1.
Mar Drugs
; 16(12)2018 Nov 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30477129
RESUMO
Three new thiodiketopiperazines, geospallins Aâ»C (1â»3), together with nine known analogues (4â»12), were isolated from the culture of the deep-sea sediment-derived fungus Geosmithia pallida FS140. Among them, geospallins A and B (1 and 2) represent rare examples of thiodiketopiperazines featuring an S-methyl group at C-10 and a tertiary hydroxyl group at C-11. Their structures were determined by high-resolution electrospray mass spectrometry (HRESIMS), spectroscopic analyses, and electronic circular dichroism (ECD) calculations. Their angiotensin-converting enzyme (ACE) inhibitory activity was reported, and geospallins Aâ»C (1â»3) showed inhibitory activity with IC50 values of 29â»35 µM.