for trigeminal neuralgia (TN) can lead to significant haemodynamic changes, which were termed trigemino cardiac reflex (TCR). Nevertheless, many studies indicated that atropine pretreatment can reduce the incidence of bradycardia and cardiac arrest, but do not take precautions against abrupt rise of blood pressure. AIM: The purpose of our study was to compare control group {patients receiving Sodium Nitro-Prusside (SNP) pretreatment before PCTG} with study groups (patients receiving different doses of atropine combined with SNP pretreatment before PCTG) in cardiovascular parameters {Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Heart Rate (HR)} at 5 periods during Total Intravenous Anaesthesia (TIVA). MATERIALS AND METHODS: In total, 120 patients, who underwent PTCG, were enrolled and randomly assigned into control group {group A (SNP pretreatment before PCTG, n=29)} and study groups {group B (0.002mg /kg atropine combined with SNP pretreatment before PCTG, n=30), C (0.004mg/kg atropine pretreatment before PCTG, n=31) and D (0.006mg/kg atropine combined with SNP pretreatment before PCTG, n=30)}, the relationship between haemodynamic changes and using atropine pretreatment or not was compared. Cardiovascular parameters were measured at five periods: preoperative (T0); before puncture (T1); during compression (T2); 1 min after the compression ended (T3); and 1 min after the procedure ended (T4). Multivariate analysis of variance (MANOVA) and Pearson's χ(2) test were used, and a value of p < 0.05 was considered statistically significant. RESULTS: Compared with the group A, means of SBP and DBP in the study groups (group B, C and D) were not observed significant differences at all time points (p>0.05), the mean values of HR showed significant differences, when compared to group C and group D at T2 and T3 (p<0.001). Meanwhile, means of SBP, DBP and HR comparison in the same group were observed between T1 and T2, to the group A, B and D, means of HR (p>0.05 vs. T1) indicated significant differences, however, there was no significant difference in group C (p>0.05). Furthermore, the incidence of post-compression tachycardia was observed in each group. CONCLUSION: By comparison, it seemed that 0.004mg/kg atropine pretreatment before PCTG was more reasonable for preventing significant haemodynamic changes.
RESUMO
BACKGROUND: Percutaneous compression of the trigeminal ganglion (PCTG) is an alternative surgical treatment for trigeminal neuralgia (TN). Manipulation of PCTG can lead to significant hemodynamic changes, which may increase the risk of cardiovascular complications. However, to our knowledge, few studies have focused on anesthesia experience during PCTG as treatment for TN so far. It was our primary focus on how to ensure the stability of hemodynamics during our clinical anesthesia experience. This study aimed to compare the study group (using sodium nitroprusside [SNP] as soon as the puncture began) with the control group (without using SNP as soon as the puncture began) to investigate cardiovascular parameters (systolic blood pressure [SBP], diastolic blood pressure [DBP], and heart rate [HR]) at 5 periods during total intravenous anesthesia. METHODS: A total of 256 patients who underwent PTCG were enrolled and randomly assigned into the study group (n=137) (using SNP as soon as the puncture began) and the control group (n=119) (without using SNP as soon as puncture began); the relationship between the hemodynamic changes and using SNP or without using SNP was compared. Blood pressure and HR were measured at 5 periods: preoperative (T1), before puncture (T2), during compression (T3), 1 minute after compression ended (T4), and 1 minute after the procedure ended (T5). Multivariate analysis of variance and the Pearson χ test were used, and a value of P<0.05 was considered statistically significant. RESULTS: The mean values of SBP were higher in the control group at the evaluation during T3 (P<0.001 vs. control), T4 (P<0.05 and P=0.040 vs. control), and T5 (P<0.05 and P=0.037 vs. control) and DBP was the only observed significant difference during T3 (P<0.001 vs. control), when compared with the study group. Meanwhile, means of SBP, DBP, and HR comparison in the same group were observed between T2 and T3. In the control group, means of SBP (P<0.001 vs. T2), DBP (P<0.001 vs. T2), and HR (P<0.001 vs. T2) showed significant differences in comparison with control group; means of HR (P<0.001 vs. T2) was the only observed significant difference between T2 and T3 in the study group. However, PTCG elicited significant abrupt bradycardia during T3 in almost all patients. CONCLUSIONS: The control group and the study group were not able to prevent bradycardia elicited during PTCG. Compared with control group, dramatic elevations of the systemic blood pressure can be prevented using intravenous drip SNP as soon as the puncture began during total intravenous anesthesia in the study group. Our findings verify that intravenous drip SNP is an effective method to control abrupt rise of blood pressure.
