The efficacy of different interventions in the treatment of sarcopenia in middle-aged and elderly people: A network meta-analysis.

BACKGROUND: In this study, a meta-analysis system was used to evaluate the effects of 7 methods of treating sarcopenia, including resistance exercise, aerobic exercise, mixed exercise, nutrition, resistance combined with nutrition, mixed exercise combined with nutrition, and electric stimulation combined with nutrition, and their effects on physical function. METHODS: According to the PRISMA guidelines, PubMed, Web of Science, Embase, and other foreign databases, as well as Chinese databases such as China National Knowledge Infrastructure and Wan Fang, the literatures of randomized controlled trials with different intervention measures were searched. ADDIS software was used to compare and rank the results of the network meta-analysis. RESULTS: A total of 2485 patients were included in the 30 randomized controlled trial items. According to the clinical manifestations of sarcopenia, 7 different forms of exercise and nutrition interventions can improve muscle strength, muscle mass, and physical function; in terms of improving muscle strength, resistance exercise has the most significant effect on improving grip strength (MD = 2.58, 95% confidence interval [CI] [1.06-4.07]); resistance exercise combined with nutrition lifting performed best in chair standing test (MD = -2.37, 95% CI [-4.73 to -0.33]). For muscle mass gains, resistance training increased appendicular skeletal muscle mass significantly (MD = 0.90, 95% CI [0.11-1.73]), while resistance exercise combined with nutrition significantly increased fat-free mass (MD = 5.15, 95% CI [0.91-9.43]). For physical activity, resistance training improved walk speed best (MD = 0.28, 95% CI [0.15-0.41]), and resistance exercise combined with nutrition in the best results were seen in the timed up and go test (MD = -2.31, 95% CI [-4.26 to -0.38]). CONCLUSION: Compared with aerobic exercise, mixed exercise, nutrition, resistance combined with nutrition, mixed exercise combined with nutrition, and electric stimulation combined with nutrition, resistance exercise has more advantages in improving muscle mass, strength, and physical function performance. The clinical treatment of sarcopenia with resistance exercise intervention has a better curative effect.

Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis.

Objective: To systematically evaluate the effects of resistance training (RT) on muscle strength and muscle hypertrophy in elderly cancer patients, and to provide dose-response relationships of RT variables that could improve muscle strength and morphology in elderly cancer patients. Method: The Review Manager 5.3 was applied to analyze the 12 literatures (616 participants) through random or fixed effects model and global effect size to examine upper limb strength, lower extremity strength, and muscle hypertrophy. Sub-group analysis was made on five variables: the total number of repeated training times/week, load intensity, exercise frequency/week, exercise duration and gender. This study also examines the heterogeneity and publication bias. Results: Twelve literatures (616 participants, 60-80 years) were included in meta-analysis. RT significantly increased the upper limb muscular strength (SMD = 0.51, 95% CI: 0.10-0.93; Z = 2.41; p = 0.02) and lower extremity strength (SMD = 0.48, 95% CI: 0.28-0.67; Z = 4.82; p < 0.00001), but had no significant effect on muscle morphology(SMD = 0.21, 95% CI: 0.01-0.42; Z = 1.88; p = 0.06). In subgroup analysis for lower extremity muscle strength in elderly male cancer patients, it was found that male intensity of 70-90%1RM, volume of 400-500 times per week, frequencies of 3 times per week, and session of 12-24 weeks, revealed the greatest effect. Funnel plot of the three studies shows that the results were reliable, and no publication bias was found. Conclusion: RT had medium effects on improving muscle strength in elderly cancer patients, but it is not effective in improving muscle hypertrophy. In addition, when RT is performed, different training protocols can have an effect on the growth of muscle strength. Therefore, a lower extremity training protocol with a training intensity of 70-90% 1RM, a total of 400-500 repetitions per week, 3 times per week, and an exercise session of 12-24 weeks is most effective in improving lower extremity strength in elderly male cancer patients.

Effects of flywheel resistance training on the running economy of young male well-trained distance runners.

The study aimed to investigate the effect of flywheel accentuated eccentric loading (AEL) training on the running economy (RE) of young male well-trained distance runners. Twenty-two runners participated and were randomly assigned to the flywheel (FG, n = 12) and the control group (CG, n = 10). Traditional endurance training was performed in both groups three times a week for 6-week, while traditional resistance and flywheel AEL training was added to the CG and FG respectively. Subjects performed the incremental exercise test, squat jump, and countermovement jump (CMJ) before and after training. The results showed that 1) the RE at 65% of peak oxygen consumption (VO2peak), 75% VO2peak, and 85% VO2peak improved significantly after 6 weeks of training (p < 0.01, Effect size (ES) = 0.76; p < 0.01, ES = 1.04; p < 0.01, ES = 1.85) in FG, and the RE of 85% VO2peak in FG was significantly lower than CG (p < 0.05, ES = 0.30); 2) in post-training, both squat jump (p < 0.01, ES = 0.73) and CMJ (p < 0.01, ES = 1.15) performance, eccentric utilization ratio (p < 0.04, ES = 0.44), the rate of force development (RFD) of squat jump (p < 0.05, ES = 0.46), and CMJRFD (p < 0.01, ES = 0.66) were significantly improved in FG. And there are no significant differents in CG group because it was maintain training for our participants. Our findings showed that 1) flywheel AEL training improves the muscles' explosive strength and other neuromuscular functions, and improves the athlete's running economy under 65%, 75%, and 85% VO2peak, which potentially increases endurance performance. 2) Flywheel AEL training can improve the height, RFD, and the eccentric utilization ratio of squat jump and CMJ, and other lower limb elastic potential energy indicators of the young male, well-trained distance runners.

