RESUMO
As the nation's health system moves away from earlier models to one grounded in population health and market-based systems of care, new challenges arise for public health professionals, primary care practitioners, health plan and institutional managers, and community leaders. Among the challenges are the need to develop creative concepts of organization and accountability and to assure that dynamic, system-oriented structures support the new kind of leadership that is required. Developing tomorrow's integrated community health systems will challenge the leadership skills and integrative abilities of public health professionals, primary care practitioners, and managers. These leaders and their new organizations must, in turn, assume increased accountability for improving community health.
Assuntos
Serviços de Saúde Comunitária/organização & administração , Prestação Integrada de Cuidados de Saúde/organização & administração , Liderança , Atenção Primária à Saúde/organização & administração , Administração em Saúde Pública , Previsões , Humanos , Marketing de Serviços de Saúde , Modelos Organizacionais , Competência Profissional , Garantia da Qualidade dos Cuidados de Saúde , Estados UnidosRESUMO
Many cases reported as malignant melanomas arising in benign congenital melanocytic nevi in the neonatal period have not shown evidence of metastases after several years of follow-up. These lesions were probably pathologically misdiagnosed, thus creating a controversy regarding the precise incidence. This article describes the case of an infant with a giant melanocytic nevus simulating malignant melanoma to illustrate the proper criteria for diagnosis of this condition so extensive and unnecessary therapy procedures can be avoided.
Assuntos
Melanoma/diagnóstico , Nevo Pigmentado/congênito , Nevo Pigmentado/diagnóstico , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/diagnóstico , Diagnóstico Diferencial , Humanos , Lactente , Masculino , Melanoma/patologia , Nevo Pigmentado/patologia , Nevo Pigmentado/cirurgia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
Mohs micrographic surgery has been highly successful in treating skin cancers that grow in a contiguous manner. The technique requires removal of involved tissue in thin layers and histographic mapping to pinpoint residual tumor. This process is repeated until all of the tumor is resected. This allows 100 percent of all margins to be examined and is very tissue conservative, attributing to its unsurpassed cure rates and excellent cosmetic results. Since it is done as an outpatient procedure under local anesthetic, it also is safe and efficient.
Assuntos
Carcinoma Basocelular/cirurgia , Cirurgia de Mohs , Neoplasias Cutâneas/cirurgia , História do Século XX , Humanos , Masculino , Pessoa de Meia-Idade , Cirurgia de Mohs/históriaRESUMO
The concept of a mononuclear phagocytic system consisting of a continuum of cells arising from the bone marrow monoblast and terminating in the mature tissue macrophage is being actively investigated. The presentation of documented acute monocytic leukemia 18 months following the confirmed diagnosis of histiocytosis X in a 39-year-old man strongly supports the concept of the mononuclear phagocytic system lineage.
Assuntos
Histiocitose de Células de Langerhans/patologia , Leucemia Monocítica Aguda/patologia , Monócitos/patologia , Dermatopatias/patologia , Adulto , Diferenciação Celular , Histiocitose de Células de Langerhans/complicações , Humanos , Leucemia Monocítica Aguda/complicações , Masculino , Monócitos/citologia , Fagocitose , Dermatopatias/complicações , Fatores de TempoRESUMO
Four patients with psoriasis were treated with continuous ambulatory peritoneal dialysis (CAPD). Two were being treated for renal failure; the other two had normal renal function and were being treated exclusively for psoriasis. With CAPD at a rate of three to four exchanges per day, the psoriasis cleared completely in the two patients with renal failure and improved in the other two. In the patients without renal failure, low-flow peritoneal dialysis (one exchange per day) seemed to be of some value in maintaining remission but was ineffective in treating more active disease. Long-term therapy (greater than or equal to 12 weeks) with three or four daily exchanges may be needed for initial complete remission, and continuous treatment may be needed to prevent relapse. Thus, CAPD shows promise for the study of psoriasis and may be a last-resort treatment for severe, disabling cases.
Assuntos
Diálise Peritoneal Ambulatorial Contínua , Psoríase/terapia , Adulto , Doença Crônica , Estudos de Avaliação como Assunto , Feminino , Glomerulonefrite/terapia , Glomerulosclerose Segmentar e Focal/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Diálise Peritoneal Ambulatorial Contínua/métodos , Psoríase/complicações , Psoríase/patologia , Pele/patologia , Fatores de TempoRESUMO
A scabies epidemic was studied in a university hospital dialysis unit. Itching in patients was initially attributed to uremic pruritus, and diagnosis of the epidemic was delayed until cases occurred among the staff. Sixteen cases (seven patients and nine staff) were identified by survey questionnaire and dermatologic examination. Application of 1% lindane lotion (Kwell, Reed and Carnrick, Piscataway, NJ) to all patients dialyzed in the unit and the entire staff eradicated the epidemic. A dialysis unit-associated nosocomial scabies epidemic has not been reported before and may mimic uremic pruritus in dialysis patients.
