Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats.

Isoxicam at 25 mg/kg/day x 28 days significantly inhibited the multiple alterations with the developing polyarthritis. In rats, this drug did not induce any changes in the relative liver weights or serum SGPT, AP, or BUN in polyarthritic rats. Isoxicam absorption was similar in normal and arthritic rats.

Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.

Unlike several arylacetic acid derivatives (indomethacin, fenoprofen, ibuprofen, flurbiprofen and naproxen), the anti-arthritic activity of isoxicam is not reduced in the adjuvant-induced polyarthritis assay by the concomitant administration of aspirin or D-propoxyphene.

The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).

Isoxicam is a potent, orally active, nonsteroidal anti-inflammarory drug with prolonged activtiy in experimentally induced inflammation in rats. Isoxicam is less ulcerogenic, acutely less toxic and, therefore, appears to have a therapeutic ratio superior to other standard agents to which it was compared.

Effect of single and multiple treatments with phenylbutazone in normal and adjuvant-induced polyarthritic rats.

Liver function alterations, in the adjuvant induced polyarthritis procedure in rats, has been demonstrated by many investigators. We observed a significant inhibition of the polyarthritis with phenylbutazone but we were unable to find any changes in the relative liver weights of SGPT, AP or BUN in polyarthritic or phenylbutazone treated rats. However, we did observe that polyarthritic rats maintained a significantly higher plasma phenylbutazone concentration than the corresponding non-arthritic controls. This appears to futher substantiate the influence of 'pathopharmacodynamics' on the disposition and activity of drugs.

Comparison of the prolonged estrogenic and anti-fertility properties of quinestrol and four analogues.

PIP: A study was undertaken to compare the prolonged estrogenicity and antifertility properties of quinestrol and 4 analogues in rats. The following assays were used: 1) vaginal cornification; 2) uterine growth;and 3) timed pregnant rats. The last assay involved the administration of test compounds to pregnant rats at various times after mating and subsequent observation, on Day 19 after mating, of the number of continuing pregnancies, the weights of the uteri containing fetuses and placentas, and the number of fetuses or implantation sites. All of the quinestrol analogues had prolonged estrogenic activity as shown by the assays used, but quinestrol had the most protracted duration of activity. No correlation was seen between the chemical structure of the compounds and activity in the 3 assays.^ieng