RESUMO
The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of HLA genes) contains polymorphic loci influencing the risk of developing non-Hodgkin's lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin's malignant lymphomas in the population of Western Siberia. Allele and genotype frequencies were determined in the group of 298 patients and in the control group including 551 individuals. Subgroups of diffuse large B-cell lymphoma (86 patients) and follicular lymphoma (25 patients) were analyzed separately. An association of rs2647012 Ð/Ð genotype with increased risk of the disease (OR = 2.78, p = 0.002) was detected in the subgroup of diffuse large B-cell lymphoma.
Assuntos
Estudo de Associação Genômica Ampla/métodos , Linfoma não Hodgkin/genética , Adulto , Idoso , Alelos , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético/genética , SibériaRESUMO
Allelic variants of folate cycle enzyme genes can contribute to predisposition to cancer. The impact of polymorphic loci A2756G of MTR gene and of C1420T of SHMT1 gene for the risk of prostatic cancer was studied in residents of West Siberia. The frequency of alleles of these loci in patients (N=371) and controls (N=285) was determined and the data were statistically processed. No statistically significant association with prostatic cancer was detected for any of the studied loci.
Assuntos
5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase/genética , Glicina Hidroximetiltransferase/genética , Polimorfismo de Nucleotídeo Único , Neoplasias da Próstata/genética , População Branca/genética , Adulto , Idoso , Alelos , Estudos de Casos e Controles , Ácido Fólico/metabolismo , Frequência do Gene , Loci Gênicos , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , SibériaAssuntos
Doença de Alzheimer/terapia , Instituições de Cuidados Especializados de Enfermagem/organização & administração , Idoso , Coleta de Dados , Ambiente de Instituições de Saúde , Humanos , Atividades de Lazer , Modelos Teóricos , Admissão e Escalonamento de Pessoal/estatística & dados numéricos , Estados UnidosRESUMO
The Service Workers Action Team (SWAT) is a three-year, community-based demonstration project for the elderly, with the primary goal of improving or maintaining psychosocial and physical functioning. With baseline scores and selected demography data os covariates, 243 experimental SWAT recipients were compared (MANOVA) with 158 controls after six months, with respect to: 1) Hopkin's Symptom Checklist, 2) Social Participation Scale, 3) Life Satisfaction Scale, 4) Self-Esteem Scale, 5) Activities of Daily Living, and 6) four selected health-related questions. The frequency of responses for the experimental elderly were computed for program satisfaction at the time of follow-up. In terms of psychosocial functioning, the experimental group fared significantly better at six months than did the control group. In terms of health, both groups declined in functional status, as evidenced by their scores on Activities of Daily Living, though the experimental subjects still were significantly better than the controls. The majority of the experimental group found the program to be helpful, with suggestions made for program expansion.
Assuntos
Serviços de Saúde Comunitária , Serviços de Saúde para Idosos , Idoso , Serviços de Saúde Comunitária/organização & administração , Comportamento do Consumidor , Coleta de Dados , Estudos de Avaliação como Assunto , Feminino , Florida , Serviços de Saúde para Idosos/organização & administração , Humanos , Pessoa de Meia-IdadeRESUMO
A backward-masking procedure was used to measure the rate of visual information processing in 8- and 10-year-old reflective and impulsive children. The test stimulus (TS) and the masking stimulus (MS) which followed it were presented tachistoscopially. The subject's information-processing threshold was defined as the next highest TS-MS interval above the interval where at least 3 of the 4 TSs were incorrectly identified. Reflective children were significantly faster than impulsive children at processing information. This finding was related to research indicating that reflective and impulsive children employ similar cognitive strategies; it was suggested that performance differences between these children might be related to reflective children employing their strategies with more adequate information.
