Trends in postgraduate year 2 pharmacy residencies.

PURPOSE: The purpose of this study was to quantify the growth and trends in postgraduate year 2 (PGY2) pharmacy residencies. METHODS: Summaries of the American Society of Health-System Pharmacists (ASHP) Resident Matching Program from 2008 to 2021 were obtained. Only standalone PGY2 residencies were included in the analysis. Descriptive analyses were completed for data related to the programs and positions. RESULTS: From 2008 to 2021, the total number of ASHP-accredited PGY2 programs increased from 282 to 1,131 (301%) and the overall number of unfilled positions decreased from 22% (77 of 351) to 2% (34 of 1,492). The percentage of positions filled early increased from 23% (81 of 351) to 40% (594 of 1,492) during this time. In 2021, programs with a clinical focus accounted for 91.6% of total positions. The Ambulatory Care category accounted for the largest percentage of all PGY2 residency positions, at 19.2% (287 of 1,492) in 2021 compared to 12.8% (45 of 351) in 2008. The total share of PGY2 residency positions in the Critical Care category decreased from 22.8% (80 of 351) in 2008 to 13.7% (205 of 1,492) in 2021; however, the share of PGY2 residency positions in the Emergency Medicine category increased from 1.4% (5 of 351) to 5.9% (88 of 1,492). CONCLUSION: From 2008 to 2021 the total number of PGY2 residencies increased; however, this growth was uneven, as the share of positions within individual residency categories changed. It is important for pharmacy stakeholders to review the current state of postgraduate training and ensure it reflects the goals for future practice.

Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus.

Lactocrine communication of milk-borne bioactive factors (MbFs) from mother to offspring through nursing can affect neonatal development with lasting consequences. Relaxin (RLX), a lactocrine-active peptide found in porcine colostrum, stimulates estrogen receptor-α (ESR1) expression required for uterine development shortly after birth (postnatal day=PND 0). Whether other MbFs or cooperative lactocrine mechanisms affect the neonatal uterine developmental program is unknown. To determine the effects of age, nursing, and exogenous RLX on gene expression associated with uterine development, gilts (n=4-5/group) were assigned to nurse ad libitum or to receive milk replacer, with or without exogenous RLX (20 µg/kg BW i.m./6 h for 48 h), from birth to PND 2 when uteri were collected. Body weight and uterine weight increased (P<0.05) similarly from birth to PND 2 in all gilts. However, colostrum consumption was required for normal uterine ESR1, vascular endothelial growth factor (VEGFA), matrix metalloproteinase 9 (MMP9), and RLX receptor (RXFP1) protein and/or transcript expression on PND 2. Uterine ESR1, VEGFA, and MMP9 protein levels were below (P<0.01) the assay sensitivity in replacer-fed gilts. Supplemental RLX increased (P<0.05) uterine ESR1 protein and mRNA in nursed gilts, as well as VEGFA protein in nursed and VEGFA mRNA in both nursed and replacer-fed gilts. RLX treatment did not affect uterine MMP9 mRNA levels. When compared with replacer-fed gilts on PND 2, uterine RXFP1 mRNA was reduced (P<0.05) in nursed gilts and in RLX-supplemented replacer-fed gilts. These results constitute the first evidence that establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support.