1.
Palladium-Catalyzed Regioselective Insertion of Carbenes into γ-C(sp3)-H Bonds of Aliphatic Amines.
Org Lett
; 26(13): 2523-2528, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38536882
RESUMO
A migratory insertion of carbenes into distal γ-C(sp3)-H bonds of aliphatic amines has been successfully developed. The synergistic interplay among a palladium catalyst, picolinamide directing group, a carefully selected base additive, and an essential ligand proved crucial in achieving high yields. These findings hold significant value for advancing the exploration of regioselective carbene insertions into nonactivated C(sp3)-H bonds.