Cleaving DNA-model phosphodiester with Lewis acid-base catalytic sites in bifunctional Zr-MOFs.

Organophosphates exist in many biomolecules. The design of artificial nucleases for efficient P-O bond cleavage is essential for the fields of genetic engineering and molecular biology. Herein, metal-organic frameworks (MOFs) with cooperatively isolated multi-catalytic active sites were utilized as heterogeneous catalysts for the hydrolytic cleavage of bis(p-nitrophenyl) phosphate (BNPP).