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Sci Rep ; 10(1): 6465, 2020 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-32296094

RESUMO

Herpes simplex labialis (HSL) is a viral disease that affects the perioral region. No guidelines recommending an effective treatment exist. The treatment of HSL with three different products was examined. Herpatch Serum, a film-forming patch, was compared to Compeed Patches, a set of semiocclusive hydrocolloid patches, and Zovirax Cream (ingredient: 5% acyclovir). In this prospective, randomized, examiner-blind study, 180 patients with recurrent HSL were split into three groups (Compeed: n = 60, Herpatch: n = 60, Zovirax: n = 60) and examined within 24 hours of HSL outbreak (DRKS Registration No.: DRKS00007786). The primary endpoint was healing time. The secondary endpoints were the reaction rate and quality of therapy evaluated by the Clinician's Global Assessment of Therapy (CGAT) and the Subject's Global Assessment of Therapy (SGAT) (0 = no response; 10 = excellent response), respectively. There was no significant difference among the healing times for the different products. The mean (95% confidence interval) was 9.67 days (9.11-10.22) for Compeed, 9.30 days (8.75-9.85) for Herpatch, and 9.80 days (9.30-10.30) for Zovirax. The reaction rate and quality of therapy (CGAT and SGAT) of Herpatch were significantly higher than those of Compeed and Zovirax. Within the study limitations, Herpatch proved to be an effective, non-antiviral alternative in the treatment of HSL.


Assuntos
Antivirais/administração & dosagem , Herpes Labial/terapia , Curativos Oclusivos , Aciclovir/administração & dosagem , Administração Tópica , Adulto , Método Duplo-Cego , Feminino , Humanos , Lábio/efeitos dos fármacos , Lábio/virologia , Masculino , Estudos Prospectivos , Recidiva , Creme para a Pele/administração & dosagem , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
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