Relationships between Functional Movement Quality and Sprint and Jump Performance in Female Youth Soccer Athletes of Team China.

This study aimed to determine the optimal functional movement screen (FMS) cut score for assessing the risk of sport injury, and to investigate the correlations between functional movement quality and sprint and jump performance. Twenty-four (N = 24) athletes performed all tests in one day at 10−30 min intervals, and the FMS test was performed first, without a warm-up session. After a standard warm-up, athletes then completed the Y-balance Test (YBT), sprint, counter-movement jump (CMJ), and standing long jump (SLJ), in turn. For each test, the best of three attempts was recorded for further analysis. A receiver operating characteristic (ROC) curve and area-under-the-curve (AUC) were used to determine the optimal FMS cut score for assessing the risk of sport injuries, and Spearman's rank correlation analysis was used to quantify associations between functional movement scores and athletic performance. The average FMS score was 16.2 and the optimal FMS cut score for assessing the risk of sport injuries was 14.5. There were moderate relationships between total FMS score and 10−20 m sprint time (r = −0.46, p < 0.05), between In-line Lunge and 0−20 m sprint time (r = −0.47, p < 0.05), between Shoulder Mobility and 0−10 m sprint time (r = −0.48, p < 0.05), and between Trunk-stability Push-up and 10−20 m sprint time (r = −0.47, p < 0.05). Moreover, Hurdle Step score was largely correlated with 0−10 m time (r = −0.51, p < 0.05). For Y-balance, moderate correlations were observed between CMJ height and anterior asymmetry score (r = −0.47, p < 0.05) and posteromedial asymmetry score (r = −0.44, p < 0.05). However, there were no significant associations between YBT performance (asymmetric in three directions and composite score) and sprint performance (p > 0.05). Taken together, the results indicate that a FMS score of 14 is not a gold standard for assessing the risk of injury in all populations; we recommend that the FMS cut score of 14.5 should be the optimal score for assessing risk of injury in young female elite soccer players. Moreover, the FMS and YBT were introduced to assess the quality of functional movements, and they cannot be used to assess sprint and jump performance. Practitioners can use components of the FMS that have similar characteristics to specific sports to assess athletic performance.

Modern physical training concepts and approachs into public physical education in colleges and universities / 中国学校卫生

Abstract@#Public physical education teaching has adopted modern concepts and approachs of physical training to highlight the importance and effectiveness of physical education in colleges and universities in China. These courses have placed an emphasis on the need to attend to the structural integrity of the human body, optimizing the basic action mode and the efficient transmission of the power chain in motion. From the perspective of curriculum education, it is helpful to update ideas surrounding the public physical education curriculum in colleges and universities to enrich the content of public physical education courses provided by these institutions and to improve the scientific nature of training, while also enhancing the physical fitness of college students and promoting lifelong sports consciousness. However, there is insufficient explanation and implementation of modern physical training concepts and approachs into the teaching and process of public sports in colleges and universities. It will be beneficial to improve its top level design, increase policy support, provide better facilities, strengthen the construction of teachers, actively organize enjoyable physical fitness competitions, enrich the teaching content system and clear on the positioning of college physical education, in order to promote the fundamental tasks of school based physical education and the value of school sports. This is also important to ensure a renewal of the concept of the public physical education curriculum in our country, and encourage reform of the curriculum content, teaching mode and teaching methods, while also highlighting the essential function of physical training.

Anxiolytic-like effects of treadmill exercise on an animal model of post-traumatic stress disorder and its mechanism.

BACKGROUND: Many studies have proven the beneficial effects of regular exercise on psychiatric conditions. This study was set to explore the therapeutic effects and the mechanisms of treadmill exercise on a time-dependent sensitization (TDS) model which is a classical animal model for mimicking posttraumatic stress disorder (PTSD). METHODS: Forty-seven rats were randomly assigned to one of four groups: CON (control), TDS (model), EX (treadmill), or SER (sertraline). TDS model was developed to evaluate the anti-PTSD-like effects of moderate treadmill exercise with 4-week running program. High-performance liquid chromatography technology was used to determine the levels of monoamine neurotransmitters in TDS rats. The expression of key proteins in BDNF/PI3K/Akt/CREB signaling pathway were assayed by the Western blot method. RESULTS: The TDS procedures induced behavioral deficiencies. These deficiencies were reversed by treadmill exercise. Subsequent monoamine assays revealed that the treadmill exercise significantly increased serotonin levels in the hippocampus and decreased dopamine levels in the prefrontal cortex. Data from Western blot experiment demonstrated that exercise could normalize the decreased BDNF/TrkB/pAkt/pCREB levels in the hippocampus. CONCLUSIONS: This study deduced that treadmill exercise ameliorated contextual fear conditioning and anxiety-like behavior in TDS model. According to the study, the mechanism involved in alleviating PTSD symptoms by treadmill exercise was due to increased 5-HT levels in the hippocampus and decreased DA levels in the prefrontal cortex. It also involved the upregulation of BDNF and the related PI3K/AKT/CREB signaling pathway.