Construction of intelligent fall warning model for the elderly based on plantar pressure / 中国实用护理杂志

Objective:To realize the accurate prediction of the fall risk of the elderly by a convolutional neural network prediction model.Methods:Stratified random cluster sampling was used from June 2019 to February 2020, Python′s Matlabplot library and Opencv library were used to perform data preprocessing on the plantar pressure data of 1 093 subjects who had come from medical institutionsand community or elderly care institutions of Chongqing and Nanjing, such as data visualization, compression and clipping, grayscale, Gaussian blur, etc., and then the data were divided into training set (983 cases) and verification set (110 cases), the training set data were used to train the convolutional neural network model, the verification set was used to verify the model, and the ReLU function was used to suppress overfitting to obtain the final prediction model.Results:The sensitivity of the fall warning model to the validation set for predicting falls was 91.2%, the specificity was 81.4%, the accuracy was 91.5%, and the AUC was 0.865.Conclusions:The fall prediction model can predict the fall risk of the elderly in a specific scenario. In the subsequent improvement, the software and hardware construction should be comprehensively improved to further improve the prediction accuracy.

Investigation on Properties of Collagen Nanowires Quasiepitaxially Grown on Mica Lattice Plane / 分析化学

Collagen fibrils and hydroxyapatite might recognize each other at the mesoscale by multiple cooperative interactions due to their intrinsically repetitive structured surfaces, and thus effectively directing the biomineralization, a biological process involving regulating the growth of bones, teeth and other organs. In this work, we developed a simple technique to prepare nanowire arrays of biological macromolecules by reversely using the biomineralization mechanism, with results similar to the hot wall epitaxy, a molecular beam deposition technique under vacuum. With this technique, we successfully cultured 5-10 μg/mL rat tail type I collagen monomer solutions into collagen nanowire arrays on the mica (001) lattice plane along one unique direction across the whole cleavage surface. The atomic force microscope experiments indicated that the nanowires in the arrays became more crowded with higher monomer concentration, but their width and height remained unchanged, about 60.0 nm and 1.5 nm, respectively. The collagen nanowire coating enhanced the hydrophilicity of the mica surface, reducing the contact angle from 25.8° to 9.5°. Based on the characterization results of electron back scattering diffraction and transmission electron microscope, the collagen nanowires were most likely to be oriented along the mica [110] direction, which validated the quasiepitaxial growth mechanism in more details.

The incidence and types of acid-base disorder of critically ill patients in emergency / 中华急诊医学杂志

Objective To reveal the incidence and types of acid-base disorder (ABD) of critically ill patients in emergency.Methods The clinical data of critically ill patients in the resuscitation room were collected prospectively from December 1,2008 to March 31,2009.Both arterial and venous blood samples were collected to detect arterial blood gas analysis and serum electrolytes simultaneously and their ABD were analyzed.Results Of totally 766 cases,the incidence of ABD was 97.3％ (745 cases).Among ABD the simple acid-base disorder ( SA BD) was 149 cases ( 20.0％ ),dual acid-base disorder (DABD) 525 (70.5％ ) and triple acid-base disorder (TABD) 71 (9.5％ ).After calculating anion gap (AG),the incidence of TABD increased from 12 to 71 cases and the missed diagnosis rate were 83.1％ (59 cases) and after calculating potential HCO3-,the incidence of TABD increased from 8 to 71 cases and the missed diagnosis rate were 88.7％ (63 cases).The age of patients with TABD (77.9 ± 10.7 years old) was older ( P ＜ 0.01 ) than that of other two groups of SABD and DABD as well as APACHEⅡ score (25.9 ± 7.1 ) and incidence (22.5％ ) of MODS in TABD were higher (P ＜0.01 ).The mortality of patients with TABD on the first,second,third and seven day were 14.1％,23.9％,26.8％ and 38.0％ respectively and significantly higher than those in SABD and DABD (P ＜0.05 or P ＜0.01 ).Conclusions The incidence of ABD was 97.3％.Calculation of AG and potential HCO3- would help find metabolic acidosis and TABD.The age and APACHEⅡ score were key factors to poor prognosis of patients with TABD.

Evaluation of the effects of radiofrequency hyperthermia combined with chemotherapy in treating advanced or metastatic gastrointestinal cancer / 中国实用内科杂志

Objective To observe the acute effects and symptom relief of radiofrequency hyperthermia combined with chemotherapy in treating advanced or metastatic gastrointestinal cancer.Methods 50 cases with advanced or metatatic gastrointestinal cancer that recurrent after operation or can not be resected were all treated by local radiofrequency hyper- thermia combined with chemotherapy.In every cycle of chemotherapy,radiofrequency hyperthermia was given 2 to 3 times,60 minutes per time.One case complete chemotherapy 3 to 6 cycles and the total times of radiofrequency hyper- thermia ranged from 6 to 16.Results In 50 cases,the rate of effects was 38% and the rate of symptom relief was 46%.Conclusion In the combined therapy for advanced or metastatic gastrointestinal cancer,the radiofrequency hy- perthermia has some value in relieving symptoms,improving living quality and controlling tumour.

Consideration to the Promotion of Education and Research of Social Pharmacy / 中国药房

OBJECTIVE:To promote the education and research of social pharmacy in China METHODS:This article introduces the definition of social pharmacy,the history and current situation in foreign countries,and to analyse the history and development of pharmacy administration in China RESULTS & CONCLUSION:Some preliminary suggestions about the promotion of education and research of social pharmacy in China are put forward

Clinical and Radiological Analysis of Mamma Virilis Development / 实用放射学杂志

Objective To study the clinical and X-ray findings in mamma virilis devolopment.Methods Clinical and X-ray findings in 11 patients with primary mamma virilis development were presented and analysed retrospectvely.Results X-ray findings were divided into 3 groups:1)mass(n=4):round or oval mass with high density and well-defined border;2)patch(n=4):patch like uneven mass with high density and ill-defined border;3)nodule(n=3):irregular uneven nodules.Conclusion Clinical and X-ray findings of mamma virilis development have some characteristic features,it can be differentiated from mamary cancer and pseudogynecomastia.