Oral cancer reconstruction using the pedicled supraclavicular artery island flap: comparison to pectoralis major myocutaneous flap / 中华整形外科杂志

Objective@#To compare the pedicled supraclavicular artery island flap (SCAIF) and the pectoralis major myocutaneous flap (PMMF) for oral reconstruction after cancer resection.@*Methods@#This is a retrospective study from May 2007 to May 2017. Sixty-one patients from the Jiangxi University of Traditional Chinese Medicine and the First Affiliated Hospital of Nanchang University, were included. All the patients underwent oral squamous cell carcinoma resection and pedicled flap reconstruction. Sixteen patients were performed SCAIFs (group A), and 45 were performed PMMFs (group B). The flap survival rate, flap size, flap preparation time, the presence of scar hyperplasia, pigmentation and dysfunction (temporary or permanent) were compared between these two groups.@*Results@#The survival rate of flaps in group A was 93.75% (15/16), and the survival rate of flaps in group B was 95.56% (43/45). There was no statistically significant difference in the survival rate of flaps, the average skin flap size or flap produce time between these 2 groups. There were no scar hyperplasia, pigmentation and dysfunction was observed in group A. However, scar hyperplasia (n=11), pigmentation (n=10) and dysfunction (n=12) occurred in group B. The difference was statistically significant (P<0.05).@*Conclusions@#This study suggests that SCAIF is more reliable, and brings more satisfied outcome, when compared with the PMMF.

Alkaloids and lignans from stems of Piper betle / 中国中药杂志

Alkaloids and lignans from the stems of Piper betle were studied. Compounds were isolated and purified by repeated silica gel, reverse phase silica gel, Sephadex LH-20 column chromatography and preparative thin layer chromatography. The structures were elucidated on the basis of spectral analysis. From the ethyl acetate soluble fractions of the 70% acetone extract, ten compounds were isolated and identified as piperine (1), pellitorine (2), N-isobutyl-2E,4E-dodecadienamide (3), dehydropipernonaline (4), piperdardine (5), piperolein-B (6), guineensine (7), (2E,4E)-N-isobutyl-7-(3',4'-methylenedioxyphenyl)-2,4-heptadienamide (8), syringaresinol-O-beta-D-glucopyranoside (9),pinoresinol (10). All Compounds were isolated from the plant for the first time, and compounds 9 and 10 were isolated firstly from the genus.

Effect of 99Tc methylenediphosphonate injection on morning stiffness duration and tender swollen index of patients with rheumatoid arthritis / 中国组织工程研究

BACKGROUND: Among lots of drugs treating rheumatic arthritis, 99Tc methylenediphosphonate injection is a novel one whose anti-inflammation effect is enabled through electronic acquirement or deprivation of technetium.OBJECTIVE: To observe the effect of 99Tc methylenediphosphonate injection on rheumatic arthritis.DESIGN: Randomized controlled trial.SETTING: A Traditional Chinese Medicine Department of Xinqiao Hospital Affiliated to the Third Military Medical University of Chinese PLA.PARTICIPANTS: There were 85 patients diagnosed with rheumatoid arthritis and admitted to Xinqiao Hospital from March 2000 to December 2001. Sixty-six patients were enrolled in this trial for the manifestation of four or more of the following signs for 6 weeks: morning stiffness for at least one hour, more than 3 joints affected, symmetrical arthritis, positive rheumatoid nodules and serum rheumatoid factor, accelerated erythrocyte sedimentation and typical X-ray signs of rheumatic arthritis. Among the 66 patients, 23 were males and 43 were females with the age of 18-62 years old(mean 42.23 years) . The course varied from 2 months to 12 years. They were randomly assigned into treatment group and control group with 33 each.METHODS: The patients in the treatment group received 99Tc methylenediphosphonate injection injection and oral administration of placebo while those in the control group received placebo injection and oral administration of naproxen for 12 days. The morning stiffness duration, numbers of tender joints and swollen joints, erythrocyte sedimentation, C reactive protein, rheumatoid factor and total effective rate in the two groups were recorded and compared to assess the therapeutic effect.MAIN OUTCOME MEASURES: The morning stiffness duration, numbers of tender joints and swollen joints, erythrocyte sedimentation, C reactive protein and rheumatoid factor in the two groups and adverse effect of 99Tc met hylenediphosphonate injection.RESULTS: According to intention to deal with the analysis, none of the 66 duration and the reduction in the number of tender and swollen joints in the treatment group were better than those in the control group[ (70.39 ± 40. 32) minute, (3.27±2.21), (3.20±2.38) vs(35.82±24.65) minute,erythrocyte sedimentation, C reactive protein and rheumatoid factor in the two significantly higher than that(64% ) in control group(X2 = 4. 89, P ＜ 0.05).CONCLUSION: 99Tc methylenediphosphonate injection is better than naproxen in ameliorating articular swelling and tenderness as well as morning stiffness of rheumatic arthritis while the effect of 99Tc methylenediphosphonate injection on erythrocyte sedimentation, C reactive protein and rheumatoid factor was similar to that of naproxen.Huang WQ. Effect of 99Tc methylenediphosphonate injection on morning stiffness duration and tender swollen index of patients with rheumatoid arthritis.

Reestablishment of second hepatic hilum: a new technique for the treatment of Budd-Chiari syndrome / 中华医学杂志(英文版)

<p><b>OBJECTIVE</b>To assess a new intervention for reestablishing the second hepatic hilum by means of puncturing and stenting the liver tissue between the intrahepatic vena cava and a hepatic vein for the treatment of Budd-Chiari syndrome (BCS).</p><p><b>METHODS</b>Two patients with BCS, in which no second hepatic hilum structure was found in transhepatic venography, underwent an interventional procedure of canalizing and stenting the parenchyma tract between the intrahepatic vena cava and a hepatic vein. The procedures were performed in the percutaneous transhepatic and right jugular vein, respectively. A metallic stent with a 10 mm diameter was implanted to maintain tract patency.</p><p><b>RESULTS</b>The free hepatic vein pressure (FHVP) of both patients decreased from 37 mm Hg to 5 mm Hg and from 28 mm Hg to 4 mm Hg, respectively, after the procedure. The complication of hemorrhage due to puncture was observed in one patient. Both patients maintained hepatic improvements in 3-year follow-up. Both clinical conditions and laboratory values were significantly improved after the procedure. Furthermore, the stented canals (the reestablished second hepatic hilum) maintained patent with normal FHVP, which was confirmed by control venography.</p><p><b>CONCLUSION</b>The new technique provides a simple, safe, effective, and relatively inexpensive treatment of Budd-Chiari syndrome. Long-lasting effectiveness is expected.</p>