Epidemiology of Bone Stress Injuries and Healthcare Utilization in PAC-12 Cross-Country Athletes.

CONTEXT: Bone stress injury (BSI) is common in collegiate athletics. Injury rate and healthcare utilization is not well documented in running athletes. OBJECTIVE: The purpose of this study was to describe the rate, classification, and healthcare utilization in collegiate cross-country runners with BSI. DESIGN: Descriptive Epidemiology Study. SETTING: Sports medicine facilities participating in the PAC-12 Health Analytics Program. PATIENTS OR OTHER PARTICIPANTS: Collegiate cross-country athletes. MAIN OUTCOME MEASURES: Counts of injury and healthcare resources utilized for each injury. Injury rates were calculated based on athlete seasons. RESULTS: A total of 168 BSIs were reported over four seasons from 80 team season (M: 34, F: 46) and 1,220 athlete seasons, resulting in 1,764 AT services and 117 physician encounters. BSIs represented 20% of all injuries reported by cross-country athletes. The average bone stress injury rate was 0.14 per athlete season. Injury rates were higher in female athletes (0.16) compared to males (0.10) and rates were higher in the 2019-2020 season (0.20) compared to the 2020-21(0.14), 2018-2019 (0.12) and 2021-2022 (0.10) seasons. A majority of BSI's occurred in the lower leg (23.8%) and the foot (23.8%). Most injuries were classified as overuse and time-loss (73%) and accounted for the majority of AT services (75%) and physician encounters (73%). On average, there were 10.89 AT services per overuse-TL injury and 12.20 AT service per overuse-NTL injury. Mean occurrence was lower for physician encounters (0.70), prescription medications (0.04), tests (0.75), procedures (0.01), and surgery (0.02) compared to AT services. CONCLUSIONS: BSIs are common in collegiate cross- country runners and require considerable athletic training resources. Athletic trainers should be appropriately staffed for this population and suspected BSIs should b e confirmed with medical diagnosis. Future investigations should track treatment codes associated with BSI to determine best-practice patterns.

Gait asymmetry and running-related injury in female collegiate cross-country runners.

BACKGROUND: Running biomechanics are commonly linked to injury. There is limited evidence on the effects of running speed on asymmetry and the prospective association of asymmetry and injury. The purposes of this study were to describe the degree in asymmetry in biomechanical variables commonly associated with injury, examine the effect of speed on asymmetry, and determine if there were any significant differences in pre-season measures of asymmetry between runners who went on to sustain an injury during the competitive season compared to those who remained healthy. METHODS: Three-dimensional running biomechanics were obtained from twenty-two female collegiate cross-country runners at four different running speeds prior to their season. Asymmetry was quantified using the Symmetry Angle. Participants were followed over the twelve-week season and all time-loss injuries were identified. FINDINGS: There was no significant effect of velocity on asymmetry. Additionally, there were no significant differences in symmetry between runners who sustained an injury (n = 7) and those that remained injury-free (n = 15) during the cross-country season. INTERPRETATION: Clinicians working with runners should expect a high degree of symmetry in running biomechanics when performing gait analyses across running speeds. In regards to injury, caution should be used when linking injury to asymmetry.

Biomechanical Factors Associated With Achilles Tendinopathy and Medial Tibial Stress Syndrome in Runners.

BACKGROUND: There is disagreement in the literature regarding whether the excessive excursion or velocity of rearfoot eversion is related to the development of 2 common running injuries: Achilles tendinopathy (AT) and medial tibial stress syndrome (MTSS). An alternative hypothesis suggests that the duration of rearfoot eversion may be an important factor. However, the duration of eversion has received relatively little attention in the biomechanics literature. HYPOTHESIS: Runners with AT or MTSS will demonstrate a longer duration of eversion but not greater excursion or velocity of eversion compared with healthy controls. STUDY DESIGN: Controlled laboratory study. METHODS: Forty-two runners participated in this study (13 with AT, 8 with MTSS, and 21 matched controls). Participants were evaluated for lower extremity alignment and flexibility, after which a 3-dimensional kinematic and kinetic running gait analysis was performed. Differences between the 2 injuries and between injured and control participants were evaluated for flexibility and alignment, rearfoot kinematics, and 3 ground-reaction force metrics. Binary logistic regression was used to evaluate which variables best predicted membership in the injured group. RESULTS: Injured participants, compared with controls, demonstrated higher standing tibia varus angles (8.67° ± 1.79° vs 6.76° ± 1.75°, respectively; P = .002), reduced static dorsiflexion range of motion (6.14° ± 5.04° vs 11.19° ± 5.10°, respectively; P = .002), more rearfoot eversion at heel-off (-6.47° ± 5.58° vs 1.07° ± 2.26°, respectively; P < .001), and a longer duration of eversion (86.02% ± 15.65% stance vs 59.12% ± 16.50% stance, respectively; P < .001). There were no differences in the excursion or velocity of eversion. The logistic regression (χ2 = 20.84, P < .001) revealed that every 1% increase in the duration of eversion during the stance phase increased the odds of being in the injured group by 1.08 (95% CI, 1.023-1.141; P = .006). CONCLUSION: Compared with healthy controls, runners currently symptomatic with AT or MTSS have a longer duration of eversion but not greater excursion or velocity of eversion. CLINICAL RELEVANCE: Static measures of the tibia varus angle and dorsiflexion range of motion, along with dynamic measures of the duration of eversion, may be useful for identifying runners at risk of sustaining AT or MTSS.

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium.

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) could play a role in the regulation of interleukin (IL)-15 and IL-18, cytokines crucial for angiogenesis and uterine natural killer (uNK) cell recruitment during embryo implantation. We therefore confirmed the endometrial presence of TWEAK/fibroblast growth factor inducible-14 (Fn-14) and documented simultaneously the cytotoxic KIR receptor (NKp46) of uNK cells in the human endometrium while TWEAK, Fn-14, IL-15, and IL-18 mRNA were quantified by real-time polymerase chain reaction in relation to the recruitment of CD56+ cells among fertile control women and patients who had failed to implant after assisted reproduction treatment.