1.
Acta Crystallogr C
; 59(Pt 8): o473-5, 2003 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12909781
RESUMO
The crystal and molecular structure of 1-tert-butyl 4-ethyl (2'R,3'R,5'R,2S,3S)-3-bromomethyl-3-hydroxy-2-[(2'-hydroxy-2',6',6'-trimethylbicyclo[3.1.1]hept-3'-ylidene)amino]succinate, C(21)H(34)BrNO(6), is presented. This compound is an intermediate in the new synthetic route to beta-substituted beta-hydroxyaspartates, which are blockers of glutamate transport.
Assuntos
Aspartame/síntese química , Estrutura Molecular , Aspartame/análogos & derivados , Aspartame/química , Cristalografia por Raios X , Modelos Moleculares
2.
Org Biomol Chem
; 1(11): 1938-42, 2003 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12945776
RESUMO
A short asymmetric synthesis of optically pure beta-substituted beta-hydroxy aspartates is described. The key step is an aldol reaction between a glycine enolate derived from an oxazinone intermediate used as chiral auxiliary and various alpha-keto esters. Excellent diastereomeric excesses are obtained.