Assuntos
Distúrbios Distônicos/complicações , Transtornos dos Movimentos/complicações , Transtornos Respiratórios/complicações , Fraturas das Costelas/etiologia , Adulto , Antipsicóticos/efeitos adversos , Distúrbios Distônicos/induzido quimicamente , Humanos , Masculino , Transtornos dos Movimentos/etiologia , Transtornos Psicóticos/tratamento farmacológico , Transtornos Respiratórios/induzido quimicamenteRESUMO
BACKGROUND: Studies on the relation between insight and medication adherence are limited in Chinese populations. METHOD: Eighty Chinese outpatients with mood disorder and on lithium for at least one year were asked to complete an 11-item insight scale. Lithium adherence was determined by: (a) subjective report; (b) doctor's clinical impression; or (c) serum lithium level. RESULTS: The overall insight score (median = 9, range 1-11) exhibited no significant difference between adherent (N = 58, 72.5%) and non-adherent (N = 22, 27.5%) patients. A two-factor model emerged on factor analysis. Lithium adherent (median = 7, range 1-7) patients had a significantly higher score than non-adherent (median = 6, range 0-7) patients on the 'medical help seeking' factor (Mann-Whitney U-test Z = 2.00, P < 0.05) but not the 'perception of illness' factor. CONCLUSION: The overall conceptual structure of insight in Chinese and Western patients appears similar, but further study is required to explore the complexity of Chinese patients' explanatory models of their illness and to enhance the validity of the insight scale.
Assuntos
Antimaníacos/uso terapêutico , Carbonato de Lítio/uso terapêutico , Transtornos do Humor/tratamento farmacológico , Cooperação do Paciente , Adolescente , Adulto , Cognição , Características Culturais , Feminino , Hong Kong , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Chloroform extracts of the root, stem and leaf of Ruta graveolens L. showed significant anti-fertility activity in rats when administered intragastrically on days 1-10 post-coitum. Fractionation of the extracts led to the isolation of chalepensin as the active component with some toxicity. Time-dosing experiments demonstrated that chalepensin acts at the early stages of pregnancy. It is not clear at this stage if the anti-fertility effect is a direct manifestation of chalepensin toxicity.
Assuntos
Anticoncepcionais Pós-Coito , Furocumarinas/farmacologia , Plantas Medicinais/análise , 5-Metoxipsoraleno , Animais , Anticoncepcionais Pós-Coito/isolamento & purificação , Furocumarinas/isolamento & purificação , Metoxaleno/isolamento & purificação , Metoxaleno/farmacologia , Estrutura Molecular , Ratos , Ratos EndogâmicosRESUMO
Yuehchukene, 11beta-(3'-indolyl-7,9alpha,9beta-trimethyl-5beta,8,9,10beta-tetrahydroindano-[2,3- B]indole, a novel dimeric indole alkaloid from the roots of MURRAY A PANICULATA has potent anti-implantation activity in rats at 3 mg/kg P. O. dosing on pregnancy day 2.