Diabetic Retinopathy Screening at the Point of Care (DR SPOC): detecting undiagnosed and vision-threatening retinopathy by integrating portable technologies within existing services.

INTRODUCTION: The aim of this study was to determine the prevalence of diabetic retinopathy (DR) in a low socioeconomic region of a high-income country, as well as determine the diagnostic utility of point-of-care screening for high-risk populations in tertiary care settings. RESEARCH DESIGN AND METHODS: This was a cross-sectional study of patients with diabetes attending foot ulcer or integrated care diabetes clinics at two Western Sydney hospitals (n=273). DR was assessed using portable, two-field, non-mydriatic fundus photography and combined electroretinogram/ pupillometry (ERG). With mydriatic photographs used as the reference standard, sensitivity and specificity of the devices were determined. Prevalence of DR and vision-threatening diabetic retinopathy (VTDR) were reported, with multivariate logistic regression used to identify predictors of DR. RESULTS: Among 273 patients, 39.6% had any DR, while 15.8% had VTDR, of whom 59.3% and 62.8% were previously undiagnosed, respectively. Non-mydriatic photography demonstrated 20.2% sensitivity and 99.5% specificity for any DR, with a 56.7% screening failure rate. Meanwhile, mydriatic photography produced high-quality images with a 7.6% failure rate. ERG demonstrated 72.5% sensitivity and 70.1% specificity, with a 15.0% failure rate. The RETeval ERG was noted to have an optimal DR cut-off score at 22. Multivariate logistic regression identified an eGFR of ≤29 mL/min/1.73 m2, HbA1c of ≥7.0%, pupil size of <4 mm diameter, diabetes duration of 5-24 years and RETeval score of ≥22 as strong predictors of DR. CONCLUSION: There is a high prevalence of vision-threatening and undiagnosed DR among patients attending high-risk tertiary clinics in Western Sydney. Point-of-care DR screening using portable, mydriatic photography demonstrates potential as a model of care which is easily accessible, targeted for high-risk populations and substantially enhances DR detection.

A putative link between pertussis and new onset of gastroesophageal reflux an observational study.

Background: Pertussis is an infectious disease of the respiratory tract with a changing epidemiology. An increasing incidence has been found in the adult population with recurrent infections possibly related to changes in the current vaccine. Is there an association between pertussis infection, refractory cough and atypical gastro-oesophageal reflux (GORD)? Does this magnify and compound respiratory complications? Methods: Observational study which compares post-pertussis (n=103) with non-pertussis patients (n=105) with established GORD. Patients were assessed for laryngopharyngeal reflux and aspiration of refluxate by a novel scintigraphic study. Results: Both groups showed severe GORD in association with high rates of laryngopharyngeal reflux (LPR) and pulmonary aspiration and lung disease. High rates of hiatus hernia and clinical diagnosis of "atypical" asthma showed correlations with pulmonary aspiration. Conclusions: A high level of new onset LPR and lung aspiration has been shown in patients with chronic cough after recent pertussis infection by a novel scintigraphic technique with fused hybrid x-ray computed tomography (SPECT/CT).

Acute oxygen desaturation characterizes pulmonary aspiration in patients with gastroesophageal reflux disease and laryngopharyngeal reflux.

The aim of this study was to characterise pulmonary aspiration of refluxate in patients with gastroesophageal reflux disease (GORD) and laryngopharyngeal reflux (LPR) by continuous pulse oximetry (SpO2) during the supine phase of a scintigraphic reflux study. Variables assessed for significance included age, hiatus hernia, frequency, amplitude of reflux and clearance of reflux from the oesophagus/pharynx. The patients included in this study had established GORD and LPR by clinical history. All patients underwent fused three- dimensional scintigraphic/ X-ray computed tomography (CT) and simultaneous continuous pulse oximetry when supine for 30 minutes. A total of 265 patients (40.4% M, 59.6% F) were studied. Mean age of aspirators was 57.0 years and non-aspirators was 53.5 years. Seven patients had baseline oxygen saturation <95%, with 6/7 showing aspiration by scintigraphy. The remainder had mean baseline saturation of 97.7%. Continuous SpO2 monitoring showed a significant fall in pulmonary aspirators after 20 min of supine acquisition with significant variability. Analysis revealed a cyclic event every 1.5 min in aspirators only. Panel regression analysis showed a significant effect of age, hiatus hernia, pulse rate and reflux frequency on the fall in SpO2. Pulmonary aspiration in patients with LPR and GORD is characterised by acute oxygen desaturation. Variables affecting oxygen desaturation were age, hiatus hernia, pulse rate and reflux frequency. A cyclic event was observed every 1.5 min in aspirators and may be due to reflex homeostatic mechanism attempting to correct perceived hypoxia.

Life lost due to premature deaths in New South Wales, Australia.

This study attempts to measure premature mortality, in addition to overall death rates, in order to provide more information that can be used to develop and monitor health programmes that are aimed at reducing premature (often preventable) mortality in New South Wales (NSW), Australia. Premature years of potential life lost (PYPLL) and valued years of potential life lost methods are applied for mortality data in NSW from 1990 to 2002. Variations in these measures for 2001 are studied further in terms of age, sex, urban/rural residence, and socio-economic status. PYPLL rates for all leading causes of death have declined. It is shown that the average male to female ratio of PYPLLs is highest for accidents, injury and poisoning (3.4:1) followed by mental disorders (2.7:1) and cardiovascular diseases (2.6:1). Although fewer women than men die of cardiovascular diseases, there is a greater proportionate importance of cerebrovascular mortality among women. In order to further reduce premature deaths, programs are required to improve the health of people living in lower socio-economic status areas, especially in rural NSW. Targeted regional or community level programs are required to reduce avoidable deaths due to accidents, injury and poisoning occasioned by motor vehicle accidents, poisoning and suicide among young adults.

