Causal Relationship Between Obstructive Sleep Apnea and Temporomandibular Disorders: A Bidirectional Mendelian Randomization Analysis.

Objective: This study was conducted to investigate the bidirectional causal relationship between obstructive sleep apnea (OSA) and temporomandibular disorders (TMD). Methods: Using an online pooled dataset of genome-wide association studies (GWAS), a two-sample bi-directional Mendelian randomization (MR) method was implemented. Inverse variance weighting was used as the primary analyses approach, and other methods of MR Egger, weighted median method, MR-Egger, Simple mode, and Weighted mode analysis were conducted as supplements to evaluate the causal relationship between OSA and TMD with odds ratios (OR) and 95% confidence interval (CI). Furthermore, the Cochran Q, MR-Egger, and MR-PRESSO approaches were used to perform the heterogeneity test and multiple validity. Results: The general results of the forward MR analysis indicated that OSA had a significant causal influence on TMD (OR=1.241, 95% CI: 1.009-1.526, P=0.041), but no significant correlation was observed in the reverse MR analysis (IVW: OR=0.975, 95% CI=0.918-1.036, P=0.411). Conclusion: In summary, our research demonstrated a hereditary causative relationship between OSA and TMD, indicating that appropriate intervention is required for both prevention and treatment of TMD.

Use of colloids and crystalloids for perioperative clinical infusion management in cardiac surgery patients and postoperative outcomes: a meta-analysis.

BACKGROUND: The optimal fluid management strategy for patients undergoing cardiac surgery was controversial regarding fluid volume and intraoperative fluid types. This study aimed to assess the correlation between colloids and crystalloids used for perioperative fluid therapy in cardiac surgery patients and postoperative prognosis. METHODS: The Ovid MEDLINE(R) ALL, Embase, and Cochrane Central Register of Controlled Trials databases were searched for eligible studies on fluid management strategies using colloids and crystalloids for cardiac surgery patients published before August 25th, 2023. RESULTS: Ten randomized controlled trials met the eligibility criteria. Compared to the use of crystalloids, the use of colloids, including hydroxyethyl starch (HES), albumin, and gelatine, did not show any differences in mortality, transfusion, acute kidney injury, and atrial fibrillation rates, postoperative blood loss, the length of hospital stay, or the length of intensive care unit (ICU) stay. The results of this meta-analysis showed that the crystalloid group had significantly reduced postoperative chest tube output compared to the colloid group. In the subgroup analysis, the amount of fresh frozen plasma (FFP) infused was significantly lower when using fluid management in the ICU and when using isotonic crystalloids compared to the colloids. In addition, when using fluid management in the ICU, patients in the colloid group had a significant increase in urine volume 24 h after surgery. However, other related factors, including the type of crystalloid solution, type of colloidal solution, and timing of liquid management, did not affect most outcomes. CONCLUSION: Both colloids and crystalloids could be used as alternatives for perioperative fluid management after cardiac surgery. The use of crystalloids significantly reduced the postoperative chest tube output, and the need for FFP infusion decreased significantly with the use of isotonic crystalloids or fluid management during the ICU stay. ICU patients in the colloid group had higher urine output 24 h after surgery. In addition, although the infusion method was not related to most outcomes, the rates of red blood cell and FFP transfusion and postoperative blood loss in the crystalloid group seemed to be lower, which needed to be further studied in high-quality and large-sample RCTs. TRIAL REGISTRATION: PROSPERO, CRD42023415234.

The association between rs16917496 T/C polymorphism of SET8 gene and cancer risk in Asian populations: a meta-analysis.

