[Structure and effects of benzodiazepines on hepatic microsomal monooxygenases in rats exposed to environmental temperature]. / Struktura benzodiazepin a ich dzialanie na mikrosomalne monooksygenazy watroby szczurów w podwyzszonej temperaturze otoczenia.

Five benzodiazepines (diazepam, oxazepam, clonazepam, nitrazepam and chlordiazepoxide) were compared with respect to their capacity to affect microsomal aniline hydroxylase, aminopyrine N-demethylase and 4-nitroanisole O-demethylase of rats exposed to the high ambient temperature of 28 degrees C or 35 degrees C. We have stated that the highest effect on the microsomal enzyme activities was observed after chlordiazepoxide, clonazepam or nitrazepam treatments. These results indicate that the presence of nitro group at position 7 or N-oxide at position 4 of benzodiazepine is important for the ability of benzodiazepines to affect the hepatic microsomal enzymes. High environmental temperature modifies the effect of benzodiazepines on tested microsomal enzymes.

[Effect of benzodiazepines on enzyme-metabolizing drugs. III. Activity of microsomal monooxygenases in the rat liver exposed to chlordiazepoxide and elevated environmental temperature]. / Dzialanie benzodiazepin na enzymy metabolizujace leki. III. Aktywnosc mikrosomalnych monooksygenaz watroby szczura w nastepstwie dzialania chlordiazepoksydu i podwyzszonej temperatury otoczenia.

It has been stated that elevation of environment temperature to 28 degrees C or 35 degrees C modifies effects of chlordiazepoxide on activities of rat liver microsomal enzymic systems involved in metabolism of xenobiotics: amidopyrine, aniline and 4-nitroanisole++.