RESUMO
A series of new oxime and oxime ethers compounds were designed and virtually screened with target using the Molecular Operating Environmentï¼MOEï¼ software. Twelve unreported compounds including 4 oximes and 8 oxime ethers were synthesized with benzene, toluene, methoxybenzene and chlorobenzene as initial raw materials. Structures of compounds were elucidated by 1H NMR, 13C NMR and MS. The results of bioactive screening showed that a part of compounds displayed obviously anti-HBV activities. Inhibitory activities of compounds 4B-2 in secretion of HBsAg and HBeAg were IC50 HBsAg= 81.15 µmol·L-1, SIHBsAg = 9.20 and IC50 HBeAg = 90.66 µmol·L-1, SIHBeAg = 8.24, respectively. Preliminary structure-activity relationship study shows that methyl oxime ethers displayed better anti-HBV activities than the oximes.
Assuntos
Antivirais/química , Desenho de Fármacos , Vírus da Hepatite B/efeitos dos fármacos , Oximas/química , Éteres/química , Antígenos de Superfície da Hepatite B/metabolismo , Antígenos E da Hepatite B/metabolismo , Relação Estrutura-AtividadeRESUMO
The title compound, (C(11)H(14)N(4)O(4))[SbCl(4)]·H(2)O, comprises a protonated doxofyllinium cation [7-(1,3-dioxolan-2-ylmeth-yl)-1,3-dimethyl-2,6-dioxo-3,7-dihydro-1H-purin-9-ium], an [SbCl(4)](-) anion and a water mol-ecule linked by N-Hâ¯O and O-Hâ¯Cl hydrogen bonds: the [SbCl(4)](-) anions form centrosymmetric dimers via weak Sbâ¯Cl inter-actions [Sbâ¯Cl = 3.1159â (9)â Å]. The geometrical arrangement in the crystal structure is characterized by slipped π-π stacking of the parallel purine ring systems, with an inter-planar separation of 3.32â Å.