Epidemiological studies have demonstrated close associations between SET8 rs16917496 T/C polymorphism and cancer risk, but the results of published studies were not consistent. We therefore performed this meta-analysis to explore the associations between rs16917496 T/C polymorphism and cancer risk. Five online databases were searched. Odds ratios (ORs) with a 95% confidence interval (CI) were calculated to assess the association between rs16917496 T/C polymorphism and cancer risk. In addition, heterogeneity, accumulative, sensitivity analysis, and publication bias were conducted to check the statistical power. Overall, 13 publications involving 5878 subjects were identified according to included criteria. No significant cancer risk was observed in genetic model of SET8 rs16917496 T/C polymorphism in Asian populations (C vs. T: OR = 1.04, 95%CI = 0.88-1.23, P = 0.63%; TC vs. TT: OR = 1.17, 95%CI = 0.96-1.24, P = 0.11%; CC vs. TT: OR = 0.90, 95%CI = 0.60-1.37, P = 0.63; TC+CC vs. TT: OR = 1.11, 95%CI = 0.90-1.38, P = 0.33; CC vs. TT+TC: OR = 0.92, 95%CI = 0.65-1.30, P = 0.63). Furthermore, similar associations were found in the subgroup analysis of race diversity, control design, genotyping methods, and different cancer types. In summary, our meta-analysis indicated that the SET8 rs16917496 T/C polymorphism may not play a critical role in cancer development in Asian populations.

[The comparison of the vasoactive effects of dopamine on isolated rabbit pulmonary and systemic arteries after incubation with lipopolysaccharide].

OBJECTIVE: To compare the vasoactive effects of dopamine (DOPA) of different concentrations on isolated rabbit pulmonary and systemic arteries after incubation with lipopolysaccharide (LPS). METHODS: Six white male rabbits were used. Thirty-six pulmonary arterial rings and 36 systemic arterial rings were prepared. The 36 pulmonary arterial rings were divided into six groups to determine the effect of different concentrations of DOPA (4x10(-5) , 8x10(-5), 16x10(-5) micromol/L) on the tension of the normal pulmonary artery (PN-DOPA4, PN-DOPA8, PN-DOPA16 groups, respectively), and the tension of the pulmonary artery rings after being incubated with LPS (PL-DOPA4, PL-DOPA8, PL-DOPA16 groups, respectively). The 36 systemic arterial rings were also divided into six groups as the pulmonary arterial rings, including normal groups (SN-DOPA4, SN-DOPA8 , SN-DOPA16) and LPS groups (SL-DOPA4, SL-DOPA8 , SL-DOPA16). RESULTS: (1) DOPA relaxed the arterial rings in PN-DOPA4 and SN-DOPA4 groups, while it produced contraction in PN-DOPA8, PN-DOPA16, SN-DOPA8 and SN-DOPA16 groups, and the contraction was more marked with the increase in concentration of DOPA. (2) After preincubation with LPS, the relaxation property of DOPA in PL-DOPA4 and SL-DOPA4 groups was observed to be reversed to contraction [(22.60+/-6.68)% vs. -(2.25+/-0.58)%, (3.80+/-0.52)% vs. -(3.65+/-0.75)%, P<0.05 and P<0.01]; the contraction response of DOPA in PL-DOPA8 group decreased compared with PN-DOPA8 group by (14.52+/-0.59)% (P<0.05), while increased by (25.90+/-1.75)% in SL-DOPA8 group compared with SN-DOPA8 group (P<0.05), and no response was observed in PL-DOPA16 and SL-DOPA16 groups. (3)After preincubation with LPS, changes in pulmonary arterial tension (PL/PN) in DOPA4 group were more obvious than those in systemic arterial tension (SL/SN, -10.90+/-5.06 vs. -1.00+/-0.24, P<0.05), while the SL/SN in DOPA8 group were more obvious (1.80+/-0.35 vs. 0.48+/-0.17, P<0.01). CONCLUSION: DOPA in low concentrations had the function of relaxation on the pulmonary arterial and systemic arterial rings. After the arterial rings are preincubated with LPS, the relaxation response of DOPA of low concentrations is changed to be vaso-contraction, and the changes in pulmonary arterial rings are most marked. DOPA of different concentrations all produce contraction effect on LPS-preincubated arterial rings.