RESUMO
Visit to high altitude with its hypoxic hypobaric environment poses various physiological and biochemical challenges to a human body. If the body is not able to cope up to this changed environment, it leads to various maladies of high altitude like high altitude cerebral oedema, high altitude pulmonary oedema and spontaneous vascular thrombosis. There are reports of high altitude-induced deep venous thrombosis, pulmonary embolism, mesenteric ischemia etc. We report a unique case of high altitude-induced testicular infarct in a previously healthy individual after a brief stay at the high-altitude region Ladakh.
RESUMO
Immunomodulatory components of helminths offer great promise as an entirely new class of biologics for the treatment of inflammatory diseases. Here, we discuss the emerging themes in helminth-driven immunomodulation in the context of therapeutic drug discovery. We broadly define the approaches that are currently applied by researchers to identify these helminth molecules, highlighting key areas of potential exploitation that have been mostly neglected thus far, notably small molecules. Finally, we propose that the investigation of immunomodulatory compounds will enable the translation of current and future research efforts into potential treatments for autoimmune and allergic diseases, while at the same time yielding new insights into the molecular interface of host-parasite biology.
