1.
Org Lett
; 3(23): 3715-8, 2001 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11700120
RESUMO
[reaction--see text] The semisynthetic conversion of nodulisporic acid A (1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, with an improved spectrum of ectoparasiticidal activity and pharmacokinetic profile relative to the natural product.
Assuntos
Indóis/síntese química , Inseticidas/síntese química , Oxazóis/síntese química , Tiazóis/síntese química , Animais , Sifonápteros , Carrapatos
2.
Bioorg Med Chem Lett
; 10(20): 2371-4, 2000 Oct 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11055358
RESUMO
Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy.
