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Future Oncol ; 19(35): 2361-2367, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37965794

RESUMO

Aim: Clinical utility of the dynamics of ctDNA is sparse. This study aimed at evaluating the prognostic impact of early ctDNA dynamics in patients with metastatic cancer treated with chemotherapy. Materials & methods: The ctDNA dynamics were evaluated in 595 patients with metastatic cancer using droplet digital PCR. Results: Patients with an increase in ctDNA after one treatment cycle (n = 73; 12.2%) had an overall survival of 5.6 months compared with 8.6 months in patients with stable or decreasing ctDNA (n = 328; 55.1%) and 21.0 months in patients with undetectable ctDNA (p < 0.001; hazard ratio: 0.47; 95% CI: 0.41-0.53). Conclusion: Early ctDNA dynamics hold important prognostic information and have great implications for evaluation with the perspective of a more individualized treatment strategy.


Assuntos
DNA Tumoral Circulante , Segunda Neoplasia Primária , Humanos , Prognóstico , DNA Tumoral Circulante/genética , Modelos de Riscos Proporcionais , Biomarcadores Tumorais/genética
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