RESUMO
Squamous cell carcinoma of the penis is almost exclusively a lesion of uncircumcised older men. It represents about 1% of cancers in men in the United States and 11% to 12% of all cancers in men in countries where circumcision is not routinely practiced. Verrucous carcinoma is an uncommon variant that accounts for only 5% to 16% of all penile squamous cell carcinomas. We describe penile verrucous carcinoma in a 37-year-old white man who had been circumcised in infancy. To our knowledge this is the first case report of verrucous carcinoma in a circumcised man without any predisposing penile anatomic abnormalities.
Assuntos
Carcinoma Verrucoso/patologia , Circuncisão Masculina , Neoplasias Penianas/patologia , Adulto , Biópsia , Carcinoma Verrucoso/cirurgia , Condiloma Acuminado/patologia , Diagnóstico Diferencial , Humanos , Masculino , Doenças do Pênis/patologia , Neoplasias Penianas/cirurgia , Pênis/patologia , Pênis/cirurgiaRESUMO
A previously undescribed variant of granular cell tumor with an interesting plexiform pattern was found in the lower leg of a 10-year-old girl and on the back of a 12-year-old girl. Clinically, the patients presented with intradermal plaques that were accompanied by variable degrees of pain or tenderness. Histopathologic examination revealed granular cell tumors with various sized fascicles, particularly around nerve bundles, in a plexiform pattern. Cytoplasmic granules were PAS positive. Immunohistochemical studies showed tumor cells to be strongly positive with S-100 protein and weakly positive with alpha-1-antichymotrypsin and vimentin. These findings offer further support for a neural origin for granular cell tumors.