RESUMO
Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is predominantly due to corneal scarring and neovascularization caused by inflammation. In the infected cornea, HSV can activate innate and adaptive immune responses of host cells, which triggers a cascade of reactions that leads to the release of inflammatory cytokines, chemokines, microRNA, and other regulatory factors that have stimulating or inhibitory effects on tissue. Physiologically, host cells show homeostasis. In this review, we summarize the factors involved in HSK pathogenesis from the perspective of immunity, molecules, and pathological angiogenesis. We also describe in detail the pathogenesis of chronic inflammatory lesions of the corneal stroma in response to HSV-1 infection.
Assuntos
Herpes Simples/imunologia , Herpesvirus Humano 1/patogenicidade , Ceratite Herpética/imunologia , Animais , Substância Própria/patologia , Citocinas , Glicoproteínas , Humanos , Imunidade/fisiologia , MicroRNAs , Linfócitos TRESUMO
OBJECTIVE: To study the chemical constituents of Polygala telephioides. METHOD: The compounds were isolated and purified on macroporous resin, silica gel, Sephadex LH-20, Chromatorex ODS column chromatograph and the structures were determined based on the spectral and chemical evidences. RESULT: Four compounds were obtained and characterized as telephiose G, telephiose D, isomangiferin, quescetin 3-O-beta-D-glucopyranoside, respectively. CONCLUSION: Compounds 2-4 were obtained from this plant for the first time and the compound 2 (telephiose G) was a new compound.
