RESUMO
A clinico-pathological report is given of two cases of progressive dementia of fronto-temporal type associated with variable cortical neuronal loss and extensive subcortical and deep white matter gliosis. There was minimal demyelination of white matter, significant gliosis of thalamus and inferior olivary nuclei. The authors review the condition of progressive subcortical gliosis, compare such changes with white matter changes in other dementias, examine the relationship to Kraepelin's disease, contrast the disorder with atypical Pick's dementia, progressive dementia with motor neuron disease and Creutzfeldt-Jakob dementia.
Assuntos
Gliose/patologia , Demência/patologia , Diagnóstico Diferencial , Feminino , Gliose/classificação , Humanos , Pessoa de Meia-Idade , Degeneração NeuralRESUMO
We studied a case of pathologically confirmed Pick's disease. Several of the clinical and computed tomographic (CT) features may be helpful in making an in vivo diagnosis of the disease. In addition, the Golgi impregnation studies showed a unique dendritic histopathologic pattern not previously encountered in any of the degenerative dementias.
Assuntos
Demência/patologia , Complexo de Golgi/ultraestrutura , Tomografia Computadorizada por Raios X , Idoso , Doença de Alzheimer/diagnóstico , Encéfalo/patologia , Demência/diagnóstico , Demência/diagnóstico por imagem , Demência/fisiopatologia , Diagnóstico Diferencial , Humanos , MasculinoRESUMO
A focal aphasic syndrome was the first and outstanding manifestation of a degenerative, presenile dementia in a 67 year old man. Computerised axial tomography showed a strikingly dilated left Sylvian fissure--particularly in its posterior aspect--in the presence of moderate diffuse cortical atrophy. The radiographic findings correlated well with the clinical data. This is the first report of an aphasic disturbance of language as the initial symptom is presenile dementia.