Trends in percutaneous coronary interventions in new South Wales, Australia.

This is the first detailed study on percutaneous coronary intervention (PCI) in New South Wales (NSW), Australia. Hospital data for PCIs carried out between 1 July 1990 and 30 June 2002 are analysed. The study explores trends in PCI rates by selected socio-demographic factors, the utilisation of angioplasties vis-a-vis stents, emergency admissions, and selected coexisting conditions which determine the disease status of PCI patients. Logistic regression models are used to study the medical conditions that require both PCI and coronary artery bypass graft (CABG). The PCI rate has grown rapidly at 12.1% per annum, with a particularly rapid increase for persons aged 75+. The rate of multiple stent utilisation increased at 4.6% per annum. Pacific-born and Middle-Eastern-born patients are more than twice as likely as the Australian-born to have diabetes. Factors affecting failure of PCI requiring CABG include perforation and multi-vessel disease. PCI services in public hospitals need to be increased to facilitate the availability of these procedures to all segments of the population, as do targeted community-level programmes to educate high-risk groups in the control of heart diseases.

Seasonality of births and abortions in New South Wales, Australia.

BACKGROUND: Complex seasonal variations in abortions and seasonal trends have been reported worldwide, but there are no data from Australia. MATERIAL/METHODS: Hospital morbidity and birth data were modelled using time series and regression techniques to describe seasonal changes in births and abortions (1989-99) in NSW, Australia. Data were also analysed to determine demographic predictors of abortions. RESULTS: A higher proportion of births in NSW were recorded in March and September-October. Irrespective of the nuptiality the lowest seasonal indices were recorded in February and November. For married women aged 20-49 years, voluntary abortions were significantly higher in February (t=0.04) and significantly lower in April (t<0.001) and June (t=0.03) and non-voluntary abortions were significantly higher in February (t=0.002) and March (t=0.006). There was seasonality in voluntary abortions (F=4.3, p<0.001) and no seasonality in non-voluntary abortions (F=2.4, p=0.01) for never married women aged 20-49 years. As similar to married women, voluntary abortions among never married women were significantly higher in February (t<0.001) and significantly low in April (t=0.009). The lowest number of abortions were in April. Non-voluntary abortions occurred mostly in March for married women. The average number of voluntary abortions were significantly higher for never married women than for married women. CONCLUSIONS: There was a significant seasonality of births and abortions in NSW, Australia, with a peak of conceptions in December/January. Abortions were lowest in April and non-voluntary abortions were peaked in March. These data suggest that the human reproductive behaviour has a close relationship with environmental factors.

Effect of wealth on marital fertility in Sri Lanka.

This study examines the effect of household wealth on marital fertility in Sri Lanka. Data on type of dwelling, availability of vehicles, and electrical equipment in households were combined with estimates of 'typical' rupee values of various elements to generate an index of their wealth. Differentials in value of the wealth indices among sociodemographic subgroups of population are also described. The results of the study showed that, after controlling for other variables, higher levels of household wealth were associated with lower fertility. There were also significant effects of participation of female labour force, ethnicity, age-at-marriage, and parity on current fertility. However, after controlling for wealth and other explanatory variables, the effect of female education was not significant. If the model were to remain constant over time, raising levels of wealth would reduce marital fertility in Sri Lanka.

The epidemiology of cardiac arrests in a Sydney hospital.

AIM: To examine the epidemiology of cardiac arrest (CA) in New South Wales (NSW), Australia, and a large teaching hospital in Sydney and to identify predictors of survival. METHODS: Data from the 1996/97 NSW inpatient statistics collection were analysed. Logistic regression was used to determine predictors of mortality from CA. RESULTS: In 1996/97 in public hospitals, Eastern Sydney Area Health Service (AHS) (47.5), and in private hospitals of Macleay-Hastings District Health Services (DHSs), recorded the highest crude CA rates in NSW with figures of 47.5 and 21.3 per 10,000 hospital separations. Standardised CA rates were highest in Western Sydney, Illawara, Macleay-Hasting, Mid North Coast and Orana DHSs. Most CAs in hospital 'X' occurred after admission and 55.7% occurred in patients admitted with a non-cardiac principal diagnosis, mainly pneumonia. Acute myocardial infarction was the leading diagnosis (28.9%) in patients who suffered CA after admission. Only 32% of CA patients survived to discharge. Age above 65 (odds ratio (OR)=2.284, P=0.006) had the highest effect on cardiac mortality. The longer the patients were in the intensive care unit (OR=0.997, P=0.037), the more likely they were to survive. CONCLUSION: We describe considerable variation in CA rates in NSW. The majority of hospital CAs occur at or soon after admission, and are associated with underlying non-cardiac conditions. Survival following hospital CA is low, but there may be preventable elements. Knowledge of risk factors and epidemiology of hospital CAs may help identify patients at risk of CA.