Assuntos
Surtos de Doenças/epidemiologia , Unidades Hospitalares de Hemodiálise , Unidades Hospitalares , Prurido/etiologia , Escabiose/epidemiologia , Dermatopatias Parasitárias/epidemiologia , Antiparasitários , Infecção Hospitalar/diagnóstico , Infecção Hospitalar/epidemiologia , Diagnóstico Diferencial , Hexaclorocicloexano/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Prurido/diagnóstico , Escabiose/diagnóstico , Escabiose/tratamento farmacológico , Dermatopatias Parasitárias/diagnóstico , Uremia/complicações , West VirginiaRESUMO
A study of tinea versicolor organisms was conducted in one patient by scanning electron microscopy. Morphologic changes in the organisms during treatment with topical clotrimazole and miconazole nitrate consisted of initial wrinkling of the surface, followed by fragmentation. These changes may have reflected cell wall alterations resulting from inhibited ergosterol synthesis induced by both treatment agents. The two drugs were effective in eliminating the organisms.
Assuntos
Malassezia/ultraestrutura , Pele/ultraestrutura , Tinha Versicolor/patologia , Administração Tópica , Adulto , Clotrimazol/uso terapêutico , Humanos , Masculino , Miconazol/uso terapêutico , Microscopia Eletrônica de Varredura , Pele/microbiologia , Tinha Versicolor/tratamento farmacológico , Tinha Versicolor/microbiologiaRESUMO
The study sought to establish baselines for personality and frequency of psychopathology in familial dysautonomia (FD). Fifty FD patients, aged 6 to 28 years, served as subjects. FD subjects in all age ranges manifest neurotic patterns, but show no greater incidence of more severe pathology than is found in the general population. the arrested psychologic development seen in FD is described, together with the phenomenon of periodic lapses in judgment. The organic impairment of cognitive functions is discussed. Recommendations for treatment are proposed.
Assuntos
Disautonomia Familiar/psicologia , Desenvolvimento da Personalidade , Adolescente , Adulto , Questionário de Fatores de Personalidade de Cattell , Criança , Humanos , Psicologia do Adolescente , Teste de RorschachRESUMO
The study examined adaptive trends in cognitive development among individuals with familial dysautonomia and sought to establish new base rates of intelligence for the dysautonomic population. Fifty-two subjects, aged 6 to 28 years, were administered the Wechsler scales of intelligence. The results indicate that there is less cognitive impairment than previous research would suggest, and that more dysautonomic children are capable of adjusting to standard school programs than was heretofore thought possible. Specific deficits seen in this population are discussed along with a rationale for deleting the term retarded where most of these individuals are concerned.
Assuntos
Disautonomia Familiar/psicologia , Inteligência , Adolescente , Adulto , Criança , Disautonomia Familiar/complicações , Humanos , Deficiência Intelectual/etiologia , Escalas de WechslerAssuntos
Sarcoidose , Feminino , Humanos , Pessoa de Meia-Idade , Sarcoidose/diagnóstico , Sarcoidose/imunologia , Sarcoidose/patologiaRESUMO
Lymphangioma circumscriptum is a rare disorder that is localized to the skin. To our knowledge, involvement of deeper lymphatic structures has been reported on only two prior occasions. Our patient had typical lymphangioma circumscriptum of her inner thigh, which was associated with deep lymphatic involvement and enlargement of the extremity. We report this case to alert others to this disease entity.
Assuntos
Linfangioma/diagnóstico , Doenças Linfáticas/diagnóstico , Coxa da Perna , Adolescente , Feminino , Humanos , Linfangioma/patologia , Doenças Linfáticas/patologia , Coxa da Perna/patologiaRESUMO
We report a case of squamous cell carcinoma of the lung associated with the sudden appearance of seborrheic keratosis and acquired ichthyosis. We conclude that the sign of Leser-Trélat is a rare cutaneous manifestation of internal malignant disease.
Assuntos
Carcinoma de Células Escamosas/complicações , Ictiose/complicações , Ceratose/complicações , Neoplasias Pulmonares/complicações , Manifestações Cutâneas , Fatores Etários , Idoso , Dermatite Seborreica/complicações , Humanos , MasculinoRESUMO
Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produce the clinical features of primarily distal weakness and wasting. Recovery appears to occur via axon regeneration and peripheral sprouting. The sporadic occurrence of this neuropathy may be due to slow acetylation of dapsone in some